Search Results - "Voziyan, P."

Pyridoxamine as a multifunctional pharmaceutical: targeting pathogenic glycation and oxidative damage by Voziyan, P A, Hudson, B G

“…The discovery that pyridoxamine (PM) can inhibit glycation reactions and the formation of advanced glycation end products (AGEs) stimulated new interest in…”
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Cellular oxidative stress response mediates radiosensitivity in Fus1-deficient mice by Yazlovitskaya, E M, Voziyan, P A, Manavalan, T, Yarbrough, W G, Ivanova, A V

“…Mechanism of radiosensitivity of normal tissues, a key factor in determining the toxic side effects of cancer radiotherapy, is not fully understood. We…”
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A novel radioprotective function for the mitochondrial tumor suppressor protein Fus1 by Yazlovitskaya, E M, Uzhachenko, R, Voziyan, P A, Yarbrough, W G, Ivanova, A V

“…FUS1/TUSC2 is a mitochondrial tumor suppressor with activity to regulate cellular oxidative stress by maintaining balanced ROS production and mitochondrial…”
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Glomerular injury is exacerbated in diabetic integrin α1-null mice by Zent, R., Yan, X., Su, Y., Hudson, B.G., Borza, D.-B., Moeckel, G.W., Qi, Z., Sado, Y., Breyer, M.D., Voziyan, P., Pozzi, A.

“…Excessive glomerular collagen IV and reactive oxygen species (ROS) production are key factors in the development of diabetic nephropathy. Integrin α1β1, the…”
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Modification of proteins in vitro by physiological levels of glucose: pyridoxamine inhibits conversion of Amadori intermediate to advanced glycation end-products through binding of redox metal ions by Voziyan, Paul A, Khalifah, Raja G, Thibaudeau, Christophe, Yildiz, Alaattin, Jacob, Jaison, Serianni, Anthony S, Hudson, Billy G

“…Hyperglycemic conditions of diabetes accelerate protein modifications by glucose leading to the accumulation of advanced glycation end-products (AGEs). We have…”
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Chaperonin-assisted folding of glutamine synthetase under nonpermissive conditions: Off-pathway aggregation propensity does not determine the co-chaperonin requirement by VOZIYAN, PAUL A., FISHER, MARK T.

“…One of the proposed roles of the GroEL-GroES cavity is to provide an “infinite dilution” folding chamber where protein substrate can fold avoiding deleterious…”
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Mechanism of Farnesol Cytotoxicity: Further Evidence for the Role of PKC-Dependent Signal Transduction in Farnesol-Induced Apoptotic Cell Death by Voziyan, P.A., Haug, J.S., Melnykovych, G.

“…Mechanism of the inhibitory effect of isoprenoid farnesol on cell proliferation has been studied in human acute leukemia CEM-C1 cells. Farnesol (20μM) reduced…”
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Amadori-Lysyl-Induced Propagation of Protein Modifications Is Inhibited by Pyridoxamine by VOZIYAN, P A, CHETYRKIN, S V, HUDSON, B G

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Farnesol inhibits phosphatidylcholine biosynthesis in cultured cells by decreasing cholinephosphotransferase activity by Voziyan, P A, Goldner, C M, Melnykovych, G

“…The mechanism of inhibition of phosphatidylcholine (PC) biosynthesis by the isoprenoid farnesol was investigated in the human leukaemic CEM-C1 cell line. Cells…”
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312 ROLE OF METHYLGLYOXAL IN THE PATHOGENESIS OF DIABETIC NEPHROPATHY by Chuang, P., Saleem, M. A., Mathieson, P. W., Hudson, B. G., Voziyan, P. A.

