Search Results - "Voskoboinik, Ilia"

Perforin and granzymes: function, dysfunction and human pathology by Voskoboinik, Ilia, Whisstock, James C., Trapani, Joseph A.

“…Key Points This article reviews recent advances in the structural, cellular and clinical aspects of perforin and granzyme biology. It describes the cellular…”
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Reprogrammed CRISPR-Cas13b suppresses SARS-CoV-2 replication and circumvents its mutational escape through mismatch tolerance by Fareh, Mohamed, Zhao, Wei, Hu, Wenxin, Casan, Joshua M. L., Kumar, Amit, Symons, Jori, Zerbato, Jennifer M., Fong, Danielle, Voskoboinik, Ilia, Ekert, Paul G., Rudraraju, Rajeev, Purcell, Damian F. J., Lewin, Sharon R., Trapani, Joseph A.

“…The recent dramatic appearance of variants of concern of SARS-coronavirus-2 (SARS-CoV-2) highlights the need for innovative approaches that simultaneously…”
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Failed CTL/NK cell killing and cytokine hypersecretion are directly linked through prolonged synapse time by Jenkins, Misty R, Rudd-Schmidt, Jesse A, Lopez, Jamie A, Ramsbottom, Kelly M, Mannering, Stuart I, Andrews, Daniel M, Voskoboinik, Ilia, Trapani, Joseph A

“…Failure of cytotoxic T lymphocytes (CTLs) or natural killer (NK) cells to kill target cells by perforin (Prf)/granzyme (Gzm)-induced apoptosis causes severe…”
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Lipid order and charge protect killer T cells from accidental death by Rudd-Schmidt, Jesse A., Hodel, Adrian W., Noori, Tahereh, Lopez, Jamie A., Cho, Hyun-Jung, Verschoor, Sandra, Ciccone, Annette, Trapani, Joseph A., Hoogenboom, Bart W., Voskoboinik, Ilia

“…Killer T cells (cytotoxic T lymphocytes, CTLs) maintain immune homoeostasis by eliminating virus-infected and cancerous cells. CTLs achieve this by forming an…”
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Perforin forms transient pores on the target cell plasma membrane to facilitate rapid access of granzymes during killer cell attack by Lopez, Jamie A., Susanto, Olivia, Jenkins, Misty R., Lukoyanova, Natalya, Sutton, Vivien R., Law, Ruby H.P., Johnston, Angus, Bird, Catherina H., Bird, Phillip I., Whisstock, James C., Trapani, Joseph A., Saibil, Helen R., Voskoboinik, Ilia

“…Cytotoxic lymphocytes serve a key role in immune homeostasis by eliminating virus-infected and transformed target cells through the perforin-dependent delivery…”
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Real-time visualization of perforin nanopore assembly by Leung, Carl, Hodel, Adrian W., Brennan, Amelia J., Lukoyanova, Natalya, Tran, Sharon, House, Colin M., Kondos, Stephanie C., Whisstock, James C., Dunstone, Michelle A., Trapani, Joseph A., Voskoboinik, Ilia, Saibil, Helen R., Hoogenboom, Bart W.

“…Perforin is a key protein of the vertebrate immune system. Secreted by cytotoxic lymphocytes as soluble monomers, perforin can self-assemble into oligomeric…”
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Perforin: structure, function, and role in human immunopathology by Voskoboinik, Ilia, Dunstone, Michelle A, Baran, Katherine, Whisstock, James C, Trapani, Joseph A

“…The secretory granule-mediated cell death pathway is the key mechanism for elimination of virus-infected and transformed target cells by cytotoxic lymphocytes…”
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The cryo-EM structure of the acid activatable pore-forming immune effector Macrophage-expressed gene 1 by Pang, Siew Siew, Bayly-Jones, Charles, Radjainia, Mazdak, Spicer, Bradley A., Law, Ruby H. P., Hodel, Adrian W., Parsons, Edward S., Ekkel, Susan M., Conroy, Paul J., Ramm, Georg, Venugopal, Hariprasad, Bird, Phillip I., Hoogenboom, Bart W., Voskoboinik, Ilia, Gambin, Yann, Sierecki, Emma, Dunstone, Michelle A., Whisstock, James C.

“…Macrophage-expressed gene 1 (MPEG1/Perforin-2) is a perforin-like protein that functions within the phagolysosome to damage engulfed microbes. MPEG1 is thought…”
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The structural basis for membrane binding and pore formation by lymphocyte perforin by Trapani, Joseph A, Saibil, Helen R, Whisstock, James C, Law, Ruby H. P, Lukoyanova, Natalya, Voskoboinik, Ilia, Caradoc-Davies, Tom T, Baran, Katherine, Dunstone, Michelle A, D'Angelo, Michael E, Orlova, Elena V, Coulibaly, Fasséli, Verschoor, Sandra, Browne, Kylie A, Ciccone, Annette, Kuiper, Michael J, Bird, Phillip I

“…Natural killer cells and cytotoxic T lymphocytes accomplish the critically important function of killing virus-infected and neoplastic cells. They do this by…”
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Differential effects of BTK inhibitors ibrutinib and zanubrutinib on NK-cell effector function in patients with mantle cell lymphoma by Flinsenberg, Thijs W H, Tromedjo, Charnelle C, Hu, Nan, Liu, Ye, Guo, Yin, Thia, Kevin Y T, Noori, Tahereh, Song, Xiaomin, Aw Yeang, Han X, Tantalo, Daniela G, Handunnetti, Sasanka, Seymour, John F, Roberts, Andrew W, Ritchie, David, Koldej, Rachel, Neeson, Paul J, Wang, Lai, Trapani, Joseph A, Tam, Constantine S, Voskoboinik, Ilia

