Search Results - "Voskuyl, Rob A."

Spontaneous and optogenetically induced cortical spreading depolarization in familial hemiplegic migraine type 1 mutant mice by Loonen, Inge C.M., Voskuyl, Rob A., Schenke, Maarten, van Heiningen, Sandra H., van den Maagdenberg, Arn M.J.M., Tolner, Else A.

“…Mechanisms underlying the migraine aura are incompletely understood, which to large extent is related to a lack of models in which cortical spreading…”
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Optogenetic induction of cortical spreading depression in anesthetized and freely behaving mice by Houben, Thijs, Loonen, Inge CM, Baca, Serapio M, Schenke, Maarten, Meijer, Johanna H, Ferrari, Michel D, Terwindt, Gisela M, Voskuyl, Rob A, Charles, Andrew, van den Maagdenberg, Arn MJM, Tolner, Else A

“…Cortical spreading depression, which plays an important role in multiple neurological disorders, has been studied primarily with experimental models that use…”
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MicroRNA-124 and -137 cooperativity controls caspase-3 activity through BCL2L13 in hippocampal neural stem cells by Schouten, Marijn, Fratantoni, Silvina A., Hubens, Chantal J., Piersma, Sander R., Pham, Thang V., Bielefeld, Pascal, Voskuyl, Rob A., Lucassen, Paul J., Jimenez, Connie R., Fitzsimons, Carlos P.

“…Adult neurogenesis continuously contributes new neurons to hippocampal circuits and the programmed death of a subset of immature cells provides a primary…”
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Pharmacokinetics of Clindamycin in Pregnant Women in the Peripartum Period by MULLER, Anouk E, MOUTON, Johan W, OOSTVOGEL, Paul M, JOEP DÖRR, P, VOSKUYL, Rob A, DEJONGH, Joost, STEEGERS, Eric A. P, DANHOF, Meindert

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Synthesis and preliminary preclinical evaluation of fluorine-18 labelled isatin-4-(4-methoxyphenyl)-3-thiosemicarbazone ([18F]4FIMPTC) as a novel PET tracer of P-glycoprotein expression by Verbeek, Joost, Eriksson, Jonas, Syvänen, Stina, Huisman, Marc, Schuit, Robert C., Molthoff, Carla F. M., Voskuyl, Rob A., de Lange, Elizabeth C., Lammertsma, Adriaan A., Windhorst, Albert D.

“…Background Several P-glycoprotein (P-gp) substrate tracers are available to assess P-gp function in vivo, but attempts to develop a tracer for measuring…”
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Changes in GABAA receptor properties in amygdala kindled animals: In vivo studies using [11C]flumazenil and positron emission tomography by Liefaard, Lia C., Ploeger, Bart A., Molthoff, Carla F. M., De Jong, Hugo W. A. M., Dijkstra, Jouke, Van Der Weerd, Louise, Lammertsma, Adriaan A., Danhof, Meindert, Voskuyl, Rob A.

“…Summary Purpose:  The purpose of the present investigation was to quantify alterations in GABAA receptor density in vivo in rats subjected to amygdala…”
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(R)-[11C]verapamil PET studies to assess changes in P-glycoprotein expression and functionality in rat blood-brain barrier after exposure to kainate-induced status epilepticus by Syvänen, Stina, Luurtsema, Gert, Molthoff, Carla F M, Windhorst, Albert D, Huisman, Marc C, Lammertsma, Adriaan A, Voskuyl, Rob A, de Lange, Elizabeth C

“…Increased functionality of efflux transporters at the blood-brain barrier may contribute to decreased drug concentrations at the target site in CNS diseases…”
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Brainstem spreading depolarization and cortical dynamics during fatal seizures in Cacna1a S218L mice by Loonen, Inge C M, Jansen, Nico A, Cain, Stuart M, Schenke, Maarten, Voskuyl, Rob A, Yung, Andrew C, Bohnet, Barry, Kozlowski, Piotr, Thijs, Roland D, Ferrari, Michel D, Snutch, Terrance P, van den Maagdenberg, Arn M J M, Tolner, Else A

“…See Noebels (doi:10.1093/brain/awy356) for a scientific commentary on this article. The mechanisms underlying 'sudden unexpected death in epilepsy' (SUDEP) are…”
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Pharmacokinetics of Amoxicillin in Maternal, Umbilical Cord, and Neonatal Sera by Muller, Anouk E, Oostvogel, Paul M, DeJongh, Joost, Mouton, Johan W, Steegers, Eric A P, Dörr, P Joep, Danhof, Meindert, Voskuyl, Rob A

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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[11C]phenytoin revisited: synthesis by [11C]CO carbonylation and first evaluation as a P-gp tracer in rats by Verbeek, Joost, Eriksson, Jonas, Syvänen, Stina, Labots, Maaike, de Lange, Elizabeth C M, Voskuyl, Rob A, Mooijer, Martinus P J, Rongen, Marissa, Lammertsma, Adriaan A, Windhorst, Albert D

“…Background At present, several positron emission tomography (PET) tracers are in use for imaging P-glycoprotein (P-gp) function in man. At baseline, substrate…”
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Spontaneous spreading depolarizations originate subcortically in a novel mouse model of familial hemiplegic migraine type 2 by Jansen, Nico A., Linnenbank, Chelsey, Schenke, Maarten, Voskuyl, Rob A., Jorge, Maria S., Krivoshein, Georgii, Breukel, Cor, Linssen, Margot M., Claassens, Jill W.C., Brouwers, Conny, van Heiningen, Sandra H., Heuck, Anders, Lykke-Hartmann, Karin, Tolner, Else A., van den Maagdenberg, Arn M.J.M.

