Search Results - "Vrána, O"

Comment on "Delivering a photosensitive transplatin prodrug to overcome cisplatin drug resistance" by H. Song, W. Li, R. Qi, L. Yan, X. Jing, M. Zheng and H. Xiao, Chem. Commun., 2015, 51, 11493 by Brabec, V, Vrana, O, Novakova, O, Kasparkova, J

“…Consistency of literature results with the transformation of trans-diamminedichloridoplatinum(ii) (transplatin) into cis-diammine-dichloridoplatinum(ii)…”
Get more information

DNA Modifications by a Novel Bifunctional Trinuclear Platinum Phase I Anticancer Agent by Brabec, Viktor, Kašpárková, Jana, Vrána, Oldøich, Nováková, Olga, Cox, John W, Qu, Yun, Farrell, Nicholas

“…The DNA-binding profile of a novel, trinuclear platinum Phase I clinical agent (BBR3464) is summarized. The structure of BBR3464 is best described as two…”
Get full text

Superhelical Torsion Controls DNA Interstrand Cross-Linking by Antitumor Cis- Diamminedichloroplatinum(II) by Vrâna, Oldrich, Boudny, Vladimir, Brabec, Viktor

“…Negatively supercoiled, relaxed and linearized forms of pSP73 DNA were modified in cell-free medium by cis-diamminedichloroplatinum(II) (cisplatin). The…”
Get full text

Correlation between Cytotoxicity and DNA Binding of Polypyridyl Ruthenium Complexes by Novakova, Olga, Kasparkova, Jana, Vrana, Oldrich, van Vliet, Paul M, Reedijk, Jan, Brabec, Viktor

“…The cytotoxicity of chloropolypyridyl ruthenium complexes of structural formulas [Ru(terpy)-(bpy)Cl]Cl, cis-[Ru(bpy)2Cl2], and mer-[Ru(terpy)Cl3] (terpy =…”
Get full text

Effect of Geometric Isomerism in Dinuclear Platinum Antitumor Complexes on DNA Interstrand Cross-Linking by Kašpárková, Jana, Nováková, Olga, Vrána, Oldřich, Farrell, Nicholas, Brabec, Viktor

“…The requirement for novel platinum antitumor drugs led to the synthesis of dinuclear bisplatinum complexes. To understand the molecular mechanisms underlying…”
Get full text

DNA Adducts of Antitumor Trans-[PtCl2 (E-Imino Ether)2] by Brabec, Viktor, Vrána, Oldrich, Nováková, Olga, Kleinwächter, Vladimír, Intini, Francesco P., Coluccia, Mauro, Natile, Giovanni

“…It has been shown recently that some analogues of clinically ineffective trans-diamminedichloroplatinum(II) (transplatin) exhibit antitumor activity. This…”
Get full text

The effect of combined treatment with platinum complexes and ionizing radiation on DNA in vitro by Vrána, O, Brabec, V

“…The conformation of isolated calf-thymus DNA treated with cis-diamminedichloroplatinum(II) (cis-DDP) or its trans-isomer (trans-DDP) and gamma radiation in…”
Get more information

Biophysical studies of the complexes of polyriboguanylic acid with brominated and chlorinated polyribocytidylic acids by Kogan, E M, Dyatlova, N G, Sidorova, N S, Vilner, L M, Vrána, O, Brabec, V

“…Conformation of double-stranded complexes of polyriboguanylic acid with halogenated polyribocytidylic acid [poly(C)] was studied with the aid of differential…”
Get more information

Polarographic activity of the antitumor drug cis-dichlorodiammineplatinum (II). The effect of hydrolysis and trans-isomerization of the drug by Vrána, O, Kleinwächter, V, Brabec, V

“…Electrochemical activities of cis-dichlorodiammineplatinum (II) (cis-DDP) and its trans isomer were studied by classical and differential pulse polarography…”
Get full text

DNA modifications by antitumor trans-[PtCl2(E-iminoether)2] by Zaludová, R, Zákovská, A, Kaspárkova, J, Balcarová, Z, Vrána, O, Coluccia, M, Natile, G, Brabec, V

