Search Results - "Vrábel, M."
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ELVES Measurements in the “UV Atmosphere” (Mini-EUSO) Experiment Onboard the ISS and Their Reconstruction
Published in Cosmic research (2024)“…More than three dozen submillisecond events of ELVES type (“elves”), which are the result of the interaction of the front of an electromagnetic pulse from a…”
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Developments and results in the context of the JEM-EUSO program obtained with the ESAF simulation and analysis framework
Published in The European physical journal. C, Particles and fields (01-11-2023)“…JEM-EUSO is an international program for the development of space-based Ultra-High Energy Cosmic Ray observatories. The program consists of a series of…”
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An end-to-end calibration of the Mini-EUSO detector in space
Published in Astroparticle physics (01-02-2025)“…Mini-EUSO is a wide Field-of-View (44∘×44∘) telescope currently in operation from a nadir-facing Ultra-Violet (UV) transparent window in the Russian Zvezda…”
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Detection limits and trigger rates for ultra-high energy cosmic ray detection with the EUSO-TA ground-based fluorescence telescope
Published in Astroparticle physics (01-11-2024)“…EUSO-TA is a ground-based fluorescence telescope built to validate the design of ultra-high energy cosmic ray fluorescence detectors to be operated in space…”
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The transcription factor GLI1 mediates TGFβ1 driven EMT in hepatocellular carcinoma via a SNAI1-dependent mechanism
Published in PloS one (19-11-2012)“…The role of the epithelial-to-mesenchymal transition (EMT) during hepatocellular carcinoma (HCC) progression is well established, however the regulatory…”
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GLI1 Inhibition Promotes Epithelial-to-Mesenchymal Transition in Pancreatic Cancer Cells
Published in Cancer research (Chicago, Ill.) (01-01-2012)“…The Hedgehog (HH) pathway has been identified as an important deregulated signal transduction pathway in pancreatic ductal adenocarcinoma (PDAC), a cancer type…”
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Integration, qualification, and launch of the Mini-EUSO telescope on board the ISS
Published in Atti della Accademia nazionale dei Lincei. Rendiconti Lincei. Scienze fisiche e naturali (2023)“…Mini-EUSO is a high-sensitivity imaging telescope that observes the Earth from the ISS in the near ultraviolet band (290 ÷ 430 nm), through the nadir-facing,…”
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Cloud distribution evaluated by the WRF model during the EUSO-SPB1 flight
Published in EPJ Web of conferences (2019)“…EUSO-SPB1 was a balloon-borne mission of the JEM-EUSO (Joint Experiment Missions for Extreme Universe Space Observatory) Program aiming at the ultra-high…”
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Primary Trabecular Meshwork Cells Incubated in Human Aqueous Humor Differ from Cells Incubated in Serum Supplements
Published in Investigative ophthalmology & visual science (01-08-2005)“…To determine whether aqueous humor, the in vivo source of nutrients for trabecular meshwork cells, alters cellular and molecular characteristics in primary…”
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GLI1 interaction with p300 modulates SDF1 expression in cancer-associated fibroblasts to promote pancreatic cancer cells migration
Published in Biochemical journal (15-02-2023)“…Carcinoma-associated fibroblasts (CAFs) play an important role in the progression of multiple malignancies. Secretion of cytokines and growth factors underlies…”
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M. Vrabel and T. Carell for Cycloadditions in Bioorthogonal Chemistry
Published in Topics in current chemistry (2016) (01-04-2016)Get full text
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The transcription factor GLI1 cooperates with the chromatin remodeler SMARCA2 to regulate chromatin accessibility at distal DNA regulatory elements
Published in The Journal of biological chemistry (26-06-2020)“…The transcription factor GLI1 (GLI family zinc finger 1) plays a key role in the development and progression of multiple malignancies. To date, regulation of…”
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Erratum to: M. Vrabel and T. Carell for Cycloadditions in Bioorthogonal Chemistry
Published in Topics in current chemistry (2016) (13-04-2016)Get full text
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The identification of myocilin-associated proteins in the human trabecular meshwork
Published in Experimental eye research (01-06-2006)“…Myocilin forms high molecular weight complexes in vivo presumably due to interaction with itself and other myocilin binding proteins. To identify myocilin…”
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Perfusion of His-Tagged Eukaryotic Myocilin Increases Outflow Resistance in Human Anterior Segments in the Presence of Aqueous Humor
Published in Investigative ophthalmology & visual science (01-01-2006)“…A previous study by the authors has shown that recombinant myocilin purified from a prokaryotic expression system increases outflow resistance in cultured…”
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A rare germline CDKN2A variant (47T>G; p16-L16R) predisposes carriers to pancreatic cancer by reducing cell cycle inhibition
Published in The Journal of biological chemistry (01-01-2021)“…Germline mutations in CDKN2A, encoding the tumor suppressor p16, are responsible for a large proportion of familial melanoma cases and also increase risk of…”
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In vitro and in vivo characterization of disulfide bond use in myocilin complex formation
Published in Molecular vision (27-06-2004)“…Myocilin forms large complexes in aqueous humor. Part of this complex formation is due to myocilin-myocilin protein non-covalent interactions within the…”
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Modulation of the IL-6 Receptor α Underlies GLI2-Mediated Regulation of Ig Secretion in Waldenström Macroglobulinemia Cells
Published in The Journal of immunology (1950) (15-09-2015)“…Ig secretion by terminally differentiated B cells is an important component of the immune response to foreign pathogens. Its overproduction is a defining…”
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Evaluating the parent-of-origin effect in bipolar affective disorder: Is a more penetrant subtype transmitted paternally?
Published in Journal of affective disorders (01-09-2000)“…Background: Numerous genetic mechanisms and modes of transmission underlying bipolar affective disorder (BPAD) have been postulated. Recently, the discovery of…”
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Myocilin Levels in Primary Open-angle Glaucoma and Pseudoexfoliation Glaucoma Human Aqueous Humor
Published in Journal of glaucoma (01-12-2010)“…PURPOSETo determine the concentration of myocilin in primary open-angle glaucoma (POAG) and pseudoexfoliation glaucoma (PEXG) aqueous humor. METHODSAqueous…”
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