Search Results - "Vrielink, Alice"

Development of a novel spatiotemporal depletion system for cellular cholesterol by Pham, Ha, Singaram, Indira, Sun, Jiachen, Ralko, Arthur, Puckett, Madalyn, Sharma, Ashutosh, Vrielink, Alice, Cho, Wonhwa

“…Cholesterol is an essential component of mammalian cell membranes whose subcellular concentration and function are tightly regulated by de novo biosynthesis,…”
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Enzymatic toxins from snake venom: structural characterization and mechanism of catalysis by Kang, Tse Siang, Georgieva, Dessislava, Genov, Nikolay, Murakami, Mário T., Sinha, Mau, Kumar, Ramasamy P., Kaur, Punit, Kumar, Sanjit, Dey, Sharmistha, Sharma, Sujata, Vrielink, Alice, Betzel, Christian, Takeda, Soichi, Arni, Raghuvir K., Singh, Tej P., Kini, R. Manjunatha

“…Snake venoms are cocktails of enzymes and non‐enzymatic proteins used for both the immobilization and digestion of prey. The most common snake venom enzymes…”
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High‐pressure single‐crystal diffraction at the Australian Synchrotron by Boer, Stephanie A., Price, Jason R., Riboldi-Tunnicliffe, Alan, Williamson, Rachel, Rostan, Robert, Summers, Aston, Turner, Gemma F., Jones, Isabelle, Bond, Charles S., Vrielink, Alice, Marshall, Andrew C., Hitchings, John, Moggach, Stephen A.

“…A new high‐pressure single‐crystal diffraction setup has been designed and implemented at the Australian Synchrotron for collecting molecular and protein…”
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Conserved and Novel Functions for Arabidopsis thaliana MIA40 in Assembly of Proteins in Mitochondria and Peroxisomes by Carrie, Chris, Giraud, Estelle, Duncan, Owen, Xu, Lin, Wang, Yan, Huang, Shaobai, Clifton, Rachel, Murcha, Monika, Filipovska, Aleksandra, Rackham, Oliver, Vrielink, Alice, Whelan, James

“…The disulfide relay system of the mitochondrial intermembrane space has been extensively characterized in Saccharomyces cerevisiae. It contains two essential…”
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Structure-Function Relationships of the Neisserial EptA Enzyme Responsible for Phosphoethanolamine Decoration of Lipid A: Rationale for Drug Targeting by Kahler, Charlene M, Nawrocki, K L, Anandan, A, Vrielink, Alice, Shafer, William M

“…Bacteria cause disease by two general mechanisms: the action of their toxins on host cells and induction of a pro-inflammatory response that can lead to a…”
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Ligand recognition by the TPR domain of the import factor Toc64 from Arabidopsis thaliana by Panigrahi, Rashmi, Adina-Zada, Abdussalam, Whelan, James, Vrielink, Alice

“…The specific targeting of protein to organelles is achieved by targeting signals being recognised by their cognate receptors. Cytosolic chaperones, bound to…”
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Cholesterol oxidase: ultrahigh-resolution crystal structure and multipolar atom model-based analysis by Zarychta, Bartosz, Lyubimov, Artem, Ahmed, Maqsood, Munshi, Parthapratim, Guillot, Benoît, Vrielink, Alice, Jelsch, Christian

“…Examination of protein structure at the subatomic level is required to improve the understanding of enzymatic function. For this purpose, X‐ray diffraction…”
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An extended N-H bond, driven by a conserved second-order interaction, orients the flavin N5 orbital in cholesterol oxidase by Golden, Emily, Yu, Li-Juan, Meilleur, Flora, Blakeley, Matthew P., Duff, Anthony P., Karton, Amir, Vrielink, Alice

“…The protein microenvironment surrounding the flavin cofactor in flavoenzymes is key to the efficiency and diversity of reactions catalysed by this class of…”
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Conformational flexibility of EptA driven by an interdomain helix provides insights for enzyme–substrate recognition by Anandan, Anandhi, Dunstan, Nicholas W, Ryan, Timothy M, Mertens, Haydyn D.T, Lim, Katherine Y.L, Evans, Genevieve L, Kahler, Charlene M, Vrielink, Alice

“…Many pathogenic gram-negative bacteria have developed mechanisms to increase resistance to cationic antimicrobial peptides by modifying the lipid A moiety. One…”
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The role of oxidoreductases in determining the function of the neisserial lipid A phosphoethanolamine transferase required for resistance to polymyxin by Piek, Susannah, Wang, Zhirui, Ganguly, Jhuma, Lakey, Adam M, Bartley, Stephanie N, Mowlaboccus, Shakeel, Anandan, Anandhi, Stubbs, Keith A, Scanlon, Martin J, Vrielink, Alice, Azadi, Parastoo, Carlson, Russell W, Kahler, Charlene M

“…The decoration of the lipid A headgroups of the lipooligosaccharide (LOS) by the LOS phosphoethanolamine (PEA) transferase (LptA) in Neisseria spp. is central…”
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Molecular Features of the Copper Binding Sites in the Octarepeat Domain of the Prion Protein by Burns, Colin S, Aronoff-Spencer, Eliah, Dunham, Christine M, Lario, Paula, Avdievich, Nikolai I, Antholine, William E, Olmstead, Marilyn M, Vrielink, Alice, Gerfen, Gary J, Peisach, Jack, Scott, William G, Millhauser, Glenn L

“…Recent evidence suggests that the prion protein (PrP) is a copper binding protein. The N-terminal region of human PrP contains four sequential copies of the…”
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Lipid A Phosphoethanolamine Transferase: Regulation, Structure and Immune Response by Samantha, Ariela, Vrielink, Alice

“…A wide variety of antibiotics are targeted to the bacterial membrane due to its unique arrangement and composition relative to the host mammalian membranes. By…”
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Crystal Structure of a Bifunctional Aldolase-Dehydrogenase: Sequestering a Reactive and Volatile Intermediate by Manjasetty, Babu A., Powlowski, Justin, Vrielink, Alice

“…The crystal structure of the bifunctional enzyme 4-hydroxy-2-ketovalerate aldolase (DmpG)/acylating acetaldehyde dehydrogenase (DmpF), which is involved in the…”
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Sub-atomic Resolution Crystal Structure of Cholesterol Oxidase: What Atomic Resolution Crystallography Reveals about Enzyme Mechanism and the Role of the FAD Cofactor in Redox Activity by Lario, Paula I., Sampson, Nicole, Vrielink, Alice

“…The crystal structure of cholesterol oxidase, a 56kDa flavoenzyme was anisotropically refined to 0.95Å resolution. The final crystallographic R-factor and…”
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PPARα and PPARγ activation is associated with pleural mesothelioma invasion but therapeutic inhibition is ineffective by Orozco Morales, M. Lizeth, Rinaldi, Catherine A., de Jong, Emma, Lansley, Sally M., Gummer, Joel P.A., Olasz, Bence, Nambiar, Shabarinath, Hope, Danika E., Casey, Thomas H., Lee, Y. C. Gary, Leslie, Connull, Nealon, Gareth, Shackleford, David M., Powell, Andrew K., Grimaldi, Marina, Balaguer, Patrick, Zemek, Rachael M., Bosco, Anthony, Piggott, Matthew J., Vrielink, Alice, Lake, Richard A., Lesterhuis, W. Joost

“…Mesothelioma is a cancer that typically originates in the pleura of the lungs. It rapidly invades the surrounding tissues, causing pain and shortness of…”
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Structure and function of lipid A–modifying enzymes by Anandan, Anandhi, Vrielink, Alice

“…Lipopolysaccharides are complex molecules found in the cell envelop of many Gram‐negative bacteria. The toxic activity of these molecules has led to the…”
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Oxygen Access to the Active Site of Cholesterol Oxidase through a Narrow Channel Is Gated by an Arg-Glu Pair by Coulombe, R, Yue, K Q, Ghisla, S, Vrielink, A

“…Cholesterol oxidase is a monomeric flavoenzyme that catalyzes the oxidation and isomerization of cholesterol to cholest-4-en-3-one. Two forms of the enzyme are…”
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The first transcriptomes from field-collected individual whiteflies ( Bemisia tabaci , Hemiptera: Aleyrodidae):  a case study of the endosymbiont composition by Sseruwagi, Peter, Wainaina, James, Ndunguru, Joseph, Tumuhimbise, Robooni, Tairo, Fred, Guo, Jian-Yang, Vrielink, Alice, Blythe, Amanda, Kinene, Tonny, De Marchi, Bruno, Kehoe, Monica A, Tanz, Sandra, Boykin, Laura M

“…species ( ), or whiteflies, are the world's most devastating insect pests. They cause billions of dollars (US) of damage each year, and are leaving farmers in…”
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Atomic resolution crystallography reveals how changes in pH shape the protein microenvironment by Moustafa, Ibrahim, Vrielink, Alice, Lario, Paula I, Lyubimov, Artem Y

“…Hydrogen atoms are a vital component of enzyme structure and function. In recent years, atomic resolution crystallography (≥1.2 Å) has been successfully used…”
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Cholesterol oxidase: biochemistry and structural features by Vrielink, Alice, Ghisla, Sandro

“…Cholesterol oxidases are bifunctional flavoenzymes that catalyze the oxidation of steroid substrates which have a hydroxyl group at the 3β position of the…”
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