Search Results - "Vorwerk, CK"

Different Activation of Mitogen-Activated Protein Kinase and Akt Signaling Is Associated with Aggressive Phenotype of Human Meningiomas by MAWRIN, Christian, SASSE, Tina, DIETZMANN, Knut, KIRCHES, Elmar, KROPF, Siegfried, SCHNEIDER, Thomas, GRIMM, Christoph, PAMBOR, Claudia, VORWERK, Christian K, FIRSCHING, Raimund, LENDECKEL, Uwe

“…Purpose: Activation of intracellular signaling cascades has been implicated in the growth control of benign meningiomas, but their role for meningioma…”
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Traumatic Axonal Injury Results in Biphasic Calpain Activation and Retrograde Transport Impairment in Mice by Saatman, Kathryn E., Abai, Babak, Grosvenor, Ashley, Vorwerk, Christian K., Smith, Douglas H., Meaney, David F.

“…Traumatic axonal injury (TAI) is one of the most important pathologies associated with closed head injury, and contributes to ensuing morbidity. The authors…”
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Concurrent Downregulation of a Glutamate Transporter and Receptor in Glaucoma by Naskar, Rita, Vorwerk, Christian K, Dreyer, Evan B

“…Elevated levels of extracellular glutamate have been implicated in the pathophysiology of neuronal loss in both central nervous system and ophthalmic…”
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Combined Topical Fluconazole and Corticosteroid Treatment for Experimental Candida albicans Keratomycosis by Schreiber, Wolfram, Olbrisch, Antje, Vorwerk, Christian K, Konig, Wolfgang, Behrens-Baumann, Wolfgang

“…To determine the most efficient time point and concentration of topical corticosteroids in Candida albicans keratitis treated with fluconazole. Corneas of 105…”
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Depression of Retinal Glutamate Transporter Function Leads to Elevated Intravitreal Glutamate Levels and Ganglion Cell Death by Vorwerk, Christian K, Naskar, Rita, Schuettauf, Frank, Quinto, Kristine, Zurakowski, David, Gochenauer, Gordon, Robinson, Michael B, Mackler, Scott A, Dreyer, Evan B

“…Elevated levels of extracellular glutamate have been implicated in the pathophysiology of neuronal loss in both central nervous system and ophthalmic…”
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Hereditary Lattice Corneal Dystrophy Is Associated with Corneal Amyloid Deposits Enclosing C-Terminal Fragments of Keratoepithelin by Stix, Barbara, Leber, Martina, Bingemer, Peter, Gross, Christof, Ruschoff, Josef, Fandrich, Marcus, Schorderet, Daniel F, Vorwerk, Christian K, Zacharias, Martin, Roessner, Albert, Rocken, Christoph

“…To investigate the molecular basis of hereditary lattice corneal dystrophy (LCD) type IIIA associated with corneal amyloid deposits afflicting several members…”
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Chronic low-dose glutamate is toxic to retinal ganglion cells. Toxicity blocked by memantine by Vorwerk, CK, Lipton, SA, Zurakowski, D, Hyman, BT, Sabel, BA, Dreyer, EB

“…It is well known that acute exposure to high concentrations of glutamate is toxic to central mammalian neurons. However, the effect of a chronic, minor…”
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Ethambutol is toxic to retinal ganglion cells via an excitotoxic pathway by Heng, JE, Vorwerk, CK, Lessell, E, Zurakowski, D, Levin, LA, Dreyer, EB

“…Ethambutol is an essential medication in the management of tuberculosis. However, it can cause an optic neuropathy of uncertain etiology. Ethambutol toxicity…”
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Prognostic relevance of MAPK expression in glioblastoma multiforme by Mawrin, Christian, Diete, Sabine, Treuheit, Tim, Kropf, Siegfried, Vorwerk, Christian K, Boltze, Carsten, Kirches, Elmar, Firsching, Raimund, Dietzmann, Knut

“…The objective of this study was to determine the immunoexpression pattern of the mitogen-activated protein kinase (MAPK), and related signalling proteins…”
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Region-specific analysis of mitochondrial DNA deletions in neurodegenerative disorders in humans by Mawrin, Christian, Kirches, Elmar, Krause, Guido, Schneider-Stock, Regine, Bogerts, Bernhard, Vorwerk, Christian K., Dietzmann, Knut

“…Mitochondrial dysfunction caused by mitochondrial DNA (mtDNA) aberrations has been implicated in the neuronal death in neurodegenerative disorders. Significant…”
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An Experimental Basis for Implicating Excitotoxicity in Glaucomatous Optic Neuropathy by Vorwerk, Christian K, Gorla, Madhu S.R, Dreyer, Evan B

“…Most therapy for glaucoma is directed at the management of the intraocular pressure (IOP). Conventional wisdom holds that excessive pressure within the eye…”
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Effects of axonal injury on ganglion cell survival and glutamate homeostasis by Vorwerk, Christian K., Zurakowski, David, McDermott, Luann M., Mawrin, Christian, Dreyer, Evan B.

“…Axonal trauma leads to a series of pathologic events that can culminate in neuronal death. Optic nerve crush can be used to explore histologic and molecular…”
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Ganglion Cell Loss after Optic Nerve Crush Mediated through AMPA-Kainate and NMDA Receptors by Schuettauf, Frank, Naskar, Rita, Vorwerk, Christian K, Zurakowski, David, Dreyer, Evan B

“…Glutamate antagonists can block ganglion cell death due to optic nerve crush. Although most investigators have focused on blockade of the N-methyl-D-aspartate…”
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Single-cell analysis of mtDNA deletion levels in sporadic amyotrophic lateral sclerosis by Mawrin, Christian, Kirches, Elmar, Krause, Guido, Wiedemann, Falk R, Vorwerk, Christian K, Bogerts, Bernhard, Schildhaus, Hans-Ulrich, Dietzmann, Knut, Schneider-Stock, Regine

“…One possible cause for the neuronal loss in sporadic amyotrophic lateral sclerosis (S-ALS) is an increase of free radicals, which may produce oxidative damage…”
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Expression and Function of Somatostatin Receptors in Peripheral Nerve Sheath Tumors by Mawrin, Christian, Schulz, Stefan, Hellwig-Patyk, Anja, Kirches, Elmar, Roessner, Albert, Lendeckel, Uwe, Firsching, Raimund, Vorwerk, Christian K, Keilhoff, Gerburg, Dietzmann, Knut, Grimm, Kirsten, Lindberg, Guy, Gutmann, David H, Scheithauer, Bernd W, Perry, Arie

“…ABSTRACTAlthough somatostatin receptors have been detected in many normal and neoplastic tissues, little is known of their expression and function in…”
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Alterations of cell cycle regulators in gliomatosis cerebri by MAWRIN, Christian, KIRCHES, Elmar, DIETZMANN, Knut, SCHNEIDER-STOCK, Regine, BOLTZE, Carsten, VORWERK, Christian K, VON DEIMLING, Andreas, STOLTENBURG -DIDINGER, Gisela, BORNEMANN, Antje, ROMEIKE, Bernd, SELLHAUS, Bernd

“…Gliomatosis cerebri (GC) is regarded as a rare glial neoplasm of unknown origin, and a detailed analysis of molecular alterations underlying this disease has…”
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Axonal Injury Alters Alternative Splicing of the Retinal NR1 Receptor: the Preferential Expression of the NR1b Isoforms Is Crucial for Retinal Ganglion Cell Survival by Kreutz, Michael R, Bockers, Tobias M, Bockmann, Jurgen, Seidenbecher, Constanze I, Kracht, Bettina, Vorwerk, Christian K, Weise, Jens, Sabel, Bernhard A

“…Cellular-specific splicing of the retinal NMDAR1 receptor (NR1) and expression of NMDAR2 receptor (NR2) subunits in response to optic nerve injury was…”
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The role of neuronal and endothelial nitric oxide synthase in retinal excitotoxicity by Vorwerk, CK, Hyman, BT, Miller, JW, Husain, D, Zurakowski, D, Huang, PL, Fishman, MC, Dreyer, EB

“…Nitric oxide synthase (NOS) plays an essential role in neuronal function and is critical in the brain for normal and pathologic responses to glutamate. The…”
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Ganglioside patterns in human spinal cord by VORWERK, C. K

“…To examine the distribution of gangliosides in human cervical and lumbar spinal cord. Magdeburg, Germany. The ganglioside distribution of human cervical and…”
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Systemic L-kynurenine administration partially protects against NMDA, but not kainate-induced degeneration of retinal ganglion cells, and reduces visual discrimination deficits in adult rats by VORWERK, C. K, KREUTZ, M. R, DREYER, E. B, SABEL, B. A

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