“…Diabetic nephropathy (DN) is the leading cause of end-stage renal disease in the United States. Why DN develops in up to 40% of diabetic patients is currently…”
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Molecular Architecture of the Goodpasture Autoantigen in Anti-GBM Nephritis by Pedchenko, Vadim, Bondar, Olga, Fogo, Agnes B, Vanacore, Roberto, Voziyan, Paul, Kitching, A. Richard, Wieslander, Jörgen, Kashtan, Clifford, Borza, Dorin-Bogdan, Neilson, Eric G, Wilson, Curtis B, Hudson, Billy G

“…This study compared the conformation of the antibody epitopes in Goodpasture's disease and Alport's post-transplantation nephritis in search of the…”
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Differences in sensitivity to farnesol toxicity between neoplastically- and non-neoplastically-derived cells in culture by Adany, I, Yazlovitskaya, E M, Haug, J S, Voziyan, P A, Melnykovych, G

“…Six neoplastically-derived cell lines and three cell lines derived from normal tissues were compared for their sensitivity to isoprenoid trans-trans farnesol…”
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Refolding a glutamine synthetase truncation mutant in vitro: identifying superior conditions using a combination of chaperonins and osmolytes by Voziyan, P A, Jadhav, L, Fisher, M T

“…A new method that uses a combination of bacterial GroE chaperonins and cellular osmolytes for in vitro protein folding is described. With this method, one can…”
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Directed cell killing (apoptosis) in human lymphoblastoid cells incubated in the presence of farnesol: effect of phosphatidylcholine by Haug, J S, Goldner, C M, Yazlovitskaya, E M, Voziyan, P A, Melnykovych, G

“…Previously reported observations have shown that trans-trans farnesol inhibits incorporation of choline into phosphatidylcholine and reduces the growth rate of…”
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Partitioning of rhodanese onto GroEL. Chaperonin binds a reversibly oxidized form derived from the native protein by Smith, K E, Voziyan, P A, Fisher, M T

“…The mammalian mitochondrial enzyme, rhodanese, can form stable complexes with the Escherichia coli chaperonin GroEL if it is either refolded from 8 M urea in…”
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Truncations of the C-Terminus Have Different Effects on the Conformation and Activity of Phosphatidylinositol Transfer Protein by Voziyan, Paul A, Tremblay, Jacqueline M, Yarbrough, Lynwood R, Helmkamp, George M

“…Contributions of the C-terminus toward the conformation and activity of phosphatidylinositol transfer protein (PITP) were studied by comparing properties of…”
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Changing the Nature of the Initial Chaperonin Capture Complex Influences the Substrate Folding Efficiency by Voziyan, Paul A., Tieman, Bryan C., Low, Chee-Meng, Fisher, Mark T.

“…For the chaperonin substrates, rhodanese, malate dehydrogenase (MDH), and glutamine synthetase (GS), the folding efficiencies, and the lifetimes of folding…”
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Importance of Phospholipid in the Folding and Conformation of Phosphatidylinositol Transfer Protein:  Comparison of Apo and Holo Species by Voziyan, Paul A, Tremblay, Jacqueline M, Yarbrough, Lynwood R, Helmkamp, George M

“…The significance of noncovalently bound phospholipid as a structural component of phosphatidylinositol transfer protein (PITP) and its role in acquisition and…”
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The C-terminus of phosphatidylinositol transfer protein modulates membrane interactions and transfer activity but not phospholipid binding by Tremblay, J M, Voziyan, P A, Helmkamp, Jr, G M, Yarbrough, L R

“…Rat phosphatidylinositol transfer protein (PITP) is a 32 kDa protein containing 271 amino acids. It is involved in a number of cell functions including…”
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Glomerular injury is exacerbated in diabetic integrin 1-null mice by Zent, R, Yan, X, Y Su, Hudson, B G, D-B Borza, Moeckel, G W, Z Qi, Sado, Y, Breyer, M D, Voziyan, P, Pozzi, A

“…Excessive glomerular collagen IV and reactive oxygen species (ROS) production are key factors in the development of diabetic nephropathy. Integrin alpha1beta1,…”
Get full text