Search Results - "Vreeken, Rob"

Potent peptidic fusion inhibitors of influenza virus by Kadam, Rameshwar U., Juraszek, Jarek, Brandenburg, Boerries, Buyck, Christophe, Schepens, Wim B. G., Kesteleyn, Bart, Stoops, Bart, Vreeken, Rob J., Vermond, Jan, Goutier, Wouter, Tang, Chan, Vogels, Ronald, Friesen, Robert H. E., Goudsmit, Jaap, van Dongen, Maria J. P., Wilson, Ian A.

“…Influenza therapeutics with new targets and mechanisms of action are urgently needed to combat potential pandemics, emerging viruses, and constantly mutating…”
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Increase in short-chain ceramides correlates with an altered lipid organization and decreased barrier function in atopic eczema patients[S] by Janssens, Michelle, van Smeden, Jeroen, Gooris, Gert S., Bras, Wim, Portale, Guiseppe, Caspers, Peter J., Vreeken, Rob J., Hankemeier, Thomas, Kezic, Sanja, Wolterbeek, Ron, Lavrijsen, Adriana P., Bouwstra, Joke A.

“…A hallmark of atopic eczema (AE) is skin barrier dysfunction. Lipids in the stratum corneum (SC), primarily ceramides, fatty acids, and cholesterol, are…”
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LC/MS analysis of stratum corneum lipids: ceramide profiling and discovery[S] by van Smeden, Jeroen, Hoppel, Louise, van der Heijden, Rob, Hankemeier, Thomas, Vreeken, Rob J., Bouwstra, Joke A.

“…Ceramides (CERs) in the upper layer of the skin, the stratum corneum (SC), play a key role in the skin barrier function. In human SC, the literature currently…”
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Enhanced lipid isomer separation in human plasma using reversed-phase UPLC with ion-mobility/high-resolution MS detection[S] by Damen, Carola W.N., Isaac, Giorgis, Langridge, James, Hankemeier, Thomas, Vreeken, Rob J.

“…An ultraperformance LC (UPLC) method for the separation of different lipid molecular species and lipid isomers using a stationary phase incorporating charged…”
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The importance of free fatty acid chain length for the skin barrier function in atopic eczema patients by van Smeden, Jeroen, Janssens, Michelle, Kaye, Edward C. J., Caspers, Peter J., Lavrijsen, Adriana P., Vreeken, Rob J., Bouwstra, Joke A.

“…An important feature of atopic eczema (AE) is a decreased skin barrier function. The stratum corneum (SC) lipids – comprised of ceramides (CERs), free fatty…”
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A branched biosynthetic pathway is involved in production of roquefortine and related compounds in Penicillium chrysogenum by Ali, Hazrat, Ries, Marco I, Nijland, Jeroen G, Lankhorst, Peter P, Hankemeier, Thomas, Bovenberg, Roel A L, Vreeken, Rob J, Driessen, Arnold J M

“…Profiling and structural elucidation of secondary metabolites produced by the filamentous fungus Penicillium chrysogenum and derived deletion strains were used…”
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Quantitative mass spectrometry imaging of drugs and metabolites: a multiplatform comparison by Lamont, Lieke, Hadavi, Darya, Viehmann, Brent, Flinders, Bryn, Heeren, Ron M. A., Vreeken, Rob J., Porta Siegel, Tiffany

“…Mass spectrometry imaging (MSI) provides insight into the molecular distribution of a broad range of compounds and, therefore, is frequently applied in the…”
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Metabolomics profiling for identification of novel potential markers in early prediction of preeclampsia by Kuc, Sylwia, Koster, Maria P H, Pennings, Jeroen L A, Hankemeier, Thomas, Berger, Ruud, Harms, Amy C, Dane, Adrie D, Schielen, Peter C J I, Visser, Gerard H A, Vreeken, Rob J

“…The first aim was to investigate specific signature patterns of metabolites that are significantly altered in first-trimester serum of women who subsequently…”
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Combined LC/MS-platform for analysis of all major stratum corneum lipids, and the profiling of skin substitutes by van Smeden, Jeroen, Boiten, Walter A., Hankemeier, Thomas, Rissmann, Robert, Bouwstra, Joke A., Vreeken, Rob J.

