Search Results - "Vries, Robert G.J"

Identification of Multipotent Luminal Progenitor Cells in Human Prostate Organoid Cultures by Karthaus, Wouter R., Iaquinta, Phillip J., Drost, Jarno, Gracanin, Ana, van Boxtel, Ruben, Wongvipat, John, Dowling, Catherine M., Gao, Dong, Begthel, Harry, Sachs, Norman, Vries, Robert G.J., Cuppen, Edwin, Chen, Yu, Sawyers, Charles L., Clevers, Hans C.

“…The prostate gland consists of basal and luminal cells arranged as pseudostratified epithelium. In tissue recombination models, only basal cells reconstitute a…”
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Long-term Expansion of Epithelial Organoids From Human Colon, Adenoma, Adenocarcinoma, and Barrett's Epithelium by Sato, Toshiro, Stange, Daniel E, Ferrante, Marc, Vries, Robert G.J, van Es, Johan H, van den Brink, Stieneke, van Houdt, Winan J, Pronk, Apollo, van Gorp, Joost, Siersema, Peter D, Clevers, Hans

“…Background & Aims We previously established long-term culture conditions under which single crypts or stem cells derived from mouse small intestine expand over…”
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Long-Term In Vitro Expansion of Salivary Gland Stem Cells Driven by Wnt Signals by Maimets, Martti, Rocchi, Cecilia, Bron, Reinier, Pringle, Sarah, Kuipers, Jeroen, Giepmans, Ben N.G., Vries, Robert G.J., Clevers, Hans, de Haan, Gerald, van Os, Ronald, Coppes, Robert P.

“…Adult stem cells are the ultimate source for replenishment of salivary gland (SG) tissue. Self-renewal ability of stem cells is dependent on extrinsic niche…”
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Generation of L Cells in Mouse and Human Small Intestine Organoids by PETERSEN, Natalia, REIMANN, Frank, BARTFELD, Sina, FARIN, Henner F, RINGNALDA, Femke C, VRIES, Robert G. J, VAN DEN BRINK, Stieneke, CLEVERS, Hans, GRIBBLE, Fiona M, DE KONING, Eelco J. P

“…Upon a nutrient challenge, L cells produce glucagon-like peptide 1 (GLP-1), a powerful stimulant of insulin release. Strategies to augment endogenous GLP-1…”
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The SWI/SNF Chromatin-remodeling Complex Is a Cofactor for Tat Transactivation of the HIV Promoter by Mahmoudi, Tokameh, Parra, Maribel, Vries, Robert G.J., Kauder, Steven E., Verrijzer, C. Peter, Ott, Melanie, Verdin, Eric

“…Tat is a critical viral transactivator essential for human immunodeficiency virus (HIV) gene expression. Activation involves binding to an RNA stem-loop…”
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Rectal Organoids Enable Personalized Treatment of Cystic Fibrosis by Berkers, Gitte, van Mourik, Peter, Vonk, Annelotte M., Kruisselbrink, Evelien, Dekkers, Johanna F., de Winter-de Groot, Karin M., Arets, Hubertus G.M., Marck-van der Wilt, Rozemarijn E.P., Dijkema, Jasper S., Vanderschuren, Maaike M., Houwen, Roderick H.J., Heijerman, Harry G.M., van de Graaf, Eduard A., Elias, Sjoerd G., Majoor, Christof J., Koppelman, Gerard H., Roukema, Jolt, Bakker, Marleen, Janssens, Hettie M., van der Meer, Renske, Vries, Robert G.J., Clevers, Hans C., de Jonge, Hugo R., Beekman, Jeffrey M., van der Ent, Cornelis K.

“…In vitro drug tests using patient-derived stem cell cultures offer opportunities to individually select efficacious treatments. Here, we provide a study that…”
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A specific lysine in c-Jun is required for transcriptional repression by E1A and is acetylated by p300 by Vries, Robert G.J., Prudenziati, Michela, Zwartjes, Carin, Verlaan, Matty, Kalkhoven, Eric, Zantema, Alt

“…The adenovirus E1A protein regulates transcription of cellular genes via its interaction with the transcriptional coactivators p300/CBP. The collagenase…”
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Expansion of Adult Human Pancreatic Tissue Yields Organoids Harboring Progenitor Cells with Endocrine Differentiation Potential by Loomans, Cindy J.M., Williams Giuliani, Nerys, Balak, Jeetindra, Ringnalda, Femke, van Gurp, Léon, Huch, Meritxell, Boj, Sylvia F., Sato, Toshiro, Kester, Lennart, de Sousa Lopes, Susana M. Chuva, Roost, Matthias S., Bonner-Weir, Susan, Engelse, Marten A., Rabelink, Ton J., Heimberg, Harry, Vries, Robert G.J., van Oudenaarden, Alexander, Carlotti, Françoise, Clevers, Hans, de Koning, Eelco J.P.

