Search Results - "Vriend, Jelle"

Flow stimulates drug transport in a human kidney proximal tubule-on-a-chip independent of primary cilia by Vriend, Jelle, Peters, Janny G.P., Nieskens, Tom T.G., Škovroňová, Renata, Blaimschein, Nina, Schmidts, Miriam, Roepman, Ronald, Schirris, Tom J.J., Russel, Frans G.M., Masereeuw, Rosalinde, Wilmer, Martijn J.

“…Kidney disease modeling and assessment of drug-induced kidney injury can be advanced using three-dimensional (3D) microfluidic models that recapitulate in vivo…”
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Organic anion transporters 1 and 3 influence cellular energy metabolism in renal proximal tubule cells by Vriend, Jelle, Hoogstraten, Charlotte A, Venrooij, Kevin R, van den Berge, Bartholomeus T, Govers, Larissa P, van Rooij, Arno, Huigen, Marleen C D G, Schirris, Tom J J, Russel, Frans G M, Masereeuw, Rosalinde, Wilmer, Martijn J

“…Organic anion transporters (OATs) 1 and 3 are, besides being uptake transporters, key in several cellular metabolic pathways. The underlying mechanisms are…”
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10% Body weight (gain) change as criterion for the maximum tolerated dose: A critical analysis by van Berlo, Damiën, Woutersen, Marjolijn, Muller, Andre, Pronk, Marja, Vriend, Jelle, Hakkert, Betty

“…The concept of the Maximum Tolerated Dose (MTD) was introduced in the seventies for carcinogenicity testing and was defined as the highest dose inducing clear…”
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Rebuttal to the letter to the editors regarding Van Berlo et al. (2022) paper titled “10% Body weight (gain) change as criterion for the maximum tolerated dose: A critical analysis” by van Berlo, Damiën, Woutersen, Marjolijn, Muller, Andre, Pronk, Marja, Vriend, Jelle, Hakkert, Betty

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Rebuttal to the letter to the editors regarding Van Berlo et al. (2022) paper titled “10% body weight (gain) change as criterion for the maximum tolerated dose: A critical analysis” by Berlo, Damiën van, Woutersen, Marjolijn, Muller, Andre, Pronk, Marja, Vriend, Jelle, Hakkert, Betty

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Nephrotoxicity and Kidney Transport Assessment on 3D Perfused Proximal Tubules by Vormann, Marianne K., Gijzen, Linda, Hutter, Simon, Boot, Lisette, Nicolas, Arnaud, van den Heuvel, Angelique, Vriend, Jelle, Ng, Chee Ping, Nieskens, Tom T. G., van Duinen, Vincent, de Wagenaar, Bjorn, Masereeuw, Rosalinde, Suter-Dick, Laura, Trietsch, Sebastiaan J., Wilmer, Martijn, Joore, Jos, Vulto, Paul, Lanz, Henriette L.

“…Proximal tubules in the kidney play a crucial role in reabsorbing and eliminating substrates from the body into the urine, leading to high local concentrations…”
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In vitro models for accurate prediction of renal tubular xenobiotic transport in vivo by Vriend, Jelle, Pye, Keith R., Brown, Colin

“…The proximal tubule is of key interest in drug discovery due to its primary role in the excretion and reabsorption of xenobiotics. It is increasingly important…”
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Screening of Drug-Transporter Interactions in a 3D Microfluidic Renal Proximal Tubule on a Chip by Vriend, Jelle, Nieskens, Tom T. G., Vormann, Marianne K., van den Berge, Bartholomeus T., van den Heuvel, Angelique, Russel, Frans G. M., Suter-Dick, Laura, Lanz, Henriëtte L., Vulto, Paul, Masereeuw, Rosalinde, Wilmer, Martijn J.

“…Drug-transporter interactions could impact renal drug clearance and should ideally be detected in early stages of drug development to avoid toxicity-related…”
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Animal-free safety assessment of chemicals: an innovation system perspective by Hoogstraaten, Marjolein J, Vriend, Jelle, de Leeuw, Victoria C, Negro, Simona O, Moors, Ellen H M, Kienhuis, Anne S, Hoekman, Jarno

“…This perspective paper, which is the result of a collaborative effort between toxicologists and scholars in innovation and transition studies, presents a…”
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The role of trust in the use of artificial intelligence for chemical risk assessment by Wassenaar, Pim N.H., Minnema, Jordi, Vriend, Jelle, Peijnenburg, Willie J.G.M., Pennings, Jeroen L.A., Kienhuis, Anne

“…Risk assessment of chemicals is a time-consuming process and needs to be optimized to ensure all chemicals are timely evaluated and regulated. This transition…”
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Rebuttal to the letter to the editors regarding paper titled "10% Body weight (gain) change as criterion for the maximum tolerated dose: A critical analysis" by van Berlo, Damiën, Woutersen, Marjolijn, Muller, Andre, Pronk, Marja, Vriend, Jelle, Hakkert, Betty

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Renal toxicity biomarker analysis upon compound exposures in a kidney-on-a-chip by Wilmer, Martijn, Vriend, Jelle, Nieskens, Tom, Lanz, Henriëtte, Vormann, Marianne, Gijzen, Linda, Ramp, Daniella, Suter-Dick, Laura, Masereeuw, Roos, Vulto, Paul

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Nephroscreen: A robust and versatile renal tubule-on-a-chip platform for nephrotoxicity assessment by Vriend, Jelle, Vormann, Marianne K., Lanz, Henriëtte L., Joore, Jos, Trietsch, Sebastiaan J., Russel, Frans G.M., Jacobsen, Björn, Roth, Adrian, Lu, Shuyan, Polli, Joseph W., Naidoo, Anita A., Masereeuw, Rosalinde, Wilmer, Martijn J., Suter-Dick, Laura

“…Proximal tubule epithelial cells are the main driver of renal transport and secretion of xenobiotics, making them susceptible to drug-induced kidney injury…”
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PPARγ signaling is required for mediating EETs protective effects in neonatal cardiomyocytes exposed to LPS by Samokhvalov, Victor, Vriend, Jelle, Jamieson, Kristi L, Akhnokh, Maria K, Manne, Rajkumar, Falck, John R, Seubert, John M

“…Lipopolysaccharide (LPS) is a bacterial wall endotoxin producing many pathophysiological conditions including myocardial inflammation leading to…”
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CYP epoxygenase metabolites of docosahexaenoic acid protect HL-1 cardiac cells against LPS-induced cytotoxicity through SIRT1 by Samokhvalov, V, Jamieson, K L, Vriend, J, Quan, S, Seubert, J M

“…Bacterial LPS is an environmental toxin capable of promoting various cardiac complications. Current evidence suggests that LPS-induced myocardial dysfunction…”
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PPARγ signaling is required for mediating EETs protective effects in neonatal cardiomyocytes exposed to LPS by Samokhvalov, Victor, Vriend, Jelle, Jamieson, Kristi L., Akhnokh, Maria K., Manne, Rajkumar, Falck, John R., Seubert, John M.

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