Search Results - "Voorman, Richard L."

Metabolic Aromatization of N-Alkyl-1,2,3,4-Tetrahydroquinoline Substructures to Quinolinium by Human Liver Microsomes and Horseradish Peroxidase by CHUNGANG GU, COLLINS, Roxane, HOLSWORTH, Daniel D, WALKER, Gregory S, VOORMAN, Richard L

“…Metabolic aromatization of xenobiotics is an unusual reaction with some documented examples. For instance, the oxidation of…”
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Prediction of clinical drug-drug interactions of veliparib (ABT-888) with human renal transporters (OAT1, OAT3, OCT2, MATE1, and MATE2K) by Kikuchi, Ryota, Lao, Yanbin, Bow, Daniel A J, Chiou, William J, Andracki, Mark E, Carr, Robert A, Voorman, Richard L, De Morais, Sonia M

“…Veliparib (ABT-888) is largely eliminated as parent drug in human urine (70% of the dose). Renal unbound clearance exceeds glomerular filtration rate,…”
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Parabens inhibit human skin estrogen sulfotransferase activity: Possible link to paraben estrogenic effects by Prusakiewicz, Jeffery J, Harville, Heather M, Zhang, Yanhua, Ackermann, Chrisita, Voorman, Richard L

“…Abstract Parabens ( p -hydroxybenzoate esters) are a group of widely used preservatives in topically applied cosmetic and pharmaceutical products. Parabens…”
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In vitro OATP1B1 and OATP1B3 inhibition is associated with observations of benign clinical unconjugated hyperbilirubinemia by Chiou, William J., de Morais, Sonia M., Kikuchi, Ryota, Voorman, Richard L., Li, Xiaofeng, Bow, Daniel A. J.

“…Abstract 1.  Transient benign unconjugated hyperbilirubinemia has been observed clinically with several drugs including indinavir, cyclosporine, and rifamycin…”
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Interaction of Delavirdine with Human Liver Microsomal Cytochrome P450: Inhibition of CYP2C9, CYP2C19, and CYP2D6 by VOORMAN, Richard L, PAYNE, N. Ann, WIENKERS, Larry C, HAUER, Michael J, SANDERS, Phillip E

“…Delavirdine, a non-nucleoside inhibitor of HIV-1 reverse transcriptase, is metabolized primarily through desalkylation catalyzed by CYP3A4 and CYP2D6 and by…”
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Development of in vitro methods to predict induction of CYP1A2 and CYP3A4 in humans by Grover, G Scott, Brayman, Timothy G, Voorman, Richard L, Ware, Joseph A

“…The important role of cytochrome P450 (CYP) drug-metabolizing enzymes has been studied for many years, and the potential liabilities of inducing these enzymes…”
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Metabolism of Delavirdine, a Human Immunodeficiency Virus Type-1 Reverse Transcriptase Inhibitor, by Microsomal Cytochrome P450 in Humans, Rats, and Other Species: Probable Involvement of CYP2D6 and CYP3A by VOORMAN, R. L, MAIO, S. M, HAUER, M. J, SANDERS, P. E, PAYNE, N. A, ACKLAND, M. J

“…The metabolism of delavirdine was examined using liver microsomes from several species with the aim of comparing metabolite formation among species and…”
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Synthesis and Bioactivity of Novel Bis(heteroaryl)piperazine (BHAP) Reverse Transcriptase Inhibitors:  Structure−Activity Relationships and Increased Metabolic Stability of Novel Substituted Pyridine Analogs by Genin, Michael J., Poel, Toni J., Yagi, Yoshihiko, Biles, Carolyn, Althaus, Irene, Keiser, Barbara J., Kopta, Laurice A., Friis, Jan M., Reusser, Fritz, Adams, Wade J., Voorman, Richard L., Thomas, Richard C., Romero, Donna L.

“…The major route of metabolism of the bis(heteroaryl)piperazine (BHAP) class of reverse transcriptase inhibitors (RTIs), atevirdine and delavirdine, is via…”
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Synthesis and Structure−Activity Relationships of the (Alkylamino)piperidine-Containing BHAP Class of Non-Nucleoside Reverse Transcriptase Inhibitors:  Effect of 3-Alkylpyridine Ring Substitution by Genin, Michael J, Poel, Toni J, May, Paul D, Kopta, Laurice A, Yagi, Yoshihiko, Olmsted, Robert A, Friis, Janice M, Voorman, Richard L, Adams, Wade J, Thomas, Richard C, Romero, Donna L

“…Development of resistance to currently approved HIV therapies has continued to fuel research efforts to improve the metabolic stability and spectrum of…”
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Microsomal metabolism of delavirdine: evidence for mechanism-based inactivation of human cytochrome P450 3A by Voorman, R L, Maio, S M, Payne, N A, Zhao, Z, Koeplinger, K A, Wang, X

“…Administration of delavirdine, an HIV-1 reverse transcriptase inhibitor, to rats or monkeys resulted in apparent loss of hepatic microsomal CYP3A and…”
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Discovery, Synthesis, and Bioactivity of Bis(heteroaryl)piperazines. 1. A Novel Class of Non-Nucleoside HIV-1 Reverse Transcriptase Inhibitors by Romero, Donna L, Morge, Raymond A, Biles, Carolyn, Berrios-Pena, Norman, May, Paul D, Palmer, John R, Johnson, Paul D, Smith, Herman W, Busso, Mariano, et. al

“…A variety of analogues of 1-[4-methoxy-3,5-dimethylbenzyl]-4-[3-(ethylamino)-2-pyridyl]piperazine hydrochloride (U-80493E) were synthesized and evaluated for…”
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Targeting Delavirdine/Atevirdine Resistant HIV-1:  Identification of (Alkylamino)piperidine-Containing Bis(heteroaryl)piperazines as Broad Spectrum HIV-1 Reverse Transcriptase Inhibitors by Romero, Donna L, Olmsted, Robert A, Poel, Toni Jo, Morge, Raymond A, Biles, Carolyn, Keiser, Barbara J, Kopta, Laurice A, Friis, Jan M, Hosley, John D, Stefanski, Kevin J, Wishka, Donn G, Evans, David B, Morris, Joel, Stehle, Randy G, Sharma, Satish K, Yagi, Yoshihiko, Voorman, Richard L, Adams, Wade J, Tarpley, W. Gary, Thomas, Richard C

“…A novel class of bis(heteroaryl)piperazine (BHAP) analogs which possesses the ability to inhibit NNRTI (non-nucleoside reverse transcriptase inhibitor)…”
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Identification of Dioxin-Responsive Genes in Hep G2 Cells Using Differential mRNA Display RT–PCR by Wang, Xiaohong, Harris, Peter K.W., Ulrich, Roger G., Voorman, Richard L.

“…Differential mRNA display RT–PCR (DD RT–PCR) offers a tool to identify genes which are regulated or responsive to certain receptors or chemicals such as dioxin…”
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Absorption, Distribution, Metabolism, and Excretion of Atevirdine in the Rat by CHANG, M, SOOD, V. K, WILSON, G. J, KLOOSTERMAN, D. A, SANDERS, P. E, SCHUETTE, M. R, JUDY, R. W, VOORMAN, R. L, MAIO, S. M, SLATTER, J. G

“…Atevirdine mesylate (U-87201E) is a highly specific nonnucleoside inhibitor of human immunodeficiency virus type 1 reverse transcriptase. The absorption,…”
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(−)-6-Chloro-2-[(1-furo[2,3-c]pyridin-5-ylethyl)thio]-4-pyrimidinamine, PNU-142721, a New Broad Spectrum HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitor by Wishka, Donn G, Graber, David R, Kopta, Laurice A, Olmsted, Robert A, Friis, Janice M, Hosley, John D, Adams, Wade J, Seest, Eric P, Castle, Thomas M, Dolak, Lester A, Keiser, Barbara J, Yagi, Yoshihiko, Jeganathan, Azhwarsