Search Results - "Vucci, Kristina"

HER2 and HLA-A02 dual CAR-T cells utilize LOH in a NOT logic gate to address on-target off-tumor toxicity by Bassan, David, Weinberger, Leehee, Yi, Jason, Kim, Tanya, Weist, Michael R, Adams, Gregor B, Foord, Orit, Chaim, Neta, Tabak, Sarit, Bujanover, Nir, Lopesco, Yael, Vucci, Kristina, Schnair, Caitlin, Levy-Knafo, Limor, Kendall, Richard L, Calzone, Frank J, Sharbi-Yunger, Adi

“…BackgroundOne of the major challenges in chimeric antigen receptor (CAR)-T cell therapy for solid tumors is the potential for on-target off-tumor toxicity due…”
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316 Next generation CAR-T incorporating an inhibitory CAR (iCAR) for increased safety in solid tumors by Bassan, David, Weist, Michael, Weinberger, Leehee, Yi, Jason, Adams, Gregor, Kim, Tanya, Schnair, Caitlin, Vucci, Kristina, Tabak, Sarit, Neta Chaim, Bujanover, Nir, Lopesco, Yael, Levy-Kanfo, Limor, Foord, Orit, Johnston, Jim, Calzone, Frank, Kendell, Rick, Sharbi-Yunger, Adi

“…BackgroundChimeric antigen receptor (CAR)-T cell therapy has shown incredible clinical success for hematopoietic malignancies, but for solid tumors is limited…”
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Abstract 2848: Incorporation of inhibitory signaling domains into chimeric antigen receptors (iCAR) designed for self-regulation of canonical CAR-T to treat solid tumors by Bassan, David, Yi, Jason, Chaim, Neta, Bujanover, Nir, Tabak, Sarit, Kim, Tanya, Lopesco, Yael, Weinberger, Leehee, Vucci, Kristina, Weist, Michael, Schnair, Caitlin, Adams, Gregor B., Foord, Orit, Calzone, Frank J., Kendall, Rick, Sharbi-Yunger, Adi

“…Abstract Chimeric antigen receptor (CAR)-T cell therapy is a groundbreaking cancer treatment that has produced remarkable clinical efficacy for hematopoietic…”
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Abstract 2826: Rewiring CAR T-cells for absolute solid tumor specificity and safety by Weist, Michael R., Sharbi-Yunger, Adi, Yi, Jason, Schnair, Caitlin, Bassan, David, Kim, Tanya, Tabak, Sarit, Lopesco, Yael, Weinberger, Leehee, Bujanover, Nir, Chaim, Neta, Vucci, Kristina, Foord, Orit, Calzone, Frank J., Kendall, Rick, Adams, Gregor B.

“…Abstract Translation of the unprecedented efficacy of chimeric antigen receptor (CAR) T-cell technology into solid tumors requires a solution to the problem of…”
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Abstract 7034: Pooled CRISPR screening coupled with single-cell sequencing identifies modifiers of CAR T cell state in the context of chronic antigen stimulation by Joshi, Sahil, Wozniak, Glenn, Gagnon, John, Vucci, Kristina, Merrell, Allyson, Simon, Mandi, Oh, Catherine, Cardozo, Andrew, DeTomaso, David, Chow, Julie, Zheng, Grace, Boroughs, Angela, Joho, Keith, Thakore, Pratiksha, Oh, Soyoung, Freimer, Jake, Cass, Ashley, Sail, Vibhavari, Tocchini, Carla, Sandoval, Marian, Liu, Andrea, Cui, Eric, Drever, Matt, Galvin, Brendan, Milush, Jeff, Gray-Rupp, Levi, Wheeler, Emily, Chen, Bob, Levine, Jacob, Eidenschenk, Celine, Schartner, Jill, Geiger-Schuller, Katie, Huetter, Jan-Christian, Rutz, Sascha, Rozenblatt-Rosen, Orit, Mellman, Ira, Haining, W. Nicholas

“…Abstract T cell exhaustion resulting from chronic antigen stimulation and an immunosuppressive tumor microenvironment limits the efficacy of T cell therapies…”
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