Search Results - "Vu, Chi B"

Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes by Choy, Wendy, Sinclair, David A, Lambert, Philip D, Gagne, David J, Lynch, Amy V, Milne, Jill C, Bemis, Jean E, Boss, Olivier, Perni, Robert B, Schenk, Simon, Carney, David P, Yang, Hongying, Ng, Pui Yee, Iffland, Andre, Smith, Jesse J, Elliott, Peter J, Vu, Chi B, Xie, Roger, Galonek, Heidi, Israelian, Kristine, Lavu, Siva, Medvedik, Oliver, Olefsky, Jerrold M, Disch, Jeremy S, Nunes, Joseph J, Jirousek, Michael R, Westphal, Christoph H, Jin, Lei

“…Calorie restriction extends lifespan and produces a metabolic profile desirable for treating diseases of ageing such as type 2 diabetes. SIRT1, an…”
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Discovery of oxazolo[4,5- b]pyridines and related heterocyclic analogs as novel SIRT1 activators by Bemis, Jean E., Vu, Chi B., Xie, Roger, Nunes, Joseph J., Ng, Pui Yee, Disch, Jeremy S., Milne, Jill C., Carney, David P., Lynch, Amy V., Jin, Lei, Smith, Jesse J., Lavu, Siva, Iffland, Andre, Jirousek, Michael R., Perni, Robert B.

“…The identification and SAR of novel small molecule activators of SIRT1, which are structurally distinct and more potent than resveratrol ( 1), are described…”
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Fatty Acid Cysteamine Conjugates as Novel and Potent Autophagy Activators That Enhance the Correction of Misfolded F508del-Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) by Vu, Chi B, Bridges, Robert J, Pena-Rasgado, Cecilia, Lacerda, Antonio E, Bordwell, Curtis, Sewell, Abby, Nichols, Andrew J, Chandran, Sachin, Lonkar, Pallavi, Picarella, Dominic, Ting, Amal, Wensley, Allison, Yeager, Maisy, Liu, Feng

“…A depressed autophagy has previously been reported in cystic fibrosis patients with the common F508del-CFTR mutation. This report describes the synthesis and…”
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Synthesis and Characterization of Fatty Acid Conjugates of Niacin and Salicylic Acid by Vu, Chi B, Bemis, Jean E, Benson, Ericka, Bista, Pradeep, Carney, David, Fahrner, Richard, Lee, Diana, Liu, Feng, Lonkar, Pallavi, Milne, Jill C, Nichols, Andrew J, Picarella, Dominic, Shoelson, Adam, Smith, Jesse, Ting, Amal, Wensley, Allison, Yeager, Maisy, Zimmer, Michael, Jirousek, Michael R

“…This report describes the synthesis and preliminary biological characterization of novel fatty acid niacin conjugates and fatty acid salicylate conjugates…”
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Discovery of Imidazo[1,2-b]thiazole Derivatives as Novel SIRT1 Activators by Vu, Chi B, Bemis, Jean E, Disch, Jeremy S, Ng, Pui Yee, Nunes, Joseph J, Milne, Jill C, Carney, David P, Lynch, Amy V, Smith, Jesse J, Lavu, Siva, Lambert, Philip D, Gagne, David J, Jirousek, Michael R, Schenk, Simon, Olefsky, Jerrold M, Perni, Robert B

“…A series of imidazo[1,2-b]thiazole derivatives is shown to activate the NAD+-dependent deacetylase SIRT1, a potential new therapeutic target to treat various…”
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Quantitative Structure−Activity Relationships among Macrolide Antibacterial Agents:  In Vitro and in Vivo Potency against Pasteurella multocida by McFarland, James W, Berger, Cynthia M, Froshauer, Susan A, Hayashi, Shigeru F, Hecker, Scott J, Jaynes, Burton H, Jefson, Martin R, Kamicker, Barbara J, Lipinski, Christopher A, Lundy, Kristin M, Reese, Catherine P, Vu, Chi B

