Search Results - "Voss, Jan H."

Cell‐permeable high‐affinity tracers for Gq proteins provide structural insights, reveal distinct binding kinetics and identify small molecule inhibitors by Kuschak, Markus, Namasivayam, Vigneshwaran, Rafehi, Muhammad, Voss, Jan H., Garg, Jaspal, Schlegel, Jonathan G., Abdelrahman, Aliaa, Kehraus, Stefan, Reher, Raphael, Küppers, Jim, Sylvester, Katharina, Hinz, Sonja, Matthey, Michaela, Wenzel, Daniela, Fleischmann, Bernd K., Pfeifer, Alexander, Inoue, Asuka, Gütschow, Michael, König, Gabriele M., Müller, Christa E.

“…Background and Purpose G proteins are intracellular switches that transduce and amplify extracellular signals from GPCRs. The Gq protein subtypes, which are…”
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Irreversible Antagonists for the Adenosine A2B Receptor by Temirak, Ahmed, Schlegel, Jonathan G., Voss, Jan H., Vaaßen, Victoria J., Vielmuth, Christin, Claff, Tobias, Müller, Christa E.

“…Blockade of the adenosine A2B receptor (A2BAR) represents a potential novel strategy for the immunotherapy of cancer. In the present study, we designed,…”
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Imaging of Gα q Proteins in Mouse and Human Organs and Tissues by Voss, Jan H, Al-Hroub, Haneen, Gedschold, Robin, Dietrich, Jennifer M, Gaffal, Evelyn, Toma, Marieta, Kehraus, Stefan, König, Gabriele M, Brust, Peter, Fleischmann, Bernd K, Wenzel, Daniela, Deuther-Conrad, Winnie, Müller, Christa E

“…G protein-coupled receptors (GPCRs) transfer extracellular signals across cell membranes by activating intracellular heterotrimeric G proteins. Several studies…”
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Structure-affinity and structure-residence time relationships of macrocyclic Gαq protein inhibitors by Voss, Jan H., Crüsemann, Max, Bartling, Christian R.O., Kehraus, Stefan, Inoue, Asuka, König, Gabriele M., Strømgaard, Kristian, Müller, Christa E.

“…The macrocyclic depsipeptides YM-254890 (YM) and FR900359 (FR) are potent inhibitors of Gαq/11 proteins. They are important pharmacological tools and have…”
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Macrocyclic Gq Protein Inhibitors FR900359 and/or YM-254890–Fit for Translation? by Schlegel, Jonathan G, Tahoun, Mariam, Seidinger, Alexander, Voss, Jan H, Kuschak, Markus, Kehraus, Stefan, Schneider, Marion, Matthey, Michaela, Fleischmann, Bernd K, König, Gabriele M, Wenzel, Daniela, Müller, Christa E

“…Guanine nucleotide-binding proteins (G proteins) transduce extracellular signals received by G protein-coupled receptors (GPCRs) to intracellular signaling…”
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Crystal structure of adenosine A2A receptor in complex with clinical candidate Etrumadenant reveals unprecedented antagonist interaction by Claff, Tobias, Schlegel, Jonathan G., Voss, Jan H., Vaaßen, Victoria J., Weiße, Renato H., Cheng, Robert K. Y., Markovic-Mueller, Sandra, Bucher, Denis, Sträter, Norbert, Müller, Christa E.

“…The G s  protein-coupled adenosine A 2A receptor (A 2A AR) represents an emerging drug target for cancer immunotherapy. The clinical candidate Etrumadenant was…”
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Sensitive LC-MS/MS Method for the Quantification of Macrocyclic Gαq Protein Inhibitors in Biological Samples by Kuschak, Markus, Schlegel, Jonathan G., Schneider, Marion, Kehraus, Stefan, Voss, Jan H., Seidinger, Alexander, Matthey, Michaela, Wenzel, Daniela, Fleischmann, Bernd K., König, Gabriele M., Müller, Christa E.

“…The cyclic depsipeptide FR900359 (FR) isolated from the plant Ardisia crenata and produced by endosymbiotic bacteria acts as a selective Gq protein inhibitor…”
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Unraveling binding mechanism and kinetics of macrocyclic Gαq protein inhibitors by Voss, Jan H., Nagel, Jessica, Rafehi, Muhammad, Guixà-González, Ramon, Malfacini, Davide, Patt, Julian, Kehraus, Stefan, Inoue, Asuka, König, Gabriele M., Kostenis, Evi, Deupi, Xavier, Namasivayam, Vigneshwaran, Müller, Christa E.

“…G proteins represent intracellular switches that transduce signals relayed from G protein-coupled receptors. The structurally related macrocyclic depsipeptides…”
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Discovery of Anthranilic Acid Derivatives as Antagonists of the Pro-Inflammatory Orphan G Protein-Coupled Receptor GPR17 by Boshta, Nader M., Lewash, Michael, Köse, Meryem, Namasivayam, Vigneshwaran, Sarkar, Soumya, Voss, Jan H., Liedtke, Andy J., Junker, Anna, Tian, Maoqun, Stößel, Anne, Rashed, Mahmoud, Mahal, Ahmed, Merten, Nicole, Pegurier, Cécile, Hockemeyer, Jörg, Kostenis, Evi, Müller, Christa E.

“…The G protein-coupled receptor 17 (GPR17) is an orphan receptor involved in inflammatory diseases. GPR17 antagonists have been proposed for the treatment of…”
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Single Stabilizing Point Mutation Enables High‐Resolution Co‐Crystal Structures of the Adenosine A2A Receptor with Preladenant Conjugates by Claff, Tobias, Klapschinski, Tim A., Tiruttani Subhramanyam, Udaya K., Vaaßen, Victoria J., Schlegel, Jonathan G., Vielmuth, Christin, Voß, Jan H., Labahn, Jörg, Müller, Christa E.

“…The G protein‐coupled adenosine A2A receptor (A2AAR) is an important new (potential) drug target in immuno‐oncology, and for neurodegenerative diseases…”
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Single Stabilizing Point Mutation Enables High-Resolution Co-Crystal Structures of the Adenosine A 2A Receptor with Preladenant Conjugates by Claff, Tobias, Klapschinski, Tim A, Tiruttani Subhramanyam, Udaya K, Vaaßen, Victoria J, Schlegel, Jonathan G, Vielmuth, Christin, Voß, Jan H, Labahn, Jörg, Müller, Christa E

“…The G protein-coupled adenosine A receptor (A AR) is an important new (potential) drug target in immuno-oncology, and for neurodegenerative diseases…”
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Class-Wide Analysis of Frizzled-Dishevelled Interactions Using BRET Biosensors Reveals Functional Differences among Receptor Paralogs by Grätz, Lukas, Voss, Jan H., Schulte, Gunnar

“…Wingless/Int-1 (WNT) signaling is mediated by WNT binding to 10 Frizzleds (FZD1–10), which propagate the signal inside the cell by interacting with different…”
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Feature-Based Molecular Networking for the Targeted Identification of Gq‑Inhibiting FR900359 Derivatives by Hanke, Wiebke, Patt, Julian, Alenfelder, Judith, Voss, Jan H, Zdouc, Mitja M, Kehraus, Stefan, Kim, Jung Bong, Grujičić, Goran V, Namasivayam, Vigneshwaran, Reher, Raphael, Müller, Christa E, Kostenis, Evi, Crüsemann, Max, König, Gabriele M

“…Both the soil bacterium Chromobacterium vaccinii and the bacterial endosymbiont Candidatus Burkholderia crenata of the plant Ardisia crenata are producers of…”
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Cell-permeable high-affinity tracers for G q proteins provide structural insights, reveal distinct binding kinetics and identify small molecule inhibitors by Kuschak, Markus, Namasivayam, Vigneshwaran, Rafehi, Muhammad, Voss, Jan H, Garg, Jaspal, Schlegel, Jonathan G, Abdelrahman, Aliaa, Kehraus, Stefan, Reher, Raphael, Küppers, Jim, Sylvester, Katharina, Hinz, Sonja, Matthey, Michaela, Wenzel, Daniela, Fleischmann, Bernd K, Pfeifer, Alexander, Inoue, Asuka, Gütschow, Michael, König, Gabriele M, Müller, Christa E

“…G proteins are intracellular switches that transduce and amplify extracellular signals from GPCRs. The G protein subtypes, which are coupled to PLC activation,…”
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Innentitelbild: Eine einzige stabilisierende Punktmutation ermöglicht hochaufgelöste Co‐Kristallstrukturen des Adenosin‐A2A‐Rezeptors mit Preladenant‐Konjugaten (Angew. Chem. 22/2022) by Claff, Tobias, Klapschinski, Tim A., Tiruttani Subhramanyam, Udaya K., Vaaßen, Victoria J., Schlegel, Jonathan G., Vielmuth, Christin, Voß, Jan H., Labahn, Jörg, Müller, Christa E.

“…Der Adenosin‐A2A‐Rezeptor (A2AAR), der durch das extrazelluläre Nukleosid Adenosin aktiviert wird, gehört zur Familie der G‐Protein‐gekoppelten Rezeptoren…”
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Inside Cover: Single Stabilizing Point Mutation Enables High‐Resolution Co‐Crystal Structures of the Adenosine A 2A Receptor with Preladenant Conjugates (Angew. Chem. Int. Ed. 22/2022) by Claff, Tobias, Klapschinski, Tim A., Tiruttani Subhramanyam, Udaya K., Vaaßen, Victoria J., Schlegel, Jonathan G., Vielmuth, Christin, Voß, Jan H., Labahn, Jörg, Müller, Christa E.

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Inside Cover: Single Stabilizing Point Mutation Enables High‐Resolution Co‐Crystal Structures of the Adenosine A2A Receptor with Preladenant Conjugates (Angew. Chem. Int. Ed. 22/2022) by Claff, Tobias, Klapschinski, Tim A., Tiruttani Subhramanyam, Udaya K., Vaaßen, Victoria J., Schlegel, Jonathan G., Vielmuth, Christin, Voß, Jan H., Labahn, Jörg, Müller, Christa E.

“…The adenosine A2A receptor (A2AAR), which is activated by the extracellular nucleoside adenosine, belongs to the family of G protein‐coupled receptors (GPCRs)…”
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Feature-Based Molecular Networking for the Targeted Identification of G q -Inhibiting FR900359 Derivatives by Hanke, Wiebke, Patt, Julian, Alenfelder, Judith, Voss, Jan H., Zdouc, Mitja M., Kehraus, Stefan, Kim, Jung Bong, Grujičić, Goran V., Namasivayam, Vigneshwaran, Reher, Raphael, Müller, Christa E., Kostenis, Evi, Crüsemann, Max, König, Gabriele M.

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Irreversible Antagonists for the Adenosine A 2B Receptor by Temirak, Ahmed, Schlegel, Jonathan G, Voss, Jan H, Vaaßen, Victoria J, Vielmuth, Christin, Claff, Tobias, Müller, Christa E

“…Blockade of the adenosine A2B receptor (A2BAR) represents a potential novel strategy for the immunotherapy of cancer. In the present study, we designed,…”
Get full text

Crystal structure of adenosine A 2A receptor in complex with clinical candidate Etrumadenant reveals unprecedented antagonist interaction by Claff, Tobias, Schlegel, Jonathan G, Voss, Jan H, Vaaßen, Victoria J, Weiße, Renato H, Cheng, Robert K Y, Markovic-Mueller, Sandra, Bucher, Denis, Sträter, Norbert, Müller, Christa E

“…The G  protein-coupled adenosine A receptor (A AR) represents an emerging drug target for cancer immunotherapy. The clinical candidate Etrumadenant was…”
Get full text