Search Results - "Voskuhl, Rhonda"

All women with multiple sclerosis should start hormone replacement therapy at menopause unless contraindicated: Yes by Voskuhl, Rhonda

Get full text

A new cell subtype that confers neuroprotection by Voskuhl, Rhonda

“…A subset of neutrophils with an immature phenotype confers neuroprotection in traumatic optic nerve and spinal cord injury. This study identifies a new target…”
Get full text

The effect of sex on multiple sclerosis risk and disease progression by Voskuhl, Rhonda R

“…Sex differences in the incidence or severity of disease characterize many autoimmune and neurodegenerative diseases. Multiple sclerosis is a complex disease…”
Get full text

Sex differences in autoimmune diseases by Voskuhl, Rhonda

“…Women are more susceptible to a variety of autoimmune diseases including systemic lupus erythematosus (SLE), multiple sclerosis (MS), primary biliary…”
Get full text

It is time to conduct phase 3 clinical trials of sex hormones in MS – Yes by Voskuhl, Rhonda

Get full text

Cell specificity dictates similarities in gene expression in multiple sclerosis, Parkinson's disease, and Alzheimer's disease by Itoh, Yuichiro, Voskuhl, Rhonda R

“…Drug repurposing is an efficient approach in new treatment development since it leverages previous work from one disease to another. While multiple sclerosis…”
Get full text

Cell-specific and region-specific transcriptomics in the multiple sclerosis model: Focus on astrocytes by Itoh, Noriko, Itoh, Yuichiro, Tassoni, Alessia, Ren, Emily, Kaito, Max, Ohno, Ai, Ao, Yan, Farkhondeh, Vista, Johnsonbaugh, Hadley, Burda, Josh, Sofroniew, Michael V., Voskuhl, Rhonda R.

“…Changes in gene expression that occur across the central nervous system (CNS) during neurological diseases do not address the heterogeneity of cell types from…”
Get full text

Sex-related factors in multiple sclerosis susceptibility and progression by Voskuhl, Rhonda R., Gold, Stefan M.

“…The higher incidence of multiple sclerosis (MS) in women than in men is widely acknowledged in the literature. The role of sex-related factors is, therefore,…”
Get full text

Gene expression in oligodendrocytes during remyelination reveals cholesterol homeostasis as a therapeutic target in multiple sclerosis by Voskuhl, Rhonda R., Itoh, Noriko, Tassoni, Alessia, Matsukawa, Macy Akiyo, Ren, Emily, Tse, Vincent, Jang, Ellis, Suen, Timothy Takazo, Itoh, Yuichiro

“…Regional differences in neurons, astrocytes, oligodendrocytes, and microglia exist in the brain during health, and regional differences in the transcriptome…”
Get full text

Neuroprotective effects of estrogens and androgens in CNS inflammation and neurodegeneration by Spence, Rory D, Voskuhl, Rhonda R

“…Highlights ► Effects of estrogens and androgens in neuroinflammation and neurodegeneration. ► Effects of estrogens on receptors in the immune and central…”
Get full text

The astrocyte transcriptome in EAE optic neuritis shows complement activation and reveals a sex difference in astrocytic C3 expression by Tassoni, Alessia, Farkhondeh, Vista, Itoh, Yuichiro, Itoh, Noriko, Sofroniew, Michael V., Voskuhl, Rhonda R.

“…Multiple sclerosis (MS) is a neuroinflammatory multifocal disorder. Optic neuritis is common in MS and leads to visual disability. No current treatments repair…”
Get full text

The X-linked histone demethylase Kdm6a in CD4+ T lymphocytes modulates autoimmunity by Itoh, Yuichiro, Golden, Lisa C, Itoh, Noriko, Matsukawa, Macy Akiyo, Ren, Emily, Tse, Vincent, Arnold, Arthur P, Voskuhl, Rhonda R

“…Multiple sclerosis (MS) is a putative T cell-mediated autoimmune disease. As with many autoimmune diseases, females are more susceptible than males. Sexual…”
Get full text

Chronic experimental autoimmune encephalomyelitis is an excellent model to study neuroaxonal degeneration in multiple sclerosis by Voskuhl, Rhonda R., MacKenzie-Graham, Allan

“…Animal models of multiple sclerosis (MS), specifically experimental autoimmune encephalomyelitis (EAE), have been used extensively to develop anti-inflammatory…”
Get full text

Sex chromosome contributions to sex differences in multiple sclerosis susceptibility and progression by Voskuhl, Rhonda R, Sawalha, Amr H, Itoh, Yuichiro

“…Background: Why are women more susceptible to multiple sclerosis, but men have worse disability progression? Sex differences in disease may be due to sex…”
Get full text

XY sex chromosome complement, compared with XX, in the CNS confers greater neurodegeneration during experimental autoimmune encephalomyelitis by Du, Sienmi, Itoh, Noriko, Askarinam, Sahar, Hill, Haley, Arnold, Arthur P., Voskuhl, Rhonda R.

“…Women are more susceptible to multiple sclerosis (MS) and have more robust immune responses than men. However, men with MS tend to demonstrate a more…”
Get full text

Parent-of-origin differences in DNA methylation of X chromosome genes in T lymphocytes by Golden, Lisa C., Itoh, Yuichiro, Itoh, Noriko, Iyengar, Sonia, Coit, Patrick, Salama, Youstina, Arnold, Arthur P., Sawalha, Amr H., Voskuhl, Rhonda R.

“…Many autoimmune diseases are more frequent in females than in males in humans and their mouse models, and sex differences in immune responses have been shown…”
Get full text

B-Cell Depletion and COVID-19 Severity in Multiple Sclerosis: Remaining Challenges by Killestein, Joep, Schoonheim, Menno M., Voskuhl, Rhonda R.

Get full text

Reactive Astrocytes Form Scar-Like Perivascular Barriers to Leukocytes during Adaptive Immune Inflammation of the CNS by Voskuhl, Rhonda R, Peterson, R. Scott, Song, Bingbing, Ao, Yan, Morales, Laurie Beth J, Tiwari-Woodruff, Seema, Sofroniew, Michael V

“…Factors that regulate leukocyte entry and spread through CNS parenchyma during different types of CNS insults are incompletely understood. Reactive astrocytes…”
Get full text

Astrocyte CCL2 sustains immune cell infiltration in chronic experimental autoimmune encephalomyelitis by Kim, Roy Y, Hoffman, Alexandria S, Itoh, Noriko, Ao, Yan, Spence, Rory, Sofroniew, Michael V, Voskuhl, Rhonda R

“…Abstract Chemokine (C-C motif) ligand 2 (CCL2), initially identified as monocyte chemoattractant protein-1 (MCP-1), recruits immune cells to the central…”
Get full text

Estrogen receptor beta in astrocytes modulates cognitive function in mid-age female mice by Itoh, Noriko, Itoh, Yuichiro, Meyer, Cassandra E., Suen, Timothy Takazo, Cortez-Delgado, Diego, Rivera Lomeli, Michelle, Wendin, Sophia, Somepalli, Sri Sanjana, Golden, Lisa C., MacKenzie-Graham, Allan, Voskuhl, Rhonda R.

“…Menopause is associated with cognitive deficits and brain atrophy, but the brain region and cell-specific mechanisms are not fully understood. Here, we…”
Get full text