Search Results - "Vriend, Lianne E."

Effects of hyperthermia on DNA repair pathways: one treatment to inhibit them all by Oei, Arlene L, Vriend, Lianne E M, Crezee, Johannes, Franken, Nicolaas A P, Krawczyk, Przemek M

“…The currently available arsenal of anticancer modalities includes many DNA damaging agents that can kill malignant cells. However, efficient DNA repair…”
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Engineering large-scale chromosomal deletions by CRISPR-Cas9 by Eleveld, Thomas F, Bakali, Chaimaa, Eijk, Paul P, Stathi, Phylicia, Vriend, Lianne E, Poddighe, Pino J, Ylstra, Bauke

“…Abstract Large-scale chromosomal deletions are a prevalent and defining feature of cancer. A high degree of tumor-type and subtype specific recurrencies…”
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Distinct genetic control of homologous recombination repair of Cas9-induced double-strand breaks, nicks and paired nicks by Vriend, Lianne E M, Prakash, Rohit, Chen, Chun-Chin, Vanoli, Fabio, Cavallo, Francesca, Zhang, Yu, Jasin, Maria, Krawczyk, Przemek M

“…DNA double-strand breaks (DSBs) are known to be powerful inducers of homologous recombination (HR), but single-strand breaks (nicks) have also been shown to…”
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Hepatitis c virus-specific t-cell-derived transforming growth factor beta is associated with slow hepatic fibrogenesis by Li, Shaoyong, Vriend, Lianne E.M., Nasser, Imad A., Popov, Yury, Afdhal, Nezam H., Koziel, Margaret J., Schuppan, Detlef, Exley, Mark A., Alatrakchi, Nadia

“…Hepatitis C virus (HCV)‐specific immune effector responses can cause liver damage in chronic infection. Hepatic stellate cells (HSC) are the main effectors of…”
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Gene-dosage dependent overexpression at the 13q amplicon identifies DIS3 as candidate oncogene in colorectal cancer progression by de Groen, Florence L.M., Krijgsman, Oscar, Tijssen, Marianne, Vriend, Lianne E.M., Ylstra, Bauke, Hooijberg, Erik, Meijer, Gerrit A., Steenbergen, Renske D.M., Carvalho, Beatriz

“…Colorectal cancer (CRC) development is in most cases marked by the accumulation of genomic alterations including gain of the entire q‐arm of chromosome 13…”
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Meta-analysis of DNA double-strand break response kinetics by Kochan, Jakub A, Desclos, Emilie C B, Bosch, Ruben, Meister, Luna, Vriend, Lianne E M, van Attikum, Haico, Krawczyk, Przemek M

“…Most proteins involved in the DNA double-strand break response (DSBR) accumulate at the damage sites, where they perform functions related to damage signaling,…”
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Nick-initiated homologous recombination: Protecting the genome, one strand at a time by Vriend, Lianne E.M., Krawczyk, Przemek M.

“…Homologous recombination (HR) is an essential, widely conserved mechanism that utilizes a template for accurate repair of DNA breaks. Some early HR models,…”
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Fucose-based PAMPs prime dendritic cells for follicular T helper cell polarization via DC-SIGN-dependent IL-27 production by Gringhuis, Sonja I., Kaptein, Tanja M., Wevers, Brigitte A., van der Vlist, Michiel, Klaver, Elsenoor J., van Die, Irma, Vriend, Lianne E. M., de Jong, Marein A. W. P., Geijtenbeek, Teunis B. H.

“…Dendritic cells (DCs) orchestrate antibody-mediated responses to combat extracellular pathogens including parasites by initiating T helper cell…”
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Invariant NKT cell-augmented GM-CSF-secreting tumor vaccine is effective in advanced prostate cancer model by Varghese, Bindu, Lynch, Lydia, Vriend, Lianne E., Draganov, Dobrin, Clark, Justice M., Kissick, Haydn T., Varghese, Sharlin, Sanda, Martin G., Dranoff, Glenn, Arredouani, M. Simo, Balk, Steven P., Exley, Mark A.

“…Invariant natural killer T cells (iNKT cells) express a semi-invariant T cell receptor that recognizes certain glycolipids (including α-galactosylceramide,…”
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Assaying break and nick-induced homologous recombination in mammalian cells using the DR-GFP reporter and Cas9 nucleases by Vriend, Lianne E M, Jasin, Maria, Krawczyk, Przemek M

“…Thousands of DNA breaks occur daily in mammalian cells, including potentially tumorigenic double-strand breaks (DSBs) and less dangerous but vastly more…”
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Ultra-soft X-ray system for imaging the early cellular responses to X-ray induced DNA damage by Kochan, Jakub A, van den Belt, Matthias, von der Lippe, Julia, Desclos, Emilie C B, Steurer, Barbara, Hoebe, Ron A, Scutigliani, Enzo M, Verhoeven, Jan, Stap, Jan, Bosch, Ruben, Rijpkema, Meindert, van Oven, Carel, van Veen, Henk A, Stellingwerf, Irene, Vriend, Lianne E M, Marteijn, Jurgen A, Aten, Jacob A, Krawczyk, Przemek M

“…The majority of the proteins involved in processing of DNA double-strand breaks (DSBs) accumulate at the damage sites. Real-time imaging and analysis of these…”
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WEE1 inhibition and genomic instability in cancer by Vriend, Lianne E.M., De Witt Hamer, Philip C., Van Noorden, Cornelis J.F., Würdinger, Thomas

“…One of the hallmarks of cancer is genomic instability controlled by cell cycle checkpoints. The G1 and G2 checkpoints allow DNA damage responses, whereas the…”
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C-type lectin Langerin is a β-glucan receptor on human Langerhans cells that recognizes opportunistic and pathogenic fungi by de Jong, Marein A.W.P., Vriend, Lianne E.M., Theelen, Bart, Taylor, Maureen E., Fluitsma, Donna, Boekhout, Teun, Geijtenbeek, Teunis B.H.

“…Langerhans cells (LCs) lining the stratified epithelia and mucosal tissues are the first antigen presenting cells to encounter invading pathogens, such as…”
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Boosting the effects of hyperthermia-based anticancer treatments by HSP90 inhibition by Vriend, Lianne E M, van den Tempel, Nathalie, Oei, Arlene L, L'Acosta, Mike, Pieterson, Frederique J, Franken, Nicolaas A P, Kanaar, Roland, Krawczyk, Przemek M

“…Hyperthermia - application of supra-physiological temperatures to cells, tissues or organs - is a pleiotropic treatment that affects most aspects of cellular…”
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Sensitizing thermochemotherapy with a PARP1-inhibitor by Oei, Arlene L, Vriend, Lianne E M, van Leeuwen, Caspar M, Rodermond, Hans M, Ten Cate, Rosemarie, Westermann, Anneke M, Stalpers, Lukas J A, Crezee, Johannes, Kanaar, Roland, Kok, H Petra, Krawczyk, Przemek M, Franken, Nicolaas A P

“…Cis-diamminedichloroplatinum(II) (cisplatin, cDDP) is an effective chemotherapeutic agent that induces DNA double strand breaks (DSBs), primarily in…”
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C-type lectin Langerin is a b-glucan receptor on human Langerhans cells that recognizes opportunistic and pathogenic fungi by De Jong, Marein AWP, Vriend, Lianne EM, Theelen, Bart, Taylor, Maureen E, Fluitsma, Donna, Boekhout, Teun, Geijtenbeek, Teunis BH

“…Langerhans cells (LCs) lining the stratified epithelia and mucosal tissues are the first antigen presenting cells to encounter invading pathogens, such as…”
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