“…Generating an unlimited source of human insulin-producing cells is a prerequisite to advance β cell replacement therapy for diabetes. Here, we describe a 3D…”
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Stem cells and cancer of the stomach and intestine by Vries, Robert G.J., Huch, Meritxell, Clevers, Hans

“…Cancer in the 21st century has become the number one cause of death in developed countries. Although much progress has been made in improving patient survival,…”
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Cancer-associated mutations in chromatin remodeler hSNF5 promote chromosomal instability by compromising the mitotic checkpoint by Vries, Robert G J, Bezrookove, Vladimir, Zuijderduijn, Lobke M P, Kia, Sima Kheradmand, Houweling, Ada, Oruetxebarria, Igor, Raap, Anton K, Verrijzer, C Peter

“…The hSNF5 subunit of human SWI/SNF ATP-dependent chromatin remodeling complexes is a tumor suppressor that is inactivated in malignant rhabdoid tumors (MRTs)…”
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p16 Is Required for hSNF5 Chromatin Remodeler-induced Cellular Senescence in Malignant Rhabdoid Tumor Cells by Oruetxebarria, Igor, Venturini, Francesca, Kekarainen, Tuija, Houweling, Ada, Zuijderduijn, Lobke M.P., Mohd-Sarip, Adone, Vries, Robert G.J., Hoeben, Rob C., Verrijzer, C. Peter

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Prospective Derivation of a Living Organoid Biobank of Colorectal Cancer Patients by van de Wetering, Marc, Francies, Hayley E., Francis, Joshua M., Bounova, Gergana, Iorio, Francesco, Pronk, Apollo, van Houdt, Winan, van Gorp, Joost, Taylor-Weiner, Amaro, Kester, Lennart, McLaren-Douglas, Anne, Blokker, Joyce, Jaksani, Sridevi, Bartfeld, Sina, Volckman, Richard, van Sluis, Peter, Li, Vivian S.W., Seepo, Sara, Sekhar Pedamallu, Chandra, Cibulskis, Kristian, Carter, Scott L., McKenna, Aaron, Lawrence, Michael S., Lichtenstein, Lee, Stewart, Chip, Koster, Jan, Versteeg, Rogier, van Oudenaarden, Alexander, Saez-Rodriguez, Julio, Vries, Robert G.J., Getz, Gad, Wessels, Lodewyk, Stratton, Michael R., McDermott, Ultan, Meyerson, Matthew, Garnett, Mathew J., Clevers, Hans

“…In Rspondin-based 3D cultures, Lgr5 stem cells from multiple organs form ever-expanding epithelial organoids that retain their tissue identity. We report the…”
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The Organoid Cell Atlas by Bock, Christoph, Boutros, Michael, Camp, J. Gray, Clarke, Laura, Clevers, Hans, Knoblich, Juergen A., Liberali, Prisca, Regev, Aviv, Rios, Anne C., Stegle, Oliver, Stunnenberg, Hendrik G., Teichmann, Sarah A., Treutlein, Barbara, Vries, Robert G. J.

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Organoid Models of Human and Mouse Ductal Pancreatic Cancer by Boj, Sylvia F., Hwang, Chang-Il, Baker, Lindsey A., Chio, Iok In Christine, Engle, Dannielle D., Corbo, Vincenzo, Jager, Myrthe, Ponz-Sarvise, Mariano, Tiriac, Hervé, Spector, Mona S., Gracanin, Ana, Oni, Tobiloba, Yu, Kenneth H., van Boxtel, Ruben, Huch, Meritxell, Rivera, Keith D., Wilson, John P., Feigin, Michael E., Öhlund, Daniel, Handly-Santana, Abram, Ardito-Abraham, Christine M., Ludwig, Michael, Elyada, Ela, Alagesan, Brinda, Biffi, Giulia, Yordanov, Georgi N., Delcuze, Bethany, Creighton, Brianna, Wright, Kevin, Park, Youngkyu, Morsink, Folkert H.M., Molenaar, I. Quintus, Borel Rinkes, Inne H., Cuppen, Edwin, Hao, Yuan, Jin, Ying, Nijman, Isaac J., Iacobuzio-Donahue, Christine, Leach, Steven D., Pappin, Darryl J., Hammell, Molly, Klimstra, David S., Basturk, Olca, Hruban, Ralph H., Offerhaus, George Johan, Vries, Robert G.J., Clevers, Hans, Tuveson, David A.

