Search Results - "Vuckovic, Dragana"

Genetic variation in cervical preinvasive and invasive disease: a genome-wide association study by Bowden, Sarah J, Bodinier, Barbara, Kalliala, Ilkka, Zuber, Verena, Vuckovic, Dragana, Doulgeraki, Triada, Whitaker, Matthew D, Wielscher, Matthias, Cartwright, Rufus, Tsilidis, Konstantinos K, Bennett, Phillip, Jarvelin, Marjo-Riitta, Flanagan, James M, Chadeau-Hyam, Marc, Kyrgiou, Maria

“…Most uterine cervical high-risk human papillomavirus (HPV) infections are transient, with only a small fraction developing into cervical cancer. Family…”
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A bird's-eye view of Italian genomic variation through whole-genome sequencing by Cocca, Massimiliano, Barbieri, Caterina, Concas, Maria Pina, Robino, Antonietta, Brumat, Marco, Gandin, Ilaria, Trudu, Matteo, Sala, Cinzia Felicita, Vuckovic, Dragana, Girotto, Giorgia, Matullo, Giuseppe, Polasek, Ozren, Kolčić, Ivana, Gasparini, Paolo, Soranzo, Nicole, Toniolo, Daniela, Mezzavilla, Massimo

“…The genomic variation of the Italian peninsula populations is currently under characterised: the only Italian whole-genome reference is represented by the…”
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A genome-wide meta-analysis yields 46 new loci associating with biomarkers of iron homeostasis by Bell, Steven, Rigas, Andreas S., Magnusson, Magnus K., Ferkingstad, Egil, Allara, Elias, Bjornsdottir, Gyda, Ramond, Anna, Sørensen, Erik, Halldorsson, Gisli H., Paul, Dirk S., Burgdorf, Kristoffer S., Eggertsson, Hannes P., Howson, Joanna M. M., Thørner, Lise W., Kristmundsdottir, Snaedis, Astle, William J., Erikstrup, Christian, Sigurdsson, Jon K., Vuckovic, Dragana, Dinh, Khoa M., Tragante, Vinicius, Surendran, Praveen, Pedersen, Ole B., Vidarsson, Brynjar, Jiang, Tao, Paarup, Helene M., Onundarson, Pall T., Akbari, Parsa, Nielsen, Kaspar R., Lund, Sigrun H., Juliusson, Kristinn, Magnusson, Magnus I., Frigge, Michael L., Oddsson, Asmundur, Olafsson, Isleifur, Kaptoge, Stephen, Hjalgrim, Henrik, Runarsson, Gudmundur, Wood, Angela M., Jonsdottir, Ingileif, Hansen, Thomas F., Sigurdardottir, Olof, Stefansson, Hreinn, Rye, David, Peters, James E., Westergaard, David, Holm, Hilma, Soranzo, Nicole, Banasik, Karina, Thorleifsson, Gudmar, Ouwehand, Willem H., Thorsteinsdottir, Unnur, Roberts, David J., Sulem, Patrick, Butterworth, Adam S., Gudbjartsson, Daniel F., Danesh, John, Brunak, Søren, Di Angelantonio, Emanuele, Ullum, Henrik, Stefansson, Kari

“…Iron is essential for many biological functions and iron deficiency and overload have major health implications. We performed a meta-analysis of three…”
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Next-generation sequencing identified SPATC1L as a possible candidate gene for both early-onset and age-related hearing loss by Morgan, Anna, Vuckovic, Dragana, Krishnamoorthy, Navaneethakrishnan, Rubinato, Elisa, Ambrosetti, Umberto, Castorina, Pierangela, Franzè, Annamaria, Vozzi, Diego, La Bianca, Martina, Cappellani, Stefania, Di Stazio, Mariateresa, Gasparini, Paolo, Girotto, Giorgia

“…Hereditary hearing loss (HHL) and age-related hearing loss (ARHL) are two major sensory diseases affecting millions of people worldwide. Despite many efforts,…”
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Linkage study and exome sequencing identify a BDP1 mutation associated with hereditary hearing loss by Girotto, Giorgia, Abdulhadi, Khalid, Buniello, Annalisa, Vozzi, Diego, Licastro, Danilo, d'Eustacchio, Angela, Vuckovic, Dragana, Alkowari, Moza Khalifa, Steel, Karen P, Badii, Ramin, Gasparini, Paolo

“…Nonsyndromic Hereditary Hearing Loss is a common disorder accounting for at least 60% of prelingual deafness. GJB2 gene mutations, GJB6 deletion, and the…”
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Expression and replication studies to identify new candidate genes involved in normal hearing function by Girotto, Giorgia, Vuckovic, Dragana, Buniello, Annalisa, Lorente-Cánovas, Beatriz, Lewis, Morag, Gasparini, Paolo, Steel, Karen P

