Search Results - "Vranka, Janice A"

Extracellular matrix in the trabecular meshwork: Intraocular pressure regulation and dysregulation in glaucoma by Vranka, Janice A., Kelley, Mary J., Acott, Ted S., Keller, Kate E.

“…The trabecular meshwork (TM) is located in the anterior segment of the eye and is responsible for regulating the outflow of aqueous humor. Increased resistance…”
Get full text

Estimating Human Trabecular Meshwork Stiffness by Numerical Modeling and Advanced OCT Imaging by Wang, Ke, Johnstone, Murray A, Xin, Chen, Song, Shaozhen, Padilla, Steven, Vranka, Janice A, Acott, Ted S, Zhou, Kai, Schwaner, Stephen A, Wang, Ruikang K, Sulchek, Todd, Ethier, C Ross

“…The purpose of this study was to estimate human trabecular meshwork (hTM) stiffness, thought to be elevated in glaucoma, using a novel indirect approach, and…”
Get full text

Mapping molecular differences and extracellular matrix gene expression in segmental outflow pathways of the human ocular trabecular meshwork by Vranka, Janice A, Bradley, John M, Yang, Yong-Feng, Keller, Kate E, Acott, Ted S

“…Elevated intraocular pressure (IOP) is the primary risk factor for glaucoma, and lowering IOP remains the only effective treatment for glaucoma. The trabecular…”
Get full text

Biochemical Characterization of the Prolyl 3-Hydroxylase 1·Cartilage-associated Protein·Cyclophilin B Complex by Ishikawa, Yoshihiro, Wirz, Jackie, Vranka, Janice A., Nagata, Kazuhiro, Bächinger, Hans Peter

“…The rough endoplasmic reticulum-resident protein complex consisting of prolyl 3-hydroxylase 1 (P3H1), cartilage-associated protein (CRTAP), and cyclophilin B…”
Get full text

Inhibition of hyaluronan synthesis reduces versican and fibronectin levels in trabecular meshwork cells by Keller, Kate E, Sun, Ying Ying, Vranka, Janice A, Hayashi, Lauren, Acott, Ted S

“…Hyaluronan (HA) is a major component of the extracellular matrix (ECM) and is synthesized by three HA synthases (HAS). Similarities between the HAS2 knockout…”
Get full text

Normal and glaucomatous outflow regulation by Acott, Ted S., Vranka, Janice A., Keller, Kate E., Raghunathan, VijayKrishna, Kelley, Mary J.

“…Glaucoma remains only partially understood, particularly at the level of intraocular pressure (IOP) regulation. Trabecular meshwork (TM) and Schlemm's canal…”
Get full text

Pressure-induced expression changes in segmental flow regions of the human trabecular meshwork by Vranka, Janice A., Acott, Ted S.

“…Elevated intraocular pressure (IOP) is thought to create distortion or stretching of the juxtacanalicular and Schlemm’s canal cells and their extracellular…”
Get full text

Influence of dexamethasone-induced matrices on the TM transcriptome by Soundappan, Keerti, Cai, Jingwen, Yu, Hongfang, Dhamodaran, Kamesh, Baidouri, Hasna, Vranka, Janice A., Xu, Hongyan, Raghunathan, Vijaykrishna, Liu, Yutao

“…Pathologic bidirectional interactions between the extracellular matrix (ECM) and cells within the human trabecular meshwork (hTM) contribute to ocular…”
Get full text

Circumferential trabecular meshwork cell density in the human eye by Kuehn, Markus H., Vranka, Janice A., Wadkins, David, Jackson, Thomas, Cheng, Lin, Ledolter, Johannes

“…The cells residing in the trabecular meshwork (TM) fulfill important roles in the maintenance of the tissue and the regulation of intraocular pressure (IOP)…”
Get full text

Biomechanical Rigidity and Quantitative Proteomics Analysis of Segmental Regions of the Trabecular Meshwork at Physiologic and Elevated Pressures by Vranka, Janice A, Staverosky, Julia A, Reddy, Ashok P, Wilmarth, Phillip A, David, Larry L, Acott, Ted S, Russell, Paul, Raghunathan, Vijay Krishna

“…The extracellular matrix (ECM) of the trabecular meshwork (TM) modulates resistance to aqueous humor outflow, thereby regulating IOP. Glaucoma, a leading cause…”
Get full text

Prolyl 3-Hydroxylase 1, Enzyme Characterization and Identification of a Novel Family of Enzymes by Vranka, Janice A., Sakai, Lynn Y., Bächinger, Hans Peter

“…The collagen prolyl hydroxylases are enzymes that are required for proper collagen biosynthesis, folding, and assembly. They reside within the endoplasmic…”
Get full text

Elevated pressure influences relative distribution of segmental regions of the trabecular meshwork by Vranka, Janice A., Staverosky, Julia A., Raghunathan, VijayKrishna, Acott, Ted S.

