Search Results - "Vranic, Mladen"

Ubiquitinated-Protein Aggregates Form in Pancreatic β-Cells During Diabetes-Induced Oxidative Stress and Are Regulated by Autophagy by KANIUK, Natalia A, KIRALY, Michael, BATES, Holly, VRANIC, Mladen, VOLCHUK, Allen, BRUMELL, John H

“…Ubiquitinated-Protein Aggregates Form in Pancreatic β-Cells During Diabetes-Induced Oxidative Stress and Are Regulated by Autophagy Natalia A. Kaniuk 1 ,…”
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Somatostatin Receptor Type 2 Antagonism Improves Glucagon and Corticosterone Counterregulatory Responses to Hypoglycemia in Streptozotocin-Induced Diabetic Rats by YUE, Jessica T. Y, BURDETT, Elena, COY, David H, GIACCA, Adria, EFENDIC, Suad, VRANIC, Mladen

“…Diminished responsiveness to hypoglycemia contributes to defective counterregulation in diabetes. Pancreatic and/or circulating somatostatin are elevated in…”
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Glucagon secretion and signaling in the development of diabetes by Gaisano, Herbert Y, Macdonald, Patrick E, Vranic, Mladen

“…Normal release of glucagon from pancreatic islet α-cells promotes glucose mobilization, which counteracts the hypoglycemic actions of insulin, thereby ensuring…”
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Regular exercise prevents the development of hyperglucocorticoidemia via adaptations in the brain and adrenal glands in male Zucker diabetic fatty rats by Campbell, Jonathan E, Király, Michael A, Atkinson, Daniel J, D'souza, Anna M, Vranic, Mladen, Riddell, Michael C

“…We determined the effects of voluntary wheel running on the hypothalamic-pituitary-adrenal (HPA) axis, and the peripheral determinants of glucocorticoids…”
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Attenuation of type 2 diabetes mellitus in the male Zucker diabetic fatty rat: the effects of stress and non-volitional exercise by Király, Michael A, Bates, Holly E, Yue, Jessica T.Y, Goche-Montes, Danitza, Fediuc, Sergiu, Park, Edward, Matthews, Stephen G, Vranic, Mladen, Riddell, Michael C

“…Abstract To date, a limited number of studies have investigated the effects of exercise on the maintenance of endocrine pancreatic adaptations to worsening…”
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Changes in basal hypothalamo-pituitary-adrenal activity during exercise training are centrally mediated by Park, Edward, Chan, Owen, Li, Qifu, Kiraly, Mike, Matthews, Stephen G, Vranic, Mladen, Riddell, Michael C

“…The effects of exercise training on hypothalamo-pituitary-adrenal (HPA) function are unclear. We investigated whether pituitary-adrenal adaptation during…”
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Insulin Alone Increases Hypothalamo-Pituitary-Adrenal Activity, and Diabetes Lowers Peak Stress Responses by Chan, Owen, Inouye, Karen, Akirav, Eitan, Park, Edward, Riddell, Michael C, Vranic, Mladen, Matthews, Stephen G

“…Diabetes is associated with increased basal hypothalamo-pituitary-adrenal (HPA) activity and impaired stress responsiveness. Previously, we demonstrated that…”
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Molecular Regulation of the Hypothalamo-Pituitary-Adrenal Axis in Streptozotocin-Induced Diabetes: Effects of Insulin Treatment by Chan, Owen, Chan, Stephen, Inouye, Karen, Vranic, Mladen, Matthews, Stephen G

“…Increased hypothalamo-pituitary-adrenocortical (HPA) activity in diabetes is likely important in the development of some pathologies associated with the…”
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Diabetes Impairs Hypothalamo-Pituitary-Adrenal (HPA) Responses to Hypoglycemia, and Insulin Treatment Normalizes HPA but not Epinephrine Responses by CHAN, Owen, CHAN, Stephen, INOUYE, Karen, SHUM, Kathy, MATTHEWS, Stephen G, VRANIC, Mladen