“…Quantitative structure−activity relationships have been found among macrolide antibacterial agents in their potencies against the bacterial pathogen…”
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CAT‐2003: A novel sterol regulatory element‐binding protein inhibitor that reduces steatohepatitis, plasma lipids, and atherosclerosis in apolipoprotein E3‐Leiden mice by Zimmer, Michael, Bista, Pradeep, Benson, Ericka L., Lee, Diana Y., Liu, Feng, Picarella, Dominic, Vega, Rick B., Vu, Chi B., Yeager, Maisy, Ding, Min, Liang, Guosheng, Horton, Jay D., Kleemann, Robert, Kooistra, Teake, Morrison, Martine C., Wielinga, Peter Y., Milne, Jill C., Jirousek, Michael R., Nichols, Andrew J.

“…CAT‐2003 is a novel conjugate of eicosapentaenoic acid (EPA) and niacin designed to be hydrolyzed by fatty acid amide hydrolase to release EPA inside cells at…”
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Discovery of benzothiazole derivatives as efficacious and enterocyte-specific MTP inhibitors by Vu, Chi B., Milne, Jill C., Carney, David P., Song, Jeffrey, Choy, Wendy, Lambert, Philip D., Gagne, David J., Hirsch, Michael, Cote, Angela, Davis, Meghan, Lainez, Elden, Meade, Nekeya, Normington, Karl, Jirousek, Michael R., Perni, Robert B.

“…A series of benzothiazole derivatives is shown to be potent MTP inhibitors, with some showing oral activity in a mice diet-induced obesity model. A series of…”
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Tricyclic Imidazoline Derivatives as Potent and Selective Adenosine A1 Receptor Antagonists by Vu, Chi B, Kiesman, William F, Conlon, Patrick R, Lin, Ko-Chung, Tam, Melissa, Petter, Russell C, Smits, Glenn, Lutterodt, Frank, Jin, Xiaowei, Chen, Liqing, Zhang, Jianbo

“…Novel tricyclic imidazoline antagonists of the adenosine A1 receptor are described. For key compounds, the selectivity level over other adenosine receptor…”
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Novel Diamino Derivatives of [1,2,4]Triazolo[1,5-a][1,3,5]triazine as Potent and Selective Adenosine A2a Receptor Antagonists by Vu, Chi B, Pan, Deborah, Peng, Bo, Kumaravel, Gnanasambandam, Smits, Glenn, Jin, Xiaowei, Phadke, Deepali, Engber, Thomas, Huang, Carol, Reilly, Jennifer, Tam, Stacy, Grant, Donna, Hetu, Gregg, Petter, Russell C

“…Piperazine derivatives of 2-furanyl[1,2,4]triazolo[1,5-a][1,3,5]triazine have recently been demonstrated to be potent and selective adenosine A2a receptor…”
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Triamino derivatives of triazolotriazine and triazolopyrimidine as adenosine A2a receptor antagonists by VU, Chi B, SHIELDS, Pamela, BO PENG, KUMARAVEL, Gnanasambandam, XIAOWEI JIN, PHADKE, Deepali, WANG, Joy, ENGBER, Thomas, AYYUB, Eman, PETTER, Russell C

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Piperazine Derivatives of [1,2,4]Triazolo[1,5-a][1,3,5]triazine as Potent and Selective Adenosine A2a Receptor Antagonists by VU, Chi B., PENG, Bo, KUMARAVEL, Gnanasambandam, SMITS, Glenn, JIN, Xiaowei, PHADKE, Deepali, ENGBER, Thomas, HUANG, Carol, REILLY, Jennifer, TAM, Stacy, GRANT, Donna, HETU, Gregg, CHEN, Liqing, ZHANG, Jianbo, PETTER, Russell C.