“…Pancreatic cancer is one of the most lethal malignancies due to its late diagnosis and limited response to treatment. Tractable methods to identify and…”
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Abstract LB-35: Living biobank of cancer organoids for drug development and screening by Vries, Robert G.J., Clevers, Hans

“…Future cancer therapy will rely on treatment with drugs that are specific for individual tumours and patients. However, predicting clinical responses from…”
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Paneth cell extrusion and release of antimicrobial products is directly controlled by immune cell-derived IFN-γ by Farin, Henner F, Karthaus, Wouter R, Kujala, Pekka, Rakhshandehroo, Maryam, Schwank, Gerald, Vries, Robert G J, Kalkhoven, Eric, Nieuwenhuis, Edward E S, Clevers, Hans

“…Paneth cells (PCs) are terminally differentiated, highly specialized secretory cells located at the base of the crypts of Lieberkühn in the small intestine…”
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Unlimited in vitro expansion of adult bi-potent pancreas progenitors through the Lgr5/R-spondin axis by Huch, Meritxell, Bonfanti, Paola, Boj, Sylvia F, Sato, Toshiro, Loomans, Cindy J M, van de Wetering, Marc, Sojoodi, Mozhdeh, Li, Vivian S W, Schuijers, Jurian, Gracanin, Ana, Ringnalda, Femke, Begthel, Harry, Hamer, Karien, Mulder, Joyce, van Es, Johan H, de Koning, Eelco, Vries, Robert G J, Heimberg, Harry, Clevers, Hans

“…Lgr5 marks adult stem cells in multiple adult organs and is a receptor for the Wnt‐agonistic R‐spondins (RSPOs). Intestinal, stomach and liver Lgr5 + stem…”
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Ongoing chromosomal instability and karyotype evolution in human colorectal cancer organoids by Bolhaqueiro, Ana C. F., Ponsioen, Bas, Bakker, Bjorn, Klaasen, Sjoerd J., Kucukkose, Emre, van Jaarsveld, Richard H., Vivié, Judith, Verlaan-Klink, Ingrid, Hami, Nizar, Spierings, Diana C. J., Sasaki, Nobuo, Dutta, Devanjali, Boj, Sylvia F., Vries, Robert G. J., Lansdorp, Peter M., van de Wetering, Marc, van Oudenaarden, Alexander, Clevers, Hans, Kranenburg, Onno, Foijer, Floris, Snippert, Hugo J. G., Kops, Geert J. P. L.

“…Chromosome segregation errors cause aneuploidy and genomic heterogeneity, which are hallmarks of cancer in humans. A persistent high frequency of these errors…”
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An FBXW7-ZEB2 axis links EMT and tumour microenvironment to promote colorectal cancer stem cells and chemoresistance by Li, Ningning, Babaei-Jadidi, Roya, Lorenzi, Federica, Spencer-Dene, Bradley, Clarke, Philip, Domingo, Enric, Tulchinsky, Eugene, Vries, Robert G. J., Kerr, David, Pan, Yihang, He, Yulong, Bates, David O., Tomlinson, Ian, Clevers, Hans, Nateri, Abdolrahman S.

“…Colorectal cancer (CRC) patients develop recurrence after chemotherapy owing to the survival of stem cell-like cells referred to as cancer stem-like cells…”
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Molecular and Functional Characterization of Human Intestinal Organoids and Monolayers for Modeling Epithelial Barrier by Jelinsky, Scott A, Derksen, Merel, Bauman, Eric, Verissimo, Carla S, van Dooremalen, Wies T M, Roos, Jamie Lee, Higuera Barón, Celia, Caballero-Franco, Celia, Johnson, Bryce G, Rooks, Michelle G, Pott, Johanna, Oldenburg, Bas, Vries, Robert G J, Boj, Sylvia F, Kasaian, Marion T, Pourfarzad, Farzin, Rosadini, Charles V

“…Abstract Background Patient-derived organoid (PDO) models offer potential to transform drug discovery for inflammatory bowel disease (IBD) but are limited by…”
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