Search Results - "Vosjan, Maria J W D"

A biparatopic anti‐EGFR nanobody efficiently inhibits solid tumour growth by Roovers, Rob C., Vosjan, Maria J.W.D., Laeremans, Toon, el Khoulati, Rachid, de Bruin, Renée C.G., Ferguson, Kathryn M., Verkleij, Arie J., van Dongen, Guus A.M.S., van Bergen en Henegouwen, Paul M.P.

“…The epidermal growth factor receptor (EGFR) has been shown to be a valid cancer target for antibody‐based therapy. At present, several anti‐EGFR monoclonal…”
Get full text

p-Isothiocyanatobenzyl-desferrioxamine: a new bifunctional chelate for facile radiolabeling of monoclonal antibodies with zirconium-89 for immuno-PET imaging by Perk, Lars R., Vosjan, Maria J. W. D., Visser, Gerard W. M., Budde, Marianne, Jurek, Paul, Kiefer, Garry E., van Dongen, Guus A. M. S.

“…Purpose Immuno-PET is an emerging imaging tool for the selection of high potential antibodies (mAbs) for imaging and therapy. The positron emitter zirconium-89…”
Get full text

Evaluating N‐difluoromethyltriazolium triflate as a precursor for the synthesis of high molar activity [18F]fluoroform by Pees, Anna, Vosjan, Maria J. W. D., Chai, Jin Young, Cha, Hyojin, Chi, Dae Yoon, Windhorst, Albert D., Vugts, Danielle J.

“…The trifluoromethyl group is a prominent motif in biologically active compounds and therefore of great interest for the labeling with the positron emitter…”
Get full text

Conjugation and radiolabeling of monoclonal antibodies with zirconium-89 for PET imaging using the bifunctional chelate p -isothiocyanatobenzyl-desferrioxamine by van Dongen, Guus A M S, Vosjan, Maria J W D, Perk, Lars R, Visser, Gerard W M, Budde, Marianne, Jurek, Paul, Kiefer, Garry E

“…The positron emitter zirconium-89 ( 89 Zr) has very attractive properties for positron emission tomography (PET) imaging of intact monoclonal antibodies (mAbs)…”
Get full text

Synthesis of [18F]Fluoroform with High Molar Activity by Pees, Anna, Windhorst, Albert D., Vosjan, Maria J. W. D., Tadino, Vincent, Vugts, Danielle J.

“…Fluoroform is an interesting motif for the isotopologue labelling of biologically active compounds with fluorine‐18 for PET imaging. However, so far the…”
Get full text

Nanobodies targeting the hepatocyte growth factor: potential new drugs for molecular cancer therapy by Vosjan, Maria J W D, Vercammen, Jo, Kolkman, Joost A, Stigter-van Walsum, Marijke, Revets, Hilde, van Dongen, Guus A M S

“…Hepatocyte growth factor (HGF) and its receptor c-Met are associated with increased aggressiveness of tumors and poor prognostic outcome of patients with…”
Get full text

Synthesis and evaluation of [18F]cinacalcet for the imaging of parathyroid hyperplasia by Pees, Anna, Beaino, Wissam, Kooijman, Esther J.M., Schreurs, Maxime, Verlaan, Mariska, Schuit, Robert C., Vosjan, Maria J.W.D., Engelsman, Anton F., Windhorst, Albert D., Vugts, Danielle J.

“…Parathyroid hyperplasia is a disease characterized by overactive parathyroid glands secreting increased levels of parathyroid hormone. Surgical removal of the…”
Get full text

Quantitative PET imaging of Met-expressing human cancer xenografts with 89Zr-labelled monoclonal antibody DN30 by Perk, Lars R., Stigter-van Walsum, Marijke, Visser, Gerard W. M., Kloet, Reina W., Vosjan, Maria J. W. D., Leemans, C. René, Giaccone, Giuseppe, Albano, Raffaella, Comoglio, Paolo M., van Dongen, Guus A. M. S.

“…Purpose Targeting the c-Met receptor with monoclonal antibodies (MAbs) is an appealing approach for cancer diagnosis and treatment because this receptor plays…”
Get full text

Immuno-positron emission tomography: shedding light on clinical antibody therapy by van Dongen, Guus A M S, Vosjan, Maria J W D

“…Summation Monoclonal antibodies (mAbs) have been approved for therapeutic use in a broad range of medical indications, especially in oncology, and are forming…”
Get more information

High-quality 124I-labelled monoclonal antibodies for use as PET scouting agents prior to 131I-radioimmunotherapy by Verel, Iris, Visser, Gerard W M, Vosjan, Maria J W D, Finn, Ronald, Boellaard, Ronald, van Dongen, Guus A M S

“…Monoclonal antibodies (MAbs) labelled with 124I are an attractive option for quantitative imaging with positron emission tomography (PET) in a scouting…”
Get full text

Biodistribution, radiation dosimetry and scouting of 90Y-ibritumomab tiuxetan therapy in patients with relapsed B-cell non-Hodgkin’s lymphoma using 89Zr-ibritumomab tiuxetan and PET by Rizvi, Saiyada N. F., Visser, Otto J., Vosjan, Maria J. W. D., van Lingen, Arthur, Hoekstra, Otto S., Zijlstra, Josée M., Huijgens, Peter C., van Dongen, Guus A. M. S., Lubberink, Mark

“…Purpose Positron emission tomography (PET) with 89 Zr-ibritumomab tiuxetan can be used to monitor biodistribution of 90 Y-ibritumomab tiuxetan as shown in…”
Get full text

Facile labelling of an anti-epidermal growth factor receptor Nanobody with 68Ga via a novel bifunctional desferal chelate for immuno-PET by Vosjan, Maria J. W. D., Perk, Lars R., Roovers, Rob C., Visser, Gerard W. M., Stigter-van Walsum, Marijke, van Bergen en Henegouwen, Paul M. P., van Dongen, Guus A. M. S.

“…Purpose The ∼15 kDa variable domains of camelid heavy-chain-only antibodies (called Nanobodies®) have the flexibility to be formatted as monovalent,…”
Get full text

Discordance of genetic alterations between primary head and neck tumors and corresponding metastases associated with mutational status of the TP53 gene by Tabor, Maarten P., van Houten, Viola M. M., Kummer, J. Alain, Vosjan, Maria J. W. D., Vlasblom, Ronald, Snow, Gordon B., Leemans, C. René, Braakhuis, Boudewijn J. M., Brakenhoff, Ruud H.

“…Ample molecular data are available on the progression from normal mucosa to invasive head and neck squamous cell carcinoma (HNSCC), but information on further…”
Get full text

Evaluating N-difluoromethyltriazolium triflate as a precursor for the synthesis of high molar activity 18 Ffluoroform by Pees, Anna, Vosjan, Maria J W D, Chai, Jin Young, Cha, Hyojin, Chi, Dae Yoon, Windhorst, Albert D, Vugts, Danielle J

“…The trifluoromethyl group is a prominent motif in biologically active compounds and therefore of great interest for the labeling with the positron emitter…”
Get full text

Fully Automated 89Zr Labeling and Purification of Antibodies by Poot, Alex J, Adamzek, Kevin WA, Windhorst, Albert D, Vosjan, Maria JWD, Kropf, Saskia, Wester, Hans-Jurgen, van Dongen, Guus AMS, Vugts, Danielle J

“…Dozens of monoclonal antibodies (mAbs) have been approved for clinical use, and hundreds more are under development. To support these developments and…”
Get full text

Fully Automated 89 Zr Labeling and Purification of Antibodies by Poot, Alex J, Adamzek, Kevin W A, Windhorst, Albert D, Vosjan, Maria J W D, Kropf, Saskia, Wester, Hans-Jurgen, van Dongen, Guus A M S, Vugts, Danielle J

“…Dozens of monoclonal antibodies (mAbs) have been approved for clinical use, and hundreds more are under development. To support these developments and…”
Get full text

(89)Zr as a PET surrogate radioisotope for scouting biodistribution of the therapeutic radiometals (90)Y and (177)Lu in tumor-bearing nude mice after coupling to the internalizing antibody cetuximab by Perk, Lars R, Visser, Gerard W M, Vosjan, Maria J W D, Stigter-van Walsum, Marijke, Tijink, Bernard M, Leemans, C René, van Dongen, Guus A M S

“…Immuno-PET as a scouting procedure before radioimmunotherapy (RIT) aims at confirming tumor targeting and accurately estimating radiation dose delivery to both…”
Get full text

Performance of Immuno–Positron Emission Tomography with Zirconium-89-Labeled Chimeric Monoclonal Antibody U36 in the Detection of Lymph Node Metastases in Head and Neck Cancer Patients by Börjesson, Pontus K E, Jauw, Yvonne W S, Boellaard, Ronald, de Bree, Remco, Comans, Emile F I, Roos, Jan C, Castelijns, Jonas A, Vosjan, Maria J W D, Kummer, J Alain, Leemans, C René, Lammertsma, Adriaan A, van Dongen, Guus A M S

“…Purpose: Immuno–positron emission tomography (PET), the combination of PET with monoclonal antibodies (mAb), is an attractive option to improve tumor detection…”
Get full text

Preparation and evaluation of (89)Zr-Zevalin for monitoring of (90)Y-Zevalin biodistribution with positron emission tomography by Perk, Lars R, Visser, Otto J, Stigter-van Walsum, M, Vosjan, Maria J W D, Visser, Gerard W M, Zijlstra, Josée M, Huijgens, Peter C, van Dongen, Guus A M S

“…To evaluate whether (89)Zr can be used as a PET surrogate label for quantification of (90)Y-ibritumomab tiuxetan ((90)Y-Zevalin) biodistribution and dosimetry…”
Get full text

Synthesis and evaluation of 18Fcinacalcet for the imaging of parathyroid hyperplasia by Pees, Anna, Beaino, Wissam, Kooijman, Esther J M, Schreurs, Maxime, Verlaan, Mariska, Schuit, Robert C, Vosjan, Maria J W D, Engelsman, Anton F, Windhorst, Albert D, Vugts, Danielle J

“…Parathyroid hyperplasia is a disease characterized by overactive parathyroid glands secreting increased levels of parathyroid hormone. Surgical removal of the…”
Get full text