Search Results - "Vrieling, Frank"

Triglyceride breakdown from lipid droplets regulates the inflammatory response in macrophages by van Dierendonck, Xanthe A M H, Vrieling, Frank, Smeehuijzen, Lisa, Deng, Lei, Boogaard, Joline P, Croes, Cresci-Anne, Temmerman, Lieve, Wetzels, Suzan, Biessen, Erik, Kersten, Sander, Stienstra, Rinke

“…In response to inflammatory activation by pathogens, macrophages accumulate triglycerides in intracellular lipid droplets. The mechanisms underlying…”
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Metabolic heterogeneity of tissue-resident macrophages in homeostasis and during helminth infection by Heieis, Graham A., Patente, Thiago A., Almeida, Luís, Vrieling, Frank, Tak, Tamar, Perona-Wright, Georgia, Maizels, Rick M., Stienstra, Rinke, Everts, Bart

“…Tissue-resident macrophage populations constitute a mosaic of phenotypes, yet how their metabolic states link to the range of phenotypes and functions in vivo…”
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Macrophages take up VLDL-sized emulsion particles through caveolae-mediated endocytosis and excrete part of the internalized triglycerides as fatty acids by Deng, Lei, Vrieling, Frank, Stienstra, Rinke, Hooiveld, Guido J, Feitsma, Anouk L, Kersten, Sander

“…Triglycerides are carried in the bloodstream as part of very low-density lipoproteins (VLDLs) and chylomicrons, which represent the triglyceride-rich…”
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Author Correction: Metabolic heterogeneity of tissue-resident macrophages in homeostasis and during helminth infection by Heieis, Graham A., Patente, Thiago A., Almeida, Luís, Vrieling, Frank, Tak, Tamar, Perona-Wright, Georgia, Maizels, Rick M., Stienstra, Rinke, Everts, Bart

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Analyzing the impact of Mycobacterium tuberculosis infection on primary human macrophages by combined exploratory and targeted metabolomics by Vrieling, Frank, Kostidis, Sarantos, Spaink, Herman P., Haks, Mariëlle C., Mayboroda, Oleg A., Ottenhoff, Tom H. M., Joosten, Simone A.

“…The pathogenic success of Mycobacterium tuberculosis ( Mtb ) is tightly linked to its ability to recalibrate host metabolic processes in infected host…”
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Oxidized low-density lipoprotein (oxLDL) supports Mycobacterium tuberculosis survival in macrophages by inducing lysosomal dysfunction by Vrieling, Frank, Wilson, Louis, Rensen, Patrick C N, Walzl, Gerhard, Ottenhoff, Tom H M, Joosten, Simone A

“…Type 2 diabetes mellitus (DM) is a major risk factor for developing tuberculosis (TB). TB-DM comorbidity is expected to pose a serious future health problem…”
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Lipid accumulation in adipose tissue-resident iNKT cells contributes to an inflammatory phenotype by Morris, Imogen, Vrieling, Frank, Bouwman, Annemieke, Stienstra, Rinke, Kalkhoven, Eric

“…Reciprocal communication between adipocytes and immune cells is essential to maintain optimal adipose tissue (AT) functionality. Amongst others, adipocytes…”
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Functional Inhibition of Host Histone Deacetylases (HDACs) Enhances in vitro and in vivo Anti-mycobacterial Activity in Human Macrophages and in Zebrafish by Moreira, Jôsimar D, Koch, Bjørn E V, van Veen, Suzanne, Walburg, Kimberley V, Vrieling, Frank, Mara Pinto Dabés Guimarães, Tânia, Meijer, Annemarie H, Spaink, Herman P, Ottenhoff, Tom H M, Haks, Mariëlle C, Heemskerk, Matthias T

“…The rapid and persistent increase of drug-resistant ( ) infections poses increasing global problems in combatting tuberculosis (TB), prompting for the…”
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The effect of hyperglycaemia on in vitro cytokine production and macrophage infection with Mycobacterium tuberculosis by Lachmandas, Ekta, Vrieling, Frank, Wilson, Louis G, Joosten, Simone A, Netea, Mihai G, Ottenhoff, Tom H, van Crevel, Reinout

“…Type 2 diabetes mellitus is an established risk factor for tuberculosis but the underlying mechanisms are largely unknown. We examined the effects of…”
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Pyruvate Dehydrogenase Kinase Inhibitor Dichloroacetate Improves Host Control of Salmonella enterica Serovar Typhimurium Infection in Human Macrophages by van Doorn, Cassandra L R, Schouten, Gina K, van Veen, Suzanne, Walburg, Kimberley V, Esselink, Jeroen J, Heemskerk, Matthias T, Vrieling, Frank, Ottenhoff, Tom H M

“…Global increases in the prevalence of antimicrobial resistance highlight the urgent need for novel strategies to combat infectious diseases. Recent studies…”
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Patients with Concurrent Tuberculosis and Diabetes Have a Pro-Atherogenic Plasma Lipid Profile by Vrieling, Frank, Ronacher, Katharina, Kleynhans, Léanie, van den Akker, Erik, Walzl, Gerhard, Ottenhoff, Tom H.M., Joosten, Simone A.

