Search Results - "Vornhagen, Jay"

Gut community structure as a risk factor for infection in Klebsiella pneumoniae -colonized patients by Vornhagen, Jay, Rao, Krishna, Bachman, Michael A

“…The primary risk factor for infection with members of the species complex is prior gut colonization, and infection is often caused by the colonizing strain…”
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A systematic analysis of hypermucoviscosity and capsule reveals distinct and overlapping genes that impact Klebsiella pneumoniae fitness by Mike, Laura A, Stark, Andrew J, Forsyth, Valerie S, Vornhagen, Jay, Smith, Sara N, Bachman, Michael A, Mobley, Harry L T

“…Hypervirulent K. pneumoniae (hvKp) is a distinct pathotype that causes invasive community-acquired infections in healthy individuals. Hypermucoviscosity (hmv)…”
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A structured professional development curriculum for postdoctoral fellows leads to recognized knowledge growth by Steen, Kaylee, Vornhagen, Jay, Weinberg, Zara Y, Boulanger-Bertolus, Julie, Rao, Arvind, Gardner, Margery Evans, Subramanian, Shoba

“…Postdoctoral training enables research independence and professional readiness. National reports have emphasized professional development as a critical…”
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Lipid analogs reveal features critical for hemolysis and diminish granadaene mediated Group B Streptococcus infection by Armistead, Blair, Herrero-Foncubierta, Pilar, Coleman, Michelle, Quach, Phoenicia, Whidbey, Christopher, Justicia, Jose, Tapia, Ruben, Casares, Raquel, Millán, Alba, Haidour, Ali, Granger, Javier Rodriguez, Vornhagen, Jay, Santana-Ufret, Verónica, Merillat, Sean, Adams Waldorf, Kristina, Cuerva, Juan Manuel, Rajagopal, Lakshmi

“…Although certain microbial lipids are toxins, the structural features important for cytotoxicity remain unknown. Increased functional understanding is…”
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The Klebsiella pneumoniae citrate synthase gene, gltA, influences site specific fitness during infection by Vornhagen, Jay, Sun, Yuang, Breen, Paul, Forsyth, Valerie, Zhao, Lili, Mobley, Harry L T, Bachman, Michael A

“…Klebsiella pneumoniae (Kp), one of the most common causes of healthcare-associated infections, increases patient morbidity, mortality, and hospitalization…”
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Bacterial Hyaluronidase Promotes Ascending GBS Infection and Preterm Birth by Vornhagen, Jay, Quach, Phoenicia, Boldenow, Erica, Merillat, Sean, Whidbey, Christopher, Ngo, Lisa Y, Adams Waldorf, K M, Rajagopal, Lakshmi

“…Preterm birth increases the risk of adverse birth outcomes and is the leading cause of neonatal mortality. A significant cause of preterm birth is in utero…”
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Combined comparative genomics and clinical modeling reveals plasmid-encoded genes are independently associated with Klebsiella infection by Vornhagen, Jay, Roberts, Emily K., Unverdorben, Lavinia, Mason, Sophia, Patel, Alieysa, Crawford, Ryan, Holmes, Caitlyn L., Sun, Yuang, Teodorescu, Alexandra, Snitkin, Evan S., Zhao, Lili, Simner, Patricia J., Tamma, Pranita D., Rao, Krishna, Kaye, Keith S., Bachman, Michael A.

“…Members of the Klebsiella pneumoniae species complex frequently colonize the gut and colonization is associated with subsequent infection. To identify genes…”
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A plasmid locus associated with Klebsiella clinical infections encodes a microbiome-dependent gut fitness factor by Vornhagen, Jay, Bassis, Christine M, Ramakrishnan, Srividya, Hein, Robert, Mason, Sophia, Bergman, Yehudit, Sunshine, Nicole, Fan, Yunfan, Holmes, Caitlyn L, Timp, Winston, Schatz, Michael C, Young, Vincent B, Simner, Patricia J, Bachman, Michael A

“…Klebsiella pneumoniae (Kp) is an important cause of healthcare-associated infections, which increases patient morbidity, mortality, and hospitalization costs…”
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Hyaluronidase Impairs Neutrophil Function and Promotes Group B Streptococcus Invasion and Preterm Labor in Nonhuman Primates by Coleman, Michelle, Armistead, Blair, Orvis, Austyn, Quach, Phoenicia, Brokaw, Alyssa, Gendrin, Claire, Sharma, Kavita, Ogle, Jason, Merillat, Sean, Dacanay, Matthew, Wu, Tsung-Yen, Munson, Jeff, Baldessari, Audrey, Vornhagen, Jay, Furuta, Anna, Nguyen, Shayla, Adams Waldorf, Kristina M, Rajagopal, Lakshmi

“…Invasive bacterial infections during pregnancy are a major risk factor for preterm birth, stillbirth, and fetal injury. Group B streptococci (GBS) are…”
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A streptococcal lipid toxin induces membrane permeabilization and pyroptosis leading to fetal injury by Whidbey, Christopher, Vornhagen, Jay, Gendrin, Claire, Boldenow, Erica, Samson, Jenny Mae, Doering, Kenji, Ngo, Lisa, Ezekwe, Ejiofor A D, Gundlach, Jens H, Elovitz, Michal A, Liggitt, Denny, Duncan, Joseph A, Adams Waldorf, Kristina M, Rajagopal, Lakshmi

“…Group B streptococci (GBS) are Gram‐positive bacteria that cause infections in utero and in newborns. We recently showed that the GBS pigment is hemolytic and…”
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Risk Factors for Klebsiella Infections among Hospitalized Patients with Preexisting Colonization by Rao, Krishna, Patel, Alieysa, Sun, Yuang, Vornhagen, Jay, Motyka, Jonathan, Collingwood, Abigail, Teodorescu, Alexandra, Baang, Ji Hoon, Zhao, Lili, Kaye, Keith S, Bachman, Michael A

“…Klebsiella commonly colonizes the intestinal tract of hospitalized patients and is a leading cause of health care-associated infections. Colonization is…”
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Coaggregation occurs amongst bacteria within and between biofilms in domestic showerheads by Vornhagen, Jay, Stevens, Michael, McCormick, David W., Dowd, Scot E., Eisenberg, Joseph N.S., Boles, Blaise R., Rickard, Alexander H.

“…Showerheads support the development of multi-species biofilms that can be unsightly, produce malodor, and may harbor pathogens. The outer-surface spray-plates…”
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Kinase Inhibitors that Increase the Sensitivity of Methicillin Resistant Staphylococcus aureus to β-Lactam Antibiotics by Vornhagen, Jay, Burnside, Kellie, Whidbey, Christopher, Berry, Jessica, Qin, Xuan, Rajagopal, Lakshmi

“…Staphylococcus aureus are Gram-positive bacteria that are the leading cause of recurrent infections in humans that include pneumonia, bacteremia,…”
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Mast cell degranulation by a hemolytic lipid toxin decreases GBS colonization and infection by Gendrin, Claire, Vornhagen, Jay, Ngo, Lisa, Whidbey, Christopher, Boldenow, Erica, Santana-Ufret, Veronica, Clauson, Morgan, Burnside, Kellie, Galloway, Dionne P, Adams Waldorf, Kristina M., Piliponsky, Adrian M, Rajagopal, Lakshmi

“…Ascending infection of microbes from the lower genital tract into the amniotic cavity increases the risk of preterm birth, stillbirth, and newborn infections…”
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Perinatal Group B Streptococcal Infections: Virulence Factors, Immunity, and Prevention Strategies by Vornhagen, Jay, Adams Waldorf, Kristina M, Rajagopal, Lakshmi

“…Group B streptococcus (GBS) or Streptococcus agalactiae is a β-hemolytic, Gram-positive bacterium that is a leading cause of neonatal infections. GBS commonly…”
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Fetal brain lesions after subcutaneous inoculation of Zika virus in a pregnant nonhuman primate by Adams Waldorf, Kristina M, Stencel-Baerenwald, Jennifer E, Kapur, Raj P, Studholme, Colin, Boldenow, Erica, Vornhagen, Jay, Baldessari, Audrey, Dighe, Manjiri K, Thiel, Jeff, Merillat, Sean, Armistead, Blair, Tisoncik-Go, Jennifer, Green, Richard R, Davis, Michael A, Dewey, Elyse C, Fairgrieve, Marian R, Gatenby, J Christopher, Richards, Todd, Garden, Gwenn A, Diamond, Michael S, Juul, Sandra E, Grant, Richard F, Kuller, LaRene, Shaw, Dennis W W, Ogle, Jason, Gough, G Michael, Lee, Wonsok, English, Chris, Hevner, Robert F, Dobyns, William B, Gale, Michael, Rajagopal, Lakshmi

“…New animal models of Zika virus (ZIKV) infection are imperative to accelerating efforts to treat or prevent disease in humans. Adams Waldorf et al . now report…”
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The Klebsiella pneumoniae ter Operon Enhances Stress Tolerance by Mason, Sophia, Vornhagen, Jay, Smith, Sara N, Mike, Laura A, Mobley, Harry L T, Bachman, Michael A

“…Healthcare-acquired infections are a leading cause of disease in patients that are hospitalized or in long-term-care facilities. Klebsiella pneumoniae (Kp) is…”
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Diminished Capsule Exacerbates Virulence, Blood–Brain Barrier Penetration, Intracellular Persistence, and Antibiotic Evasion of Hyperhemolytic Group B Streptococci by Gendrin, Claire, Merillat, Sean, Vornhagen, Jay, Coleman, Michelle, Armistead, Blair, Ngo, Lisa, Aggarwal, Anjali, Quach, Phoenicia, Berrigan, Jacob, Rajagopal, Lakshmi

“…Hyperhemolytic group B streptococci trade capsule for increased virulence, blood–brain barrier penetration, intracellular persistence, and antibiotic evasion…”
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Congenital Zika virus infection as a silent pathology with loss of neurogenic output in the fetal brain by Adams Waldorf, Kristina M, Nelson, Branden R, Stencel-Baerenwald, Jennifer E, Studholme, Colin, Kapur, Raj P, Armistead, Blair, Walker, Christie L, Merillat, Sean, Vornhagen, Jay, Tisoncik-Go, Jennifer, Baldessari, Audrey, Coleman, Michelle, Dighe, Manjiri K, Shaw, Dennis W W, Roby, Justin A, Santana-Ufret, Veronica, Boldenow, Erica, Li, Junwei, Gao, Xiaohu, Davis, Michael A, Swanstrom, Jesica A, Jensen, Kara, Widman, Douglas G, Baric, Ralph S, Medwid, Joseph T, Hanley, Kathryn A, Ogle, Jason, Gough, G Michael, Lee, Wonsok, English, Chris, Durning, W McIntyre, Thiel, Jeff, Gatenby, Chris, Dewey, Elyse C, Fairgrieve, Marian R, Hodge, Rebecca D, Grant, Richard F, Kuller, LaRene, Dobyns, William B, Hevner, Robert F, Gale, Michael, Rajagopal, Lakshmi

“…Zika virus infection of pregnant nonhuman primates results in the loss of fetal neuronal progenitor cells, even in the absence of overt microcephaly. Zika…”
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The ADP-Heptose Biosynthesis Enzyme GmhB is a Conserved Gram-Negative Bacteremia Fitness Factor by Holmes, Caitlyn L, Smith, Sara N, Gurczynski, Stephen J, Severin, Geoffrey B, Unverdorben, Lavinia V, Vornhagen, Jay, Mobley, Harry L T, Bachman, Michael A

“…Klebsiella pneumoniae is a leading cause of Gram-negative bacteremia, which is a major source of morbidity and mortality worldwide. Gram-negative bacteremia…”
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