Search Results - "Votta, B J"

Peptide Aldehyde Inhibitors of Cathepsin K Inhibit Bone Resorption Both In Vitro and In Vivo by Votta, Bartholomew J., Levy, Mark A., Badger, Alison, Bradbeer, Jeremy, Dodds, Robert A., James, Ian E., Thompson, Scott, Bossard, Mary J., Carr, Thomas, Connor, Janice R., Tomaszek, Thaddeus A., Szewczuk, Lawrence, Drake, Fred H., Veber, Daniel F., Gowen, Maxine

“…We have shown previously that cathepsin K, a recently identified member of the papain superfamily of cysteine proteases, is expressed selectively in…”
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Inhibition of p38 MAP kinase as a therapeutic strategy by Lee, John C, Kumar, Sanjay, Griswold, Don E, Underwood, David C, Votta, Bartholomew J, Adams, Jerry L

“…Since the discovery of p38 MAP kinase in 1994, our understanding of its biology has progressed dramatically. The key advances include (1) identification of p38…”
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Cytokine suppressive anti-inflammatory compounds inhibit bone resorption in vitro by Votta, B J, Bertolini, D R

“…Data from several laboratories suggest a role for a variety of cytokines in the process of bone resorption. SK&F 86002…”
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Interleukin-1 inhibits osmotically induced calcium signaling and volume regulation in articular chondrocytes by Pritchard, S., Ph.D, Votta, B.J., M.S, Kumar, S., Ph.D, Guilak, F., Ph.D

“…Summary Objective Articular chondrocytes respond to osmotic stress with transient changes in cell volume and the intracellular concentration of calcium ion…”
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Antagonizing the parathyroid calcium receptor stimulates parathyroid hormone secretion and bone formation in osteopenic rats by Gowen, M, Stroup, G B, Dodds, R A, James, I E, Votta, B J, Smith, B R, Bhatnagar, P K, Lago, A M, Callahan, J F, DelMar, E G, Miller, M A, Nemeth, E F, Fox, J

“…Parathyroid hormone (PTH) is an effective bone anabolic agent, but it must be administered parenterally. An orally active anabolic agent would provide a…”
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IL-1- and TNF-induced bone resorption is mediated by p38 mitogen activated protein kinase by Kumar, Sanjay, Votta, Bartholomew J., Rieman, David J., Badger, Alison M., Gowen, Maxine, Lee, John C.

“…We have previously shown that p38 mitogen‐activated protein kinase (MAPK) inhibitors, which block the production and action of inflammatory cytokines such as…”
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Identification and Cloning of a Connective Tissue Growth Factor-like cDNA from Human Osteoblasts Encoding a Novel Regulator of Osteoblast Functions by Kumar, S, Hand, A T, Connor, J R, Dodds, R A, Ryan, P J, Trill, J J, Fisher, S M, Nuttall, M E, Lipshutz, D B, Zou, C, Hwang, S M, Votta, B J, James, I E, Rieman, D J, Gowen, M, Lee, J C

“…We have identified and cloned a novel connective tissue growth factor-like (CTGF-L) cDNA from primary human osteoblast cells encoding a 250-amino acid single…”
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Effect of auranofin treatment on aberrant splenic interleukin production in adjuvant arthritic rats by Lee, JC, Dimartino, MJ, Votta, BJ, Hanna, N

“…Adjuvant-induced arthritis (AA) in rats is associated with a number of immunologic abnormalities which include a marked decrease in spleen cell mitogenic…”
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Macrophage activation in rat models of inflammation and arthritis. Systemic activation precedes arthritis induction and progression by Johnson, W J, Muirhead, K A, Meunier, P C, Votta, B J, Schmitt, T C, DiMartino, M J, Hanna, N

“…The association between the induction and progression of adjuvant-induced arthritis (AA) and the development of synovial and systemic macrophage activation was…”
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OR3-001 – RIP2 kinase is activated in Blau Syndrome and IBD by Foley, KP, Desai, B, Vossenkämper, A, Reilly, MA, Biancheri, P, Wang, L, Lipshutz, DB, Connor, J, Miller, M, Haile, PA, Casillas, LN, Votta, BJ, Gough, PJ, MacDonald, TT, Wouters, CH, Rosé, CD, Bertin, J

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CKbeta-8 [CCL23], a novel CC chemokine, is chemotactic for human osteoclast precursors and is expressed in bone tissues by Votta, B J, White, J R, Dodds, R A, James, I E, Connor, J R, Lee-Rykaczewski, E, Eichman, C F, Kumar, S, Lark, M W, Gowen, M

“…We have previously demonstrated that a tartrate-resistant acid phosphatase (TRAP)-positive subpopulation of mononuclear cells isolated from collagenase digests…”
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A New Dimeric Dihydrochalcone and a New Prenylated Flavone from the Bud Covers of Artocarpus altilis:  Potent Inhibitors of Cathepsin K by PATIL, Ashok D., FREYER, Alan J., KILLMER, Lew, OFFEN, Priscilla, TAYLOR, Paul B., VOTTA, Bartholomew J., JOHNSON, Randall K.

“…A MeOH/CH(2)Cl(2) extract of the bud covers of Artocarpus altilis collected in Micronesia showed activity in a cathepsin K inhibition assay. In addition to the…”
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Inhibition of p38 MAP kinase as a therapeutic strategy: A Collection of Reviews on Immunosuppressive Drugs by LEE, J. C, KUMAR, S, GRISWOLD, D. E, UNDERWOOD, D. C, VOTTA, B. J, ADAMS, J. L

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