“…The mechanisms of initiation of spreading depolarization (SD) are understudied due to a paucity of disease models with spontaneously occurring events. We here…”
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Amoxicillin pharmacokinetics in pregnant women with preterm premature rupture of the membranes by Muller, Anouk E., MD, DeJongh, Joost, PhD, Oostvogel, Paul M., MD, PhD, Voskuyl, Rob A., PhD, Dörr, P. Joep, MD, PhD, Danhof, Meindert, PharmD, PhD, Mouton, Johan W., MD, PhD

“…Objective This study was undertaken to study the pharmacokinetics of intravenously administered amoxicillin in pregnant women with preterm premature rupture of…”
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Mechanism-based pharmacokinetic-pharmacodynamic (PK-PD) modeling in translational drug research by Danhof, Meindert, de Lange, Elizabeth C.M, Della Pasqua, Oscar E, Ploeger, Bart A, Voskuyl, Rob A

“…The use of pharmacokinetic-pharmacodynamic (PK-PD) modeling in translational drug research is a promising approach that provides better understanding of drug…”
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Apnea Associated with Brainstem Seizures in Cacna1a S218L Mice Is Caused by Medullary Spreading Depolarization by Jansen, Nico A, Schenke, Maarten, Voskuyl, Rob A, Thijs, Roland D, van den Maagdenberg, Arn M J M, Tolner, Else A

“…Seizure-related apnea is common and can be lethal. Its mechanisms however remain unclear and preventive strategies are lacking. We postulate that brainstem…”
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Apnea Associated with Brainstem Seizures in Cacna1aS218L Mice Is Caused by Medullary Spreading Depolarization by Jansen, Nico A, Schenke, Maarten, Voskuyl, Rob A, Thijs, Roland D, van den Maagdenberg, Arn MJM, Tolner, Else A

“…Seizure-related apnea is common and can be lethal. Its mechanisms however remain unclear and preventive strategies are lacking. We postulate that brainstem…”
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Impaired θ-γ Coupling Indicates Inhibitory Dysfunction and Seizure Risk in a Dravet Syndrome Mouse Model by Jansen, Nico A, Perez, Carlos, Schenke, Maarten, van Beurden, Anouk W, Dehghani, Anisa, Voskuyl, Rob A, Thijs, Roland D, Ullah, Ghanim, van den Maagdenberg, Arn M J M, Tolner, Else A

“…Dravet syndrome (DS) is an epileptic encephalopathy that still lacks biomarkers for epileptogenesis and its treatment. Dysfunction of Na 1.1 sodium channels,…”
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Biomarkers in epilepsy–A modelling perspective by van Dijkman, Sven C., Voskuyl, Rob A., de Lange, Elizabeth C.

“…Biomarkers can be categorised from type 0 (genotype or phenotype), through 6 (clinical scales), each level representing a part of the processes involved in the…”
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Mechanism-based pharmacokinetic -pharmacodynamic modeling : Biophase distribution, receptor theory, and dynamical systems analysis by DANHOF, Meindert, DE JONGH, Joost, DE LANGE, Elizabeth C. M, PASQUA, Oscar Della, PLOEGER, Bart A, VOSKUYL, Rob A

“…Mechanism-based PK-PD models differ from conventional PK-PD models in that they contain specific expressions to characterize, in a quantitative manner,…”
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Pharmacodynamic Analysis of the Anticonvulsant Effects of Tiagabine and Lamotrigine in Combination in the Rat by Jonker, Daniël M., Voskuyl, Rob A., Danhof, Meindert

“…Purpose: The pharmacodynamic interaction between the antiepileptic drugs (AEDs) tiagabine (TGB) and lamotrigine (LTG) was characterized on basis of the…”
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(R)-[11C]PK11195 brain uptake as a biomarker of inflammation and antiepileptic drug resistance: Evaluation in a rat epilepsy model by Bogdanović, Renée Marie, Syvänen, Stina, Michler, Christina, Russmann, Vera, Eriksson, Jonas, Windhorst, Albert D., Lammertsma, Adriaan A., de Lange, Elisabeth C., Voskuyl, Rob A., Potschka, Heidrun

“…Neuroinflammation has been suggested as a key determinant of the intrinsic severity of epilepsy. Glial cell activation and associated inflammatory signaling…”
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