“…Considerable progress has been made in identifying deafness genes, but still little is known about the genetic basis of normal variation in hearing function…”
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Mutations in L-type amino acid transporter-2 support SLC7A8 as a novel gene involved in age-related hearing loss by Espino Guarch, Meritxell, Font-Llitjós, Mariona, Murillo-Cuesta, Silvia, Errasti-Murugarren, Ekaitz, Celaya, Adelaida M, Girotto, Giorgia, Vuckovic, Dragana, Mezzavilla, Massimo, Vilches, Clara, Bodoy, Susanna, Sahún, Ignasi, González, Laura, Prat, Esther, Zorzano, Antonio, Dierssen, Mara, Varela-Nieto, Isabel, Gasparini, Paolo, Palacín, Manuel, Nunes, Virginia

“…Age-related hearing loss (ARHL) is the most common sensory deficit in the elderly. The disease has a multifactorial etiology with both environmental and…”
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Biological age estimation using circulating blood biomarkers by Bortz, Jordan, Guariglia, Andrea, Klaric, Lucija, Tang, David, Ward, Peter, Geer, Michael, Chadeau-Hyam, Marc, Vuckovic, Dragana, Joshi, Peter K.

“…Biological age captures physiological deterioration better than chronological age and is amenable to interventions. Blood-based biomarkers have been identified…”
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Machine learning optimized polygenic scores for blood cell traits identify sex-specific trajectories and genetic correlations with disease by Xu, Yu, Vuckovic, Dragana, Ritchie, Scott C., Akbari, Parsa, Jiang, Tao, Grealey, Jason, Butterworth, Adam S., Ouwehand, Willem H., Roberts, David J., Di Angelantonio, Emanuele, Danesh, John, Soranzo, Nicole, Inouye, Michael

“…Genetic association studies for blood cell traits, which are key indicators of health and immune function, have identified several hundred associations and…”
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Automated calibration of consensus weighted distance-based clustering approaches using sharp by Bodinier, Barbara, Vuckovic, Dragana, Rodrigues, Sabrina, Filippi, Sarah, Chiquet, Julien, Chadeau-Hyam, Marc

“…Abstract Motivation In consensus clustering, a clustering algorithm is used in combination with a subsampling procedure to detect stable clusters. Previous…”
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Advances in understanding the pathogenesis of hereditary macrothrombocytopenia by Collins, Janine, Astle, William J., Megy, Karyn, Mumford, Andrew D., Vuckovic, Dragana

“…Summary Low platelet count, or thrombocytopenia, is a common haematological abnormality, with a wide differential diagnosis, which may represent a clinically…”
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Machine Learning for Identification of High-Risk Clonal Haematopoiesis Using Blood Count Data by Dunn, William G, Withnell, Isabella, Gu, Muxin, Quiros, Pedro, Cheloor Kovilakam, Sruthi, Marando, Ludovica, Fabre, Margarete, Mohorianu, Irina, Vuckovic, Dragana, Vassiliou, George

“…Introduction: Clonal haematopoiesis (CH) is a common, age-related phenomenon associated with an increased risk of myeloid malignancies (MM), raising the…”
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Polygenic Germline Risk of Common Haematological Traits Drives Clonal Selection on JAK2 V617F and Development of Myeloproliferative Neoplasms by Nangalia, Jyoti, Guo, Jing, Walter, Klaudia, Quiros, Pedro, Gu, Muxin, Baxter, E Joanna, Danesh, John, Di Angelantonio, Emanuele, Roberts, David, Guglielmelli, Paola, Harrison, Claire N, Godfrey, Anna L, Green, Anthony R, Vassiliou, George, Vuckovic, Dragana, Soranzo, Nicole

“…Polygenic germline loci are a major contributor to population variation in common blood cell traits, but little is known about how such predisposition…”
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Educational patterning in biological health seven years apart: Findings from the Tromsø Study by Neufcourt, Lola, Castagné, Raphaële, Wilsgaard, Tom, Grimsgaard, Sameline, Chadeau-Hyam, Marc, Vuckovic, Dragana, Ugarteche-Perez, Ainhoa, Farbu, Erlend Hoftun, Sandanger, Torkjel M, Delpierre, Cyrille, Kelly-Irving, Michelle

“…Social-to-biological processes is one set of mechanisms underlying the relationship between social position and health. However, very few studies have focused…”
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Association of hair polychlorinated biphenyls and multiclass pesticides with obesity, diabetes, hypertension and dyslipidemia in NESCAV study by Peng, Feng-Jiao, Lin, Chia-An, Wada, Rin, Bodinier, Barbara, Iglesias-González, Alba, Palazzi, Paul, Streel, Sylvie, Guillaume, Michèle, Vuckovic, Dragana, Chadeau-Hyam, Marc, Appenzeller, Brice M.R.

“…Obesity, diabetes, hypertension and dyslipidemia are well-established risk factors for cardiovascular diseases (CVDs), and have been associated with exposure…”
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Inherited polygenic effects on common hematological traits influence clonal selection on JAK2V617F and the development of myeloproliferative neoplasms by Guo, Jing, Walter, Klaudia, Quiros, Pedro M., Gu, Muxin, Baxter, E. Joanna, Danesh, John, Di Angelantonio, Emanuele, Roberts, David, Guglielmelli, Paola, Harrison, Claire N., Godfrey, Anna L., Green, Anthony R., Vassiliou, George S., Vuckovic, Dragana, Nangalia, Jyoti, Soranzo, Nicole

“…Myeloproliferative neoplasms (MPNs) are chronic cancers characterized by overproduction of mature blood cells. Their causative somatic mutations, for example,…”
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Hair-Derived Exposome Exploration of Cardiometabolic Health: Piloting a Bayesian Multitrait Variable Selection Approach by Wada, Rin, Peng, Feng-Jiao, Lin, Chia-An, Vermeulen, Roel, Iglesias-González, Alba, Palazzi, Paul, Bodinier, Barbara, Streel, Sylvie, Guillaume, Michèle, Vuckovic, Dragana, Dagnino, Sonia, Chiquet, Julien, Appenzeller, Brice M. R., Chadeau-Hyam, Marc

“…Cardiometabolic health is complex and characterized by an ensemble of correlated and/or co-occurring conditions including obesity, dyslipidemia, hypertension,…”
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Transcriptome-wide association study in UK Biobank Europeans identifies associations with blood cell traits by Rowland, Bryce, Venkatesh, Sanan, Tardaguila, Manuel, Wen, Jia, Rosen, Jonathan D, Tapia, Amanda L, Sun, Quan, Graff, Mariaelisa, Vuckovic, Dragana, Lettre, Guillaume, Sankaran, Vijay G, Voloudakis, Georgios, Roussos, Panos, Huffman, Jennifer E, Reiner, Alexander P, Soranzo, Nicole, Raffield, Laura M, Li, Yun

“…Abstract Previous genome-wide association studies (GWAS) of hematological traits have identified over 10 000 distinct trait-specific risk loci. However, at…”
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Genome-wide association meta-analysis of individuals of European ancestry identifies new loci explaining a substantial fraction of hair color variation and heritability by Hysi, Pirro G., Valdes, Ana M., Liu, Fan, Furlotte, Nicholas A., Evans, David M., Bataille, Veronique, Visconti, Alessia, Hemani, Gibran, McMahon, George, Ring, Susan M., Smith, George Davey, Duffy, David L., Zhu, Gu, Gordon, Scott D., Medland, Sarah E., Lin, Bochao D., Willemsen, Gonneke, Jan Hottenga, Jouke, Vuckovic, Dragana, Girotto, Giorgia, Gandin, Ilaria, Sala, Cinzia, Concas, Maria Pina, Brumat, Marco, Gasparini, Paolo, Toniolo, Daniela, Cocca, Massimiliano, Robino, Antonietta, Yazar, Seyhan, Hewitt, Alex W., Chen, Yan, Zeng, Changqing, Uitterlinden, Andre G., Ikram, M. Arfan, Hamer, Merel A., van Duijn, Cornelia M., Nijsten, Tamar, Mackey, David A., Falchi, Mario, Boomsma, Dorret I., Martin, Nicholas G., Hinds, David A., Kayser, Manfred, Spector, Timothy D.

“…Hair color is one of the most recognizable visual traits in European populations and is under strong genetic control. Here we report the results of a…”
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The effects of pathogenic and likely pathogenic variants for inherited hemostasis disorders in 140 214 UK Biobank participants by Stefanucci, Luca, Collins, Janine, Sims, Matthew C., Barrio-Hernandez, Inigo, Sun, Luanluan, Burren, Oliver S., Perfetto, Livia, Bender, Isobel, Callahan, Tiffany J., Fleming, Kathryn, Guerrero, Jose A., Hermjakob, Henning, Martin, Maria J., Stephenson, James, Paneerselvam, Kalpana, Petrovski, Slavé, Porras, Pablo, Robinson, Peter N., Wang, Quanli, Watkins, Xavier, Frontini, Mattia, Laskowski, Roman A., Beltrao, Pedro, Di Angelantonio, Emanuele, Gomez, Keith, Laffan, Mike, Ouwehand, Willem H., Mumford, Andrew D., Freson, Kathleen, Carss, Keren, Downes, Kate, Gleadall, Nick, Megy, Karyn, Bruford, Elspeth, Vuckovic, Dragana

“…•Rare variants causal of recessive hemostasis disorders have clinical consequences in carriers.•Common variants modify these consequences and are one of the…”
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