Search Results - "Vries, René"

Strong and Sustained Antihypertensive Effect of Small Interfering RNA Targeting Liver Angiotensinogen by Uijl, Estrellita, Mirabito Colafella, Katrina M, Sun, Yuan, Ren, Liwei, van Veghel, Richard, Garrelds, Ingrid M, de Vries, René, Poglitsch, Marko, Zlatev, Ivan, Kim, Jae B, Hoorn, Ewout J, Foster, Don, Danser, A.H Jan

“…Small interfering RNAs (siRNAs) targeting hepatic angiotensinogen (Agt) may provide long-lasting antihypertensive effects, but the optimal approach remains…”
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Crossreactivity to vinculin and microbes provides a molecular basis for HLA-based protection against rheumatoid arthritis by van Heemst, Jurgen, Jansen, Diahann T. S. L., Polydorides, Savvas, Moustakas, Antonis K., Bax, Marieke, Feitsma, Anouk L., Bontrop-Elferink, Diënne G., Baarse, Martine, van der Woude, Diane, Wolbink, Gert-Jan, Rispens, Theo, Koning, Frits, de Vries, René R. P., Papadopoulos, George K., Archontis, Georgios, Huizinga, Tom W., Toes, René E.

“…The HLA locus is the strongest risk factor for anti-citrullinated protein antibody (ACPA) + rheumatoid arthritis (RA). Despite considerable efforts in the last…”
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Intracellular pathways of calcitonin gene‐related peptide‐induced relaxation of human coronary arteries: A key role for Gβγ subunit instead of cAMP by Vries, Tessa, Labruijere, Sieneke, Rivera‐Mancilla, Eduardo, Garrelds, Ingrid M., Vries, René, Schutter, Dennis, Bogaerdt, Antoon, Poyner, David R., Ladds, Graham, Danser, A. H. Jan, MaassenVanDenBrink, Antoinette

“…Background and Purpose Calcitonin gene‐related peptide (CGRP) is a potent vasodilator. While its signalling is assumed to be mediated via increases in cAMP,…”
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The interaction between HLA shared epitope alleles and smoking and its contribution to autoimmunity against several citrullinated antigens by Willemze, Annemiek, van der Woude, Diane, Ghidey, Wendimagegn, Levarht, E. W. Nivine, Stoeken‐Rijsbergen, Gerrie, Verduyn, Willem, de Vries, René R. P., Houwing‐Duistermaat, Jeanine J., Huizinga, Tom W. J., Trouw, Leendert A., Toes, René E. M.

“…Objective Recent data suggest that a gene–environment interaction between smoking and the HLA shared epitope alleles plays a role in shaping the autoimmune…”
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Genetics of rheumatoid arthritis: time for a change by de Vries, René

“…PURPOSE OF REVIEWTo review recent progress in the genetics of rheumatoid arthritis (RA) and discuss the implications for understanding the pathogenesis of the…”
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Gene-environment interaction influences the reactivity of autoantibodies to citrullinated antigens in rheumatoid arthritis by van der Woude, Diane, Alemayehu, Wendimagegn Ghidey, Verduijn, Willem, de Vries, René R P, Houwing-Duistermaat, Jeanine J, Huizinga, Tom W J, Toes, René E M

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Soluble guanylate cyclase activator BAY 54–6544 improves vasomotor function and survival in an accelerated ageing mouse model by Ataei Ataabadi, Ehsan, Golshiri, Keivan, Jüttner, Annika A., Vries, René, den Berg‐Garrelds, Ingrid, Nagtzaam, Nicole M. A., Khan, Hina N., Leijten, Frank P. J., Brandt, Renata M. C., Dik, Willem A., Pluijm, Ingrid, Danser, A. H. Jan, Sandner, Peter, Roks, Anton J. M.

“…DNA damage is a causative factor in ageing of the vasculature and other organs. One of the most important vascular ageing features is reduced nitric oxide…”
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Pharmacological characterization of VIP and PACAP receptors in the human meningeal and coronary artery by Chan, Kayi Y, Baun, Michael, de Vries, René, van den Bogaerdt, Antoon J, Dirven, Clemens M F, Danser, Alexander H J, Jansen-Olesen, Inger, Olesen, Jes, Villalón, Carlos M, MaassenVanDenBrink, Antoinette, Gupta, Saurabh

“…We pharmacologically characterized pituitary adenylate cyclase-activating polypeptides (PACAPs), vasoactive intestinal peptide (VIP) and the VPAC(1), VPAC(2)…”
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Chronic Sildenafil Treatment Improves Vasomotor Function in a Mouse Model of Accelerated Aging by Golshiri, Keivan, Ataei Ataabadi, Ehsan, Brandt, Renata, van der Pluijm, Ingrid, de Vries, René, Danser, Jan, Roks, Anton

“…Aging leads to a loss of vasomotor control. Both vasodilation and vasoconstriction are affected. Decreased nitric oxide-cGMP-mediated relaxation is a hallmark…”
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Cyclooxygenase-2 inhibition prevents renal toxicity but not hypertension during sunitinib treatment by van Dorst, Daan C H, Mirabito Colafella, Katrina M, van Veghel, Richard, Garrelds, Ingrid M, de Vries, René, Mathijssen, Ron H J, Danser, A H Jan, Versmissen, Jorie