“…Recent findings that an analogue of clinically ineffective transplatin, trans-[PtCl2(E-iminoether)2], exhibits antitumor activity has helped reevaluation of…”
Get more information

DNA interactions of new antitumor aminophosphine platinum(II) complexes by Neplechová, K, Kaspárková, J, Vrána, O, Nováková, O, Habtemariam, A, Watchman, B, Sadler, P J, Brabec, V

“…Mechanistic studies are presented of a novel class of aminophosphine platinum(II) complexes as potential anticancer agents. These new agents, which have…”
Get more information

DNA Interactions of Bifunctional Dinuclear Platinum(II) Antitumor Agents by Žaludová, Renata, Žákovská, Alena, Kašpárková, Jana, Balcarová, Zdenka, Kleinwächter, Vladimír, Vrana, Oldřich, Farrell, Nicholas, Brabec, Viktor

“…Modifications of natural DNA in a cell‐free medium by dinuclear bisplatinum complexes with equivalent coordination spheres, represented by the general formula…”
Get full text

DNA Interactions of Monofunctional Organometallic Ruthenium(II) Antitumor Complexes in Cell-free Media by Novakova, Olga, Chen, Haimei, Vrana, Oldrich, Rodger, Alison, Sadler, Peter J, Brabec, Viktor

“…Modifications of natural DNA in a cell-free medium by antitumor monodentate Ru(II) arene compounds of the general formula [(η6-arene)Ru(en)Cl]+ (arene =…”
Get full text

Biophysical analysis of DNA modified by 1,2-diaminocyclohexane platinum(II) complexes by Boudný, Vladimir, Vrána, Oldrich, Gaucheron, Frederic, Kleinwachter, Vladimir, Leng, Marc, Brabec, Viktor

“…Modification of DNA and double-stranded deoxyoligonucleotides with antitumour 1, 2-diamino-cyclohexanedinitroplatinum(II) (Pt-dach) complexes was investigated…”
Get full text

DNA interactions of antitumor platinum(IV) complexes by Nováková, O, Vrána, O, Kiseleva, V I, Brabec, V

“…Modifications of natural DNA and synthetic double-stranded oligodeoxyribonucleotides by cis-diamminedichloro-trans-dihydroxyplatinum(IV) (oxoplatin) were…”
Get full text

Polarographic studies on the conformation of some platinum complexes: relations to anti-tumour activity by Vrána, O, Brabec, V, Kleinwächter, V

“…Conformational alterations induced in DNA by the binding of various bivalent and tetravalent platinum complexes were characterized by means of differential…”
Get more information

Mechanistic studies of the modulation of cleavage activity of topoisomerase I by DNA adducts of mono- and bi-functional PtII complexes by Malina, Jaroslav, Vrana, Oldrich, Brabec, Viktor

“…Using electrophoresis and replication mapping, we show that the presence of DNA adducts of bifunctional antitumor cisplatin or monodentate [PtCl(dien)]Cl (dien…”
Get full text

Effect of the geometry of the central coordination sphere in antitumor trinuclear platinum complexes on DNA binding by Kasparkova, Jana, Vrana, Oldrich, Farrell, Nicholas, Brabec, Viktor

“…Polynuclear platinum compounds comprise a unique class of anticancer agents with chemical and biological properties different from mononuclear platinum drugs…”
Get full text

l-Methionine Inhibits Reaction of DNA with Anticancer cis-Diamminedichloroplatinum(II) by Vrana, Oldrich, Brabec, Viktor

“…Sufficient evidence has accumulated to identify DNA as the relevant pharmacological target of antitumor cisplatin [cis-diamminedichloroplatinum(II)]. This drug…”
Get full text

Platinum determination in cis-dichlorodiammineplatinum(II)--DNA complexes by differential pulse polarography by Vrána, O, Brabec, V

“…A simple polarographic assay for platinum determination in cis-dichlorodiammineplatinum(II)-DNA complexes is described. The method makes it possible to…”
Get more information