“…Ceramides (CERs), cholesterol, and free fatty acids (FFAs) are the main lipid classes in human stratum corneum (SC, outermost skin layer), but no studies…”
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Ionisation efficiencies can be predicted in complicated biological matrices: A proof of concept by Liigand, Piia, Liigand, Jaanus, Cuyckens, Filip, Vreeken, Rob J., Kruve, Anneli

“…The importance of metabolites is assessed based on their abundance. Most of the metabolites are at present identified based on ESI/MS measurements and the…”
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Infrared ion spectroscopy: New opportunities for small-molecule identification in mass spectrometry - A tutorial perspective by Martens, Jonathan, van Outersterp, Rianne E., Vreeken, Rob J., Cuyckens, Filip, Coene, Karlien L.M., Engelke, Udo F., Kluijtmans, Leo A.J., Wevers, Ron A., Buydens, Lutgarde M.C., Redlich, Britta, Berden, Giel, Oomens, Jos

“…Combining the individual analytical strengths of mass spectrometry and infrared spectroscopy, infrared ion spectroscopy is increasingly recognized as a…”
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Enhanced Sensitivity Using MALDI Imaging Coupled with Laser Postionization (MALDI-2) for Pharmaceutical Research by Barré, Florian P. Y, Paine, Martin R. L, Flinders, Bryn, Trevitt, Adam J, Kelly, Patrick D, Ait-Belkacem, Rima, Garcia, João P, Creemers, Laura B, Stauber, Jonathan, Vreeken, Rob J, Cillero-Pastor, Berta, Ellis, Shane R, Heeren, Ron M. A

“…Visualizing the distributions of drugs and their metabolites is one of the key emerging application areas of matrix-assisted laser desorption/ionization–mass…”
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Comprehensive LC−MSE Lipidomic Analysis using a Shotgun Approach and Its Application to Biomarker Detection and Identification in Osteoarthritis Patients by Castro-Perez, Jose M, Kamphorst, Jurre, DeGroot, Jeroen, Lafeber, Floris, Goshawk, Jeff, Yu, Kate, Shockcor, John P, Vreeken, Rob J, Hankemeier, Thomas

“…A fast and robust method for lipid profiling utilizing liquid chromatography coupled with mass spectrometry has been demonstrated and validated for the…”
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Quantitative profiling of oxylipins through comprehensive LC-MS/MS analysis: application in cardiac surgery by Strassburg, Katrin, Huijbrechts, Annemarie M. L., Kortekaas, Kirsten A., Lindeman, Jan H., Pedersen, Theresa L., Dane, Adrie, Berger, Ruud, Brenkman, Arjan, Hankemeier, Thomas, van Duynhoven, John, Kalkhoven, Eric, Newman, John W., Vreeken, Rob J.

“…Oxylipins, including eicosanoids, affect a broad range of biological processes, such as the initiation and resolution of inflammation. These compounds, also…”
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Mass spectrometric recommendations for Quan/Qual analysis using liquid-chromatography coupled to quadrupole time-of-flight mass spectrometry by Dubbelman, Anne-Charlotte, Cuyckens, Filip, Dillen, Lieve, Gross, Gerhard, Vreeken, Rob J., Hankemeier, Thomas

“…High-throughput simultaneous quantitative and qualitative (Quan/Qual) analysis is attractive to combine targeted with non-targeted analysis, e.g. in…”
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Intercellular Skin Barrier Lipid Composition and Organization in Netherton Syndrome Patients by van Smeden, Jeroen, Janssens, Michelle, Boiten, Walter A., van Drongelen, Vincent, Furio, Laetitia, Vreeken, Rob J., Hovnanian, Alain, Bouwstra, Joke A.

“…Netherton syndrome (NTS) is a rare genetic skin disease caused by mutations in the serine protease inhibitor Kazal-type 5 gene, which encodes the…”
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Lipidomics of familial longevity by Gonzalez‐Covarrubias, Vanessa, Beekman, Marian, Uh, Hae‐Won, Dane, Adrie, Troost, Jorne, Paliukhovich, Iryna, Kloet, Frans M., Houwing‐Duistermaat, Jeanine, Vreeken, Rob J., Hankemeier, Thomas, Slagboom, Eline P.

“…Summary Middle‐aged offspring of nonagenarians, as compared to their spouses (controls), show a favorable lipid metabolism marked by larger LDL particle size…”
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Three-Phase Electroextraction: A New (Online) Sample Purification and Enrichment Method for Bioanalysis by Raterink, Robert-Jan, Lindenburg, Peter W, Vreeken, Rob J, Hankemeier, Thomas

“…The migration and at the same time enrichment of analytes from a liquid aqueous sample donor phase through an immiscible organic solvent layer acting as a…”
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Development and application of a UHPLC–MS/MS metabolomics based comprehensive systemic and tissue-specific screening method for inflammatory, oxidative and nitrosative stress by Schoeman, Johannes C., Harms, Amy C., van Weeghel, Michel, Berger, Ruud, Vreeken, Rob J., Hankemeier, Thomas

“…Oxidative stress and inflammation are underlying pathogenic mechanisms associated with the progression of several pathological conditions and immunological…”
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Metabolic Phenotyping Reveals a Lipid Mediator Response to Ionizing Radiation by Laiakis, Evagelia C, Strassburg, Katrin, Bogumil, Ralf, Lai, Steven, Vreeken, Rob J, Hankemeier, Thomas, Langridge, James, Plumb, Robert S, Fornace, Albert J, Astarita, Giuseppe

“…Exposure to ionizing radiation has dramatically increased in modern society, raising serious health concerns. The molecular response to ionizing radiation,…”
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