“…Elevated intraocular pressure (IOP) is the primary risk factor for glaucoma and is the only treatable feature of the disease. There is a correlation between…”
Get full text

Endogenous expression of Notch pathway molecules in human trabecular meshwork cells by Dhamodaran, Kamesh, Baidouri, Hasna, Nartey, Andrews, Staverosky, Julia, Keller, Kate, Acott, Ted, Vranka, Janice A, Raghunathan, Vijay Krishna

“…Cells in the trabecular meshwork sense and respond to a myriad of physical forces through a process known as mechanotransduction. Whilst the effect of…”
Get full text

Segmental versican expression in the trabecular meshwork and involvement in outflow facility by Keller, Kate E, Bradley, John M, Vranka, Janice A, Acott, Ted S

“…Versican is a large proteoglycan with numerous chondroitin sulfate (CS) glycosaminoglycan (GAG) side chains attached. To assess versican's potential…”
Get full text

Characterization of extracellular matrix deposited by segmental trabecular meshwork cells by Raghunathan, VijayKrishna, Nartey, Andrews, Dhamodaran, Kamesh, Baidouri, Hasna, Staverosky, Julia A., Keller, Kate E., Zientek, Keith, Reddy, Ashok, Acott, Ted, Vranka, Janice A.

“…Biophysical and biochemical attributes of the extracellular matrix are major determinants of cell fate in homeostasis and disease. Ocular hypertension and…”
Get full text

Intraocular pressure homeostasis: maintaining balance in a high-pressure environment by Acott, Ted S, Kelley, Mary J, Keller, Kate E, Vranka, Janice A, Abu-Hassan, Diala W, Li, Xinbo, Aga, Mini, Bradley, John M

“…Although glaucoma is a relatively common blinding disease, most people do not develop glaucoma. A robust intraocular pressure (IOP) homeostatic mechanism keeps…”
Get more information

Mutation in Cyclophilin B That Causes Hyperelastosis Cutis in American Quarter Horse Does Not Affect Peptidylprolyl cis-trans Isomerase Activity but Shows Altered Cyclophilin B-Protein Interactions and Affects Collagen Folding by Ishikawa, Yoshihiro, Vranka, Janice A., Boudko, Sergei P., Pokidysheva, Elena, Mizuno, Kazunori, Zientek, Keith, Keene, Douglas R., Rashmir-Raven, Ann M., Nagata, Kazuhiro, Winand, Nena J., Bächinger, Hans Peter

“…The rate-limiting step of folding of the collagen triple helix is catalyzed by cyclophilin B (CypB). The G6R mutation in cyclophilin B found in the American…”
Get full text

Bone matrix hypermineralization in prolyl-3 hydroxylase 1 deficient mice by Fratzl-Zelman, Nadja, Bächinger, Hans-Peter, Vranka, Janice A, Roschger, Paul, Klaushofer, Klaus, Rauch, Frank

“…Abstract Lack of prolyl 3-hydroxylase 1 (P3H1) due to mutations in P3H1 results in severe forms of recessive osteogenesis imperfecta. In the present study, we…”
Get full text

Posttranslational Modifications in Type I Collagen from Different Tissues Extracted from Wild Type and Prolyl 3-Hydroxylase 1 Null Mice by Pokidysheva, Elena, Zientek, Keith D., Ishikawa, Yoshihiro, Mizuno, Kazunori, Vranka, Janice A., Montgomery, Nathan T., Keene, Douglas R., Kawaguchi, Tatsuya, Okuyama, Kenji, Bächinger, Hans Peter

“…Type I collagen extracted from tendon, skin, and bone of wild type and prolyl 3-hydroxylase 1 (P3H1) null mice shows distinct patterns of 3-hydroxylation and…”
Get full text

Prolyl 3-Hydroxylase 1 Null Mice Display Abnormalities in Fibrillar Collagen-rich Tissues Such as Tendons, Skin, and Bones by Vranka, Janice A., Pokidysheva, Elena, Hayashi, Lauren, Zientek, Keith, Mizuno, Kazunori, Ishikawa, Yoshihiro, Maddox, Kerry, Tufa, Sara, Keene, Douglas R., Klein, Robert, Bächinger, Hans Peter

“…Osteogenesis imperfecta (OI) is a skeletal disorder primarily caused by mutations in the type I collagen genes. However, recent investigations have revealed…”
Get full text