“…The [1,2,4]triazolo[1,5-a]triazine derivative 3, more commonly known in the field of adenosine research as ZM-241385, has previously been demonstrated to be a…”
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Bone-Targeted pyrido[2,3- d]pyrimidin-7-ones: potent inhibitors of Src tyrosine kinase as novel antiresorptive agents by Vu, Chi B., Luke, George P., Kawahata, Noriyuki, Shakespeare, William C., Wang, Yihan, Sundaramoorthi, Raji, Metcalf, Chester A., Keenan, Terence P., Pradeepan, Selvi, Corpuz, Evelyn, Merry, Taylor, Bohacek, Regine S., Dalgarno, David C., Narula, Surinder S., van Schravendijk, Marie Rose, Ram, Mary K., Adams, Susan, Liou, Shuenn, Keats, Jeffrey A., Violette, Shelia M., Guan, Wei, Weigele, Manfred, Sawyer, Tomi K.

“…The design of bone-targeted pyrido[2,3- d]pyrimidin-7-ones as Src tyrosine kinase inhibitors is described. Leveraging SAR from known compounds and using…”
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Studies on adenosine A2a receptor antagonists: comparison of three core heterocycles by VU, Chi B, PAN, Deborah, TAM, Stacy, PETTER, Russell C, BO PENG, LI SHA, KUMARAVEL, Gnanasambandam, XIAOWEI JIN, PHADKE, Deepali, ENGBER, Thomas, HUANG, Carol, REILLY, Jennifer

“…Piperazine and (R)-2-(aminomethyl)pyrrolidine derivatives of [1,2,4]triazolo[1,5-a][1,3,5]triazine have recently been shown to be potent and selective…”
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The chemistry of vicinal tricarbonyls. New routes to indolizidines by Wasserman, Harry H, Cook, Jan D, Vu, Chi B

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Discovery of Potent and Selective SH2 Inhibitors of the Tyrosine Kinase ZAP-70 by Vu, Chi B, Corpuz, Evelyn G, Merry, Taylor J, Pradeepan, Selvaluxmi G, Bartlett, Catherine, Bohacek, Regine S, Botfield, Martyn C, Eyermann, Charles J, Lynch, Berkley A, MacNeil, Ian A, Ram, Mary K, van Schravendijk, Marie Rose, Violette, Shelia, Sawyer, Tomi K

“…A series of 1,2,4-oxadiazole analogues has been shown to be potent and selective SH2 inhibitors of the tyrosine kinase ZAP-70, a potential therapeutic target…”
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Preservation of Mitochondrial Bioenergetics with CAT-4001 after Peroxide Injury by Thomson, Alexander H., Allen, Mitchell E., Perry, Justin B., Nichols, Andrew J., Reilly, John F., Bista, Pradeep, Lee, Diana, Vu, Chi B., Brown, David A.

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Selective Inhibition of Src SH2 by a Novel Thiol-Targeting Tricarbonyl-Modified Inhibitor and Mechanistic Analysis by 1H/ 13C NMR Spectroscopy by Sundaramoorthi, Raji, Siedem, Chris, Vu, Chi B, Dalgarno, David C, Laird, Ellen C, Botfield, Martyn C, Combs, Amanda B, Adams, Susan E, Yuan, Ruth W, Weigele, Manfred, Narula, Surinder S

“…Detailed analysis of Src SH2 binding by peptides containing a novel tricarbonyl-modified pTyr moiety is described. We envisaged that Src SH2 selectivity might…”
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Recent advances in the design and optimization of adenosine A2A receptor antagonists by Vu, Chi B

“…In recent years, the adenosine A2A receptor has gained interest as a potential therapeutic target for alleviating the symptoms of Parkinson's disease…”
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Novel Bicyclic Piperazine Derivatives of Triazolotriazine and Triazolopyrimidines as Highly Potent and Selective Adenosine A2A Receptor Antagonists by PENG, Hairuo, KUMARAVEL, Gnanasambandam, YAO, Gang, SHA, Li, WANG, Joy, VAN VLIJMEN, Herman, BOHNERT, Tonika, HUANG, Carol, VU, Chi B., ENSINGER, Carol L., CHANG, Hexi, ENGBER, Thomas M., WHALLEY, Eric T., PETTER, Russell C.

“…A series of bicyclic piperazine derivatives of triazolotriazine and triazolopyrimidines was synthesized. Some of these analogues show high affinity and…”
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