“…Diabetes Impairs Hypothalamo-Pituitary-Adrenal (HPA) Responses to Hypoglycemia, and Insulin Treatment Normalizes HPA but not Epinephrine Responses Owen Chan 1…”
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Combined Infusion of Epinephrine and Norepinephrine During Moderate Exercise Reproduces the Glucoregulatory Response of Intense Exercise by KREISMAN, Stuart H, HALTER, Jeffrey B, VRANIC, Mladen, MARLISS, Errol B

“…Combined Infusion of Epinephrine and Norepinephrine During Moderate Exercise Reproduces the Glucoregulatory Response of Intense Exercise Stuart H. Kreisman 1 ,…”
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The Effect of Systemic Versus Portal Insulin Delivery in Pancreas Transplantation on Insulin Action and VLDL Metabolism by CARPENTIER, André, PATTERSON, Bruce W, UFFELMAN, Kristine D, GIACCA, Adria, VRANIC, Mladen, CATTRAL, Mark S, LEWIS, Gary F

“…The Effect of Systemic Versus Portal Insulin Delivery in Pancreas Transplantation on Insulin Action and VLDL Metabolism André Carpentier 1 , Bruce W. Patterson…”
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Hepatic glucose production is regulated both by direct hepatic and extrahepatic effects of insulin in humans by LEWIS, G. F, ZINMAN, B, GROENEWOUD, Y, VRANIC, M, GIACCA, A

“…The present study examines the effect of the route of insulin delivery on glucose turnover in humans. By using a new noninvasive in vivo method, the acute…”
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Intense Exercise Has Unique Effects on Both Insulin Release and Its Roles in Glucoregulation by Marliss, Errol B., Vranic, Mladen

“…Intense Exercise Has Unique Effects on Both Insulin Release and Its Roles in Glucoregulation Implications for Diabetes Errol B. Marliss 1 and Mladen Vranic 2 1…”
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Odyssey between Scylla and Charybdis through storms of carbohydrate metabolism and diabetes: a career retrospective by Vranic, Mladen

“…This research perspective allows me to summarize some of my work completed over 50 years, and it is organized in seven sections. 1) The treatment of diabetes…”
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Insulin induces the translocation of GLUT4 from a unique intracellular organelle to transverse tubules in rat skeletal muscle by MARETTE, A, BURDETT, E, DOUEN, A, VRANIC, M, KLIP, A

“…Skeletal muscle surface membrane is constituted by the PM domain and its specialized deep invaginations known as TTs. We have shown previously that insulin…”
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Estimation of endogenous glucose production during hyperinsulinemic-euglycemic glucose clamps: comparison of unlabeled and labeled exogenous glucose infusates by FINEGOOD, D. T, BERGMAN, R. N, VRANIC, M

“…Tracer methodology has been applied extensively to the estimation of endogenous glucose production (Ra) during euglycemic glucose clamps. The accuracy of this…”
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Epinephrine infusion during moderate intensity exercise increases glucose production and uptake by Kreisman, S H, Ah Mew, N, Arsenault, M, Nessim, S J, Halter, J B, Vranic, M, Marliss, E B

“…The glucoregulatory response to intense exercise [IE, >80% maximum O(2) uptake (VO(2 max))] comprises a marked increment in glucose production (R(a)) and a…”
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Oleanolic acid enhances insulin secretion in pancreatic β-cells by Teodoro, Tracy, Zhang, Liling, Alexander, Todd, Yue, Jessica, Vranic, Mladen, Volchuk, Allen

“…We investigated the effect of oleanolic acid, a plant-derived triterpenoid, on insulin secretion and content in pancreatic β-cells and rat islets. Oleanolic…”
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Intense exercise has unique effects on both insulin release and its roles in glucoregulation: Implications for diabetes by MARLISS, Errol B, VRANIC, Mladen

“…In intense exercise (>80% VO(2max)), unlike at lesser intensities, glucose is the exclusive muscle fuel. It must be mobilized from muscle and liver glycogen in…”
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Muscle, liver, and pancreas: Three Musketeers fighting to control glycemia by Klip, Amira, Vranic, Mladen

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