“…Anticancer angiogenesis inhibitors cause hypertension and renal injury. Previously we observed in rats that high-dose aspirin (capable of blocking…”
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COVID-19 outbreaks among crew on commercial ships at the Port of Rotterdam, the Netherlands, 2020 to 2021 by Gebuis, Edward, Vieyra, Bruno, Slegtenhorst, Rob, Wiegmans, Saskia, van Dijk, Bas, Veenstra, Thijs, Tejland, Saskia, Fanoy, Ewout, de Raad, Annemieke, Koopmans, Marion, de Vries, René, van Leeuwen-Voerman, Saskia, Whelan, Jane

“…BackgroundDuring the COVID-19 pandemic, international shipping activity was disrupted as movement of people and goods was restricted. The Port of Rotterdam,…”
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Angiotensin–neprilysin inhibition confers renoprotection in rats with diabetes and hypertension by limiting podocyte injury by Uijl, Estrellita, ‘t Hart, Daan C., Roksnoer, Lodi C.W., Groningen, Marian C. Clahsen-van, van Veghel, Richard, Garrelds, Ingrid M., de Vries, René, van der Vlag, Johan, Zietse, Robert, Nijenhuis, Tom, Joles, Jaap A., Hoorn, Ewout J., Danser, A.H. Jan

“…OBJECTIVES:Combined angiotensin receptor--neprilysin inhibition (ARNI) reduces glomerulosclerosis better than single angiotensin receptor blockade (ARB) in…”
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English translation of the dutch blood transfusion guideline 2011 by de Vries, René, Haas, Fred

“…Amended and new recommendations in the present version of the Blood Transfusion Guideline (compared with the previous version) have been marked in the text in…”
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Selective Phosphodiesterase 1 Inhibition Ameliorates Vascular Function, Reduces Inflammatory Response, and Lowers Blood Pressure in Aging Animals by Golshiri, Keivan, Ataei Ataabadi, Ehsan, Rubio-Beltran, Eloísa, Dutheil, Sophie, Yao, Wei, Snyder, Gretchen L, Davis, Robert E, van der Pluijm, Ingrid, Brandt, Renata, Van den Berg-Garrelds, Ingrid M, MaassenVanDenBrink, Antoinette, de Vries, René, Danser, A H Jan, Roks, Anton J M

“…Diminished nitric oxide-cGMP-mediated relaxation plays a crucial role in cardiovascular aging, leading to decreased vasodilation, vascular hypertrophy and…”
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Protective effect of noninherited maternal HLA-DR antigens on rheumatoid arthritis development by Feitsma, Anouk L, Worthington, Jane, van der Helm-van Mil, Annette H.M, Plant, Darren, Thomson, Wendy, Ursum, Jennie, van Schaardenburg, Dirkjan, van der Horst-Bruinsma, Irene E, van Rood, Jon J, Huizinga, Tom W.J, Toes, René E.M, de Vries, René R.P

“…Rheumatoid arthritis (RA) is a complex genetic disorder in which the HLA-region contributes most to the genetic risk. HLA-DRB1-molecules containing the amino…”
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The Effects of Acute and Chronic Selective Phosphodiesterase 1 Inhibition on Smooth Muscle Cell-Associated Aging Features by Golshiri, Keivan, Ataabadi, Ehsan Ataei, Jüttner, Annika A, Snyder, Gretchen L, Davis, Robert E, Lin, Amy, Zhang, Lei, de Vries, René, Garrelds, Ingrid M, Leijten, Frank P J, Danser, A H Jan, Roks, Anton J M

“…Age-related cardiovascular diseases (CVDs) remain among the leading global causes of death, and vascular smooth muscle cell (VSMC) remodeling plays an…”
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Prorenin is the endogenous agonist of the (pro)renin receptor. Binding kinetics of renin and prorenin in rat vascular smooth muscle cells overexpressing the human (pro)renin receptor by Batenburg, Wendy W, Krop, Manne, Garrelds, Ingrid M, de Vries, René, de Bruin, René JA, Burcklé, Celine A, Müller, Dominik N, Bader, Michael, Nguyen, Geneviève, Danser, AH Jan

“…OBJECTIVEMannose 6-phosphate receptors (M6PR) bind both renin and prorenin, and such binding contributes to renin/prorenin clearance but not to angiotensin…”
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Neprilysin inhibition and endothelin-1 elevation: Focus on the kidney by Roksnoer, Lodi C.W., Uijl, Estrellita, de Vries, René, Garrelds, Ingrid M., Jan Danser, A.H.

“…Increasing the degree of renin-angiotensin system (RAS) blockade by combining ≥2 RAS blockers marginally increases efficacy, but results in more side effects…”
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Vascular Ageing Features Caused by Selective DNA Damage in Smooth Muscle Cell by Ataei Ataabadi, Ehsan, Golshiri, Keivan, van der Linden, Janette, de Boer, Martine, Duncker, Dirk J., Jüttner, Annika, de Vries, René, Van Veghel, Richard, van der Pluijm, Ingrid, Dutheil, Sophie, Chalgeri, Suman, Zhang, Lei, Lin, Amy, Davis, Robert E., Snyder, Gretchen L., Danser, A. H. Jan, Roks, Anton J. M.

“…Persistently unrepaired DNA damage has been identified as a causative factor for vascular ageing. We have previously shown that a defect in the function or…”
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Effect of the calcitonin gene-related peptide (CGRP) receptor antagonist telcagepant in human cranial arteries by Edvinsson, Lars, Chan, Kayi Y, Eftekhari, Sajedeh, Nilsson, Elisabeth, de Vries, René, Säveland, Hans, Dirven, Clemens M F, Danser, A H Jan, MaassenVanDenBrink, Antoinette

“…Calcitonin gene-related peptide (CGRP) is a neuronal messenger in intracranial sensory nerves and is considered to play a significant role in migraine…”
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