Search Results - "Vora, Jayesh"

In vivo Target Modulation and Biological Activity of CHIR-258, a Multitargeted Growth Factor Receptor Kinase Inhibitor, in Colon Cancer Models by SANG HOON LEE, DE MENEZES, Daniel Lopes, HEISE, Carla, VORA, Jayesh, HARRIS, Alex, YE, Helen, NORDAHL, Lara, GARRETT, Evelyn, SAMARA, Emil, AUKERMAN, Sharon Lea, GELB, Arnold B

“…Purpose: To evaluate the therapeutic and biological effects of CHIR-258, an orally bioavailable, potent inhibitor of class III-V receptor tyrosine kinases, in…”
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Protective Effect of Butylated Hydroxyanisole on Adriamycin-induced Cardiotoxicity by Vora, Jayesh, Khaw, Ban-An, Narula, Jagat, Boroujerdi, Mehdi

“…Adriamycin has a wide spectrum of antitumour activity with dose‐related cardiotoxicity as a major side effect. This cardiotoxicity has been suggested to result…”
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Design, Structure−Activity Relationships and in Vivo Characterization of 4-Amino-3-benzimidazol-2-ylhydroquinolin-2-ones: A Novel Class of Receptor Tyrosine Kinase Inhibitors by Renhowe, Paul A, Pecchi, Sabina, Shafer, Cynthia M, Machajewski, Timothy D, Jazan, Elisa M, Taylor, Clarke, Antonios-McCrea, William, McBride, Christopher M, Frazier, Kelly, Wiesmann, Marion, Lapointe, Gena R, Feucht, Paul H, Warne, Robert L, Heise, Carla C, Menezes, Daniel, Aardalen, Kimberly, Ye, Helen, He, Molly, Le, Vincent, Vora, Jayesh, Jansen, Johanna M, Wernette-Hammond, Mary Ellen, Harris, Alex L

“…The inhibition of key receptor tyrosine kinases (RTKs) that are implicated in tumor vasculature formation and maintenance, as well as tumor progression and…”
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POM-001 Phase 1/2 Study of BMN 701, GILT-tagged Recombinant Human (rh) GAA in Late-Onset Pompe Disease: Preliminary Report by Byrne, Barry, Barshop, Bruce, Barohn, Richard, Falk, Lindsay, Fox, Michael, Lang, William, Lossius, Michelle, McCarthy, Sean, Vora, Jayesh, LeBowitz, Jonathon

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Design and structure–activity relationship of 3-benzimidazol-2-yl-1H-indazoles as inhibitors of receptor tyrosine kinases by McBride, Christopher M., Renhowe, Paul A., Heise, Carla, Jansen, Johanna M., Lapointe, Gena, Ma, Sylvia, Piñeda, Ramon, Vora, Jayesh, Wiesmann, Marion, Shafer, Cynthia M.

“…The synthesis and SAR of 3-benzimidazol-2-yl-1H-indazole analogs developed as inhibitors of receptor tyrosine kinases (RTK) is reported…”
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Design and structure–activity relationship of heterocyclic analogs of 4-amino-3-benzimidazol-2-ylhydroquinolin-2-ones as inhibitors of receptor tyrosine kinases by Frazier, Kelly, Jazan, Elisa, McBride, Christopher M., Pecchi, Sabina, Renhowe, Paul A., Shafer, Cynthia M., Taylor, Clarke, Bussiere, Dirksen, He, Molly Min, Jansen, Johanna M., Lapointe, Gena, Ma, Sylvia, Vora, Jayesh, Wiesmann, Marion

“…The synthesis and SAR of a series of novel heterocyclic analogs of the 4-amino-3-benzimidazol-2-ylhydroquinolin-2-one scaffold are reported. Herein are…”
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Pharmacokinetic-toxicodynamic Relationships of Adriamycin in Rat: Prediction of Butylated Hydroxyanisole-mediated Reduction in Anthracycline Cardiotoxicity by Vora, Jayesh, Boroujerdi, Mehdi

“…ABSTRACT Adriamycin, an anthracycline antibiotic, has broad antitumour activity with cumulative dose‐dependent cardiotoxicity as its major side effect. This…”
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Quantitation of acute experimental adriamycin cardiotoxicity by indium-111-labeled antimyosin fab by Vora, Jayesh, Boroujerdi, Mehdi, Narula, Jagat, Khaw, Ban-An

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Influence of dosing vehicles on the preclinical pharmacokinetics of phenolic antioxidants by Vora, J, Wu, Z, Montague, M, Penn, M, Erow, K

“…Phenolic antioxidants, such as butylated hydroxyanisole (BHA) and propyl gallate (PG), have demonstrated paradoxical cancer initiating and preventive actions…”
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