“…Type 2 diabetes mellitus (DM) is a major risk factor for development of tuberculosis (TB), however the underlying molecular foundations are unclear. Since…”
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The effects of sulfated secondary bile acids on intestinal barrier function and immune response in an inflammatory in vitro human intestinal model by van der Lugt, Benthe, Vos, Maartje C.P., Grootte Bromhaar, Mechteld, Ijssennagger, Noortje, Vrieling, Frank, Meijerink, Jocelijn, Steegenga, Wilma T.

“…Dysbiosis-related perturbations in bile acid (BA) metabolism were observed in inflammatory bowel disease (IBD) patients, which was characterized by increased…”
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Are postprandial glucose responses sufficiently person-specific to use in personalized dietary advice? Design of the RepEAT study: a fully controlled dietary intervention to determine the variation in glucose responses by Daanje, Monique, Siebelink, Els, Vrieling, Frank, van den Belt, Maartje, van der Haar, Sandra, Gerdessen, Johanna C, Kersten, Sander, Esser, Diederik, Afman, Lydia A

“…An elevated postprandial glucose response is associated with an increased risk of cardiometabolic diseases. Existing research suggests large heterogeneity in…”
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Obesity and dysregulated innate immune responses: impact of micronutrient deficiencies by Vrieling, Frank, Stienstra, Rinke

“…The presence of obesity is associated with dysregulated innate immune responses, including macrophages.The research field of immunometabolism dictates that…”
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Plasma metabolomics in tuberculosis patients with and without concurrent type 2 diabetes at diagnosis and during antibiotic treatment by Vrieling, Frank, Alisjahbana, Bachti, Sahiratmadja, Edhyana, van Crevel, Reinout, Harms, Amy C., Hankemeier, Thomas, Ottenhoff, Tom H. M., Joosten, Simone A.

“…Tuberculosis (TB) and type 2 diabetes mellitus (DM), a major TB risk factor, are both accompanied by marked alterations in metabolic processes. Dissecting the…”
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Immunometabolic Signatures of Circulating Monocytes in Humans With Obesity and Insulin Resistance by Smeehuijzen, Lisa, Gijbels, Anouk, Nugteren-Boogaard, Joline P, Vrieling, Frank, Boutagouga Boudjadja, Mehdi, Trouwborst, Inez, Jardon, Kelly M, Hul, Gabby B, Feskens, Edith J M, Blaak, Ellen E, Goossens, Gijs H, Afman, Lydia A, Stienstra, Rinke

“…Obesity is associated with chronic inflammation and metabolic complications, including insulin resistance (IR). Immune cells drive inflammation through the…”
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Tumor-derived cyclooxygenase-2 fuels hypothalamic inflammation by Li, Xiaolin, Zhu, Xinxia, Diba, Parham, Shi, Xuan, Vrieling, Frank, Jansen, Fleur A.C., Balvers, Michiel G.J., de Bus, Ian, Levasseur, Peter R., Sattler, Ariana, Arneson-Wissink, Paige C., Poland, Mieke, Witkamp, Renger F., van Norren, Klaske, Marks, Daniel L.

“…•Tumor-derived Prostaglandin E2 (via COX-2) and host gut-originated LPS synergistically amplify hypothalamic inflammation in vitro and in vivo.•Prostaglandin…”
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Oxidized low-density lipoprotein by Vrieling, Frank, Wilson, Louis, Rensen, Patrick C. N, Walzl, Gerhard, Ottenhoff, Tom H. M, Joosten, Simone A

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Milk fat globule membrane modulates inflammatory pathways in human monocytes: A crossover human intervention study by Deng, Lei, Michielsen, Charlotte C.J.R., Vrieling, Frank, Hooiveld, Guido J.E.J., Stienstra, Rinke, Feitsma, Anouk L., Kersten, Sander, Afman, Lydia A.

“…Intake of high-fat foods raises postprandial plasma triglycerides and inflammatory markers, which may depend on the type of fat ingested. Dairy products are…”
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An Internet-Based Psychological Intervention With a Serious Game to Improve Vitality, Psychological and Physical Condition, and Immune Function in Healthy Male Adults: Randomized Controlled Trial by Schakel, Lemmy, Veldhuijzen, Dieuwke S, van Middendorp, Henriët, Prins, Corine, Drittij, Anne M H F, Vrieling, Frank, Visser, Leo G, Ottenhoff, Tom H M, Joosten, Simone A, Evers, Andrea W M

“…Recently, internet-based cognitive behavioral therapy (ICBT) and serious gaming interventions have been suggested to enhance accessibility to interventions and…”
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