Synthesis and structural study of piperazine-2,5-diones derived from (R)-cysteine
Coupling Leuch's anhydrides obtained from (R)-thiazolidine-4-carboxylic acids 1 and 3 with one equivalent of the corresponding ethyl ester derivative of 1 or 3, leads to the formation of chiral piperazine-2,5-diones 2, 4, 5, 6, and 7, on thermal treatment of the intermediate dipeptides. The con...
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| Published in: | Tetrahedron: asymmetry Vol. 6; no. 6; pp. 1357 - 1366 |
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| Main Authors: | , , |
| Format: | Journal Article |
| Language: | English |
| Published: |
Elsevier Ltd
01-06-1995
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| Online Access: | Get full text |
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| Summary: | Coupling Leuch's anhydrides obtained from (R)-thiazolidine-4-carboxylic acids
1 and
3 with one equivalent of the corresponding ethyl ester derivative of
1 or
3, leads to the formation of chiral piperazine-2,5-diones
2, 4, 5, 6, and
7, on thermal treatment of the intermediate dipeptides. The configuration of the products was established by nOe experiments.
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| ISSN: | 0957-4166 1362-511X |
| DOI: | 10.1016/0957-4166(95)00168-O |