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Conformational changes during pore formation by the perforin-related protein pleurotolysin by Lukoyanova, Natalya, Kondos, Stephanie C, Farabella, Irene, Law, Ruby H P, Reboul, Cyril F, Caradoc-Davies, Tom T, Spicer, Bradley A, Kleifeld, Oded, Traore, Daouda A K, Ekkel, Susan M, Voskoboinik, Ilia, Trapani, Joseph A, Hatfaludi, Tamas, Oliver, Katherine, Hotze, Eileen M, Tweten, Rodney K, Whisstock, James C, Topf, Maya, Saibil, Helen R, Dunstone, Michelle A

“…Membrane attack complex/perforin-like (MACPF) proteins comprise the largest superfamily of pore-forming proteins, playing crucial roles in immunity and…”
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ALFA-PRF: a novel approach to detect murine perforin release from CTLs into the immune synapse by Rudd-Schmidt, Jesse A, Laine, Romain F, Noori, Tahereh, Brennan, Amelia J, Voskoboinik, Ilia

“…When killing through the granule exocytosis pathway, cytotoxic lymphocytes release key effector molecules into the immune synapse, perforin and granzymes, to…”
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MACPF/CDC family of pore-forming toxins by Rosado, Carlos J, Kondos, Stephanie, Bull, Tara E, Kuiper, Michael J, Law, Ruby H.P, Buckle, Ashley M, Voskoboinik, Ilia, Bird, Phillip I, Trapani, Joseph A, Whisstock, James C, Dunstone, Michelle A

“…Pore-forming toxins (PFTs) are commonly associated with bacterial pathogenesis. In eukaryotes, however, PFTs operate in the immune system or are deployed for…”
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The battlefield of perforin/granzyme cell death pathways by Hoves, Sabine, Trapani, Joseph A., Voskoboinik, Ilia

“…The review discusses the controversies in the field of cytotoxic lymphocyte secretory granule death pathways. A pore‐forming protein, PRF, and serine…”
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Temperature sensitivity of human perforin mutants unmasks subtotal loss of cytotoxicity, delayed FHL, and a predisposition to cancer by Chia, Jenny, Yeo, Kim Pin, Whisstock, James C, Dunstone, Michelle A, Trapani, Joseph A, Voskoboinik, Ilia

“…The pore-forming protein perforin is critical for defense against many human pathogens and for preventing a catastrophic collapse of immune homeostasis,…”
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Pharmacologic inhibition of dipeptidyl peptidase 1 (cathepsin C) does not block in vitro granzyme-mediated target cell killing by CD8 T or NK cells by Sutton, Vivien R, Watt, Sally V, Akhlaghi, Hedieh, Cipolla, David C, Chen, Kuan-Ju, LaSala, Daniel, McDonald, Patrick P, Beavis, Paul A, Munoz, Isabelle, Hodel, Adrian W, Noori, Tahereh, Voskoboinik, Ilia, Trapani, Joseph A

“…Recently developed small-molecule inhibitors of the lysosomal protease dipeptidyl peptidase 1 (DPP1), also known as cathepsin C (CatC), can suppress…”
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Dilemmas in the diagnosis and pathogenesis of atypical late‐onset familial haemophagocytic lymphohistiocytosis by Minson, Adrian, Voskoboinik, Ilia, Grigg, Andrew

“…Objectives A congenital loss of cytotoxic lymphocyte activity leads to a potentially fatal immune dysregulation, familial haemophagocytic lymphohistiocytosis…”
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The Molecular Basis for Perforin Oligomerization and Transmembrane Pore Assembly by Baran, Katherine, Dunstone, Michelle, Chia, Jenny, Ciccone, Annette, Browne, Kylie A., Clarke, Christopher J.P., Lukoyanova, Natalya, Saibil, Helen, Whisstock, James C., Voskoboinik, Ilia, Trapani, Joseph A.

“…Perforin, a pore-forming protein secreted by cytotoxic lymphocytes, is indispensable for destroying virus-infected cells and for maintaining immune…”
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Common Fold Mediates Vertebrate Defense and Bacterial Attack by Rosado, Carlos J, Buckle, Ashley M, Law, Ruby H.P, Butcher, Rebecca E, Kan, Wan-Ting, Bird, Catherina H, Ung, Kheng, Browne, Kylie A, Baran, Katherine, Bashtannyk-Puhalovich, Tanya A, Faux, Noel G, Wong, Wilson, Porter, Corrine J, Pike, Robert N, Ellisdon, Andrew M, Pearce, Mary C, Bottomley, Stephen P, Emsley, Jonas, Smith, A. Ian, Rossjohn, Jamie, Hartland, Elizabeth L, Voskoboinik, Ilia, Trapani, Joseph A, Bird, Phillip I, Dunstone, Michelle A, Whisstock, James C

“…Proteins containing membrane attack complex/perforin (MACPF) domains play important roles in vertebrate immunity, embryonic development, and neural-cell…”
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Protection from Endogenous Perforin: Glycans and the C Terminus Regulate Exocytic Trafficking in Cytotoxic Lymphocytes by Brennan, Amelia J., Chia, Jenny, Browne, Kylie A., Ciccone, Annette, Ellis, Sarah, Lopez, Jamie A., Susanto, Olivia, Verschoor, Sandra, Yagita, Hideo, Whisstock, James C., Trapani, Joseph A., Voskoboinik, Ilia

“…Cytotoxic lymphocyte-mediated apoptosis is dependent on the delivery of perforin to secretory granules and its ability to form calcium-dependent pores in the…”
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