Search Results - "Vosshenrich, Christian A.J"

Transcriptional regulation of innate lymphoid cell fate by Serafini, Nicolas, Vosshenrich, Christian A. J., Di Santo, James P.

“…Key Points Three distinct groups of innate lymphoid cells (ILCs) have been categorized — these have unique and overlapping functions in immunity. Several…”
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IL-7 and IL-15 independently program the differentiation of intestinal CD3-NKp46+ cell subsets from Id2-dependent precursors by Satoh-Takayama, Naoko, Lesjean-Pottier, Sarah, Vieira, Paulo, Sawa, Shinichiro, Eberl, Gerard, Vosshenrich, Christian A J, Di Santo, James P

“…The natural cytotoxicity receptor NKp46 (encoded by Ncr1) was recently shown to identify a subset of noncytotoxic, Rag-independent gut lymphocytes that express…”
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IL‐1β regulates a novel myeloid‐derived suppressor cell subset that impairs NK cell development and function by Elkabets, Moshe, Ribeiro, Vera S.G, Dinarello, Charles A, Ostrand‐Rosenberg, Suzanne, Di Santo, James P, Apte, Ron N, Vosshenrich, Christian A.J

“…Chronic inflammation is associated with promotion of malignancy and tumor progression. Many tumors enhance the accumulation of myeloid‐derived suppressor cells…”
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GATA-3 Promotes Maturation, IFN-γ Production, and Liver-Specific Homing of NK Cells by Samson, Sandrine I, Richard, Odile, Tavian, Manuela, Ranson, Thomas, Vosshenrich, Christian A.J, Colucci, Francesco, Buer, Jan, Grosveld, Frank, Godin, Isabelle, Di Santo, James P

“…The GATA-3 transcription factor has a determinant role in T cell specification and is an essential mediator of T helper 2-type polarized immune responses…”
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Lymphotoxin-β receptor-independent development of intestinal IL-22-producing NKp46⁺ innate lymphoid cells by Satoh-Takayama, Naoko, Lesjean-Pottier, Sarah, Sawa, Shinichiro, Vosshenrich, Christian A.J, Eberl, Gérard, Di Santo, James P

“…The natural cytotoxicity receptor NKp46 is an activating receptor expressed by several distinct innate lymphoid cell (ILC) subsets, including NK cells, some γδ…”
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intrathymic crossroads of T and NK cell differentiation by Klein Wolterink, Roel G.J, García‐Ojeda, Marcos E, Vosshenrich, Christian A.J, Hendriks, Rudi W, Di Santo, James P

“…T lymphocytes depend on the thymic microenvironment for initiation of the T‐cell developmental program. As the progenitors in the thymus have lost the capacity…”
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Cytokines: IL-21 joins the γc-dependent network? by Voßhenrich, Christian A.J, Di Santo, James P

“…The discovery of the cytokine IL-21 adds another member to the ever-growing list of small secreted molecules that have potent effects on lymphoid cells…”
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Interleukin signaling by Voßhenrich, Christian A.J, Di Santo, James P

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CD11cloB220+ interferon-producing killer dendritic cells are activated natural killer cells by Vosshenrich, Christian A J, Lesjean-Pottier, Sarah, Hasan, Milena, Richard-Le Goff, Odile, Corcuff, Erwan, Mandelboim, Ofer, Di Santo, James P

“…Interferon-producing killer dendritic cells (IKDCs) are a recently described subset of CD11c(lo)B220(+) cells that share phenotypic and functional properties…”
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Gata3 drives development of RORγt+ group 3 innate lymphoid cells by Serafini, Nicolas, Klein Wolterink, Roel G J, Satoh-Takayama, Naoko, Xu, Wei, Vosshenrich, Christian A J, Hendriks, Rudi W, Di Santo, James P

“…Group 3 innate lymphoid cells (ILC3) include IL-22-producing NKp46(+) cells and IL-17A/IL-22-producing CD4(+) lymphoid tissue inducerlike cells that express…”
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Microbial Flora Drives Interleukin 22 Production in Intestinal NKp46 + Cells that Provide Innate Mucosal Immune Defense by Satoh-Takayama, Naoko, Vosshenrich, Christian A.J., Lesjean-Pottier, Sarah, Sawa, Shinichiro, Lochner, Matthias, Rattis, Frederique, Mention, Jean-Jacques, Thiam, Kader, Cerf-Bensussan, Nadine, Mandelboim, Ofer, Eberl, Gerard, Di Santo, James P.

“…Natural killer (NK) cells are innate lymphocytes with spontaneous antitumor activity, and they produce interferon-γ (IFN-γ) that primes immune responses…”
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Developmental pathways that generate natural-killer-cell diversity in mice and humans by Di Santo, James P, Huntington, Nicholas D, Vosshenrich, Christian A. J

“…Natural killer (NK) cells are large granular lymphocytes capable of producing inflammatory cytokines and spontaneously killing malignant, infected or…”
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Developmental programming of natural killer and innate lymphoid cells by Vosshenrich, Christian AJ, Di Santo, James P

“…Highlights ► ILCs include NK cells, nuocytes/NH cells, LTi cells and NKp46+ IL-22+ cells. ► ILC rapidly produce cytokines (IL-5, -13, -17A, -22, IFN-g)…”
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Essential, dose-dependent role for the transcription factor Gata3 in the development of IL-5⁺ and IL-13⁺ type 2 innate lymphoid cells by Wolterink, Roel G. J. Klein, Serafini, Nicolas, van Nimwegen, Menno, Vosshenrich, Christian A. J., de Bruijn, Marjolein J. W., Pereira, Diogo Fonseca, Fernandes, Henrique Veiga, Hendriks, Rudi W., Di Santo, James P.

“…Group 2 innate lymphoid cells (ILC2s; also called nuocytes, innate helper cells, or natural helper cells) provide protective immunity during helminth infection…”
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Notch signaling in group 3 innate lymphoid cells modulates their plasticity by Chea, Sylvestre, Perchet, Thibaut, Petit, Maxime, Verrier, Thomas, Guy-Grand, Delphine, Banchi, Elena-Gaia, Vosshenrich, Christian A J, Di Santo, James P, Cumano, Ana, Golub, Rachel

“…The Notch signaling pathway is conserved throughout evolution, and it controls various processes, including cell fate determination, differentiation, and…”
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Host genetic control of natural killer cell diversity revealed in the Collaborative Cross by Dupont, Magali S. J., Guillemot, Vincent, Campagne, Pascal, Serafini, Nicolas, Marie, Solenne, Montagutelli, Xavier, Di Santo, James P., Vosshenrich, Christian A. J.

“…Natural killer (NK) cells are innate effectors armed with cytotoxic and cytokine-secreting capacities whose spontaneous antitumor activity is key to numerous…”
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Divergent roles for STAT4 in shaping differentiation of cytotoxic ILC1 and NK cells during gut inflammation by Scarno, Gianluca, Mazej, Julija, Laffranchi, Mattia, Di Censo, Chiara, Mattiola, Irene, Candelotti, Arianna M, Pietropaolo, Giuseppe, Stabile, Helena, Fionda, Cinzia, Peruzzi, Giovanna, Brooks, Stephen R, Tsai, Wanxia Li, Mikami, Yohei, Bernardini, Giovanni, Gismondi, Angela, Sozzani, Silvano, Di Santo, James P, Vosshenrich, Christian A J, Diefenbach, Andreas, Gadina, Massimo, Santoni, Angela, Sciumè, Giuseppe

“…Natural killer (NK) cells and type 1 innate lymphoid cells (ILC1) require signal transducer and activator of transcription 4 (STAT4) to elicit rapid effector…”
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A novel immunoregulatory role for NK-cell cytotoxicity in protection from HLH-like immunopathology in mice by Sepulveda, Fernando E., Maschalidi, Sophia, Vosshenrich, ChristianA.J., Garrigue, Alexandrine, Kurowska, Mathieu, Ménasche, Gael, Fischer, Alain, Di Santo, James P., de Saint Basile, Geneviève

“…The impairment of cytotoxic activity of lymphocytes disturbs immune surveillance and leads to the development of hemophagocytic lymphohistiocytic syndrome…”
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Phenotypic and Functional Plasticity of Murine Intestinal NKp46+ Group 3 Innate Lymphoid Cells by Verrier, Thomas, Satoh-Takayama, Naoko, Serafini, Nicolas, Marie, Solenne, Di Santo, James P, Vosshenrich, Christian A J

“…Group 3 innate lymphoid cells (ILC3) actively participate in mucosal defense and homeostasis through prompt secretion of IL-17A, IL-22, and IFN-γ. Reports…”
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A thymic pathway of mouse natural killer cell development characterized by expression of GATA-3 and CD127 by Ezine, Sophie, García-Ojeda, Marcos E, Pasqualetto, Valerie, Guy-Grand, Delphine, Di Santo, James P, Rocha, Benedita, Vosshenrich, Christian A J, Samson-Villéger, Sandrine I, Goff, Odile Richard-Le, Enault, Laurence, Cumano, Ana, Rogge, Lars, Corcuff, Erwan

“…Natural killer (NK) cell development is thought to occur in the bone marrow. Here we identify the transcription factor GATA-3 and CD127 (IL-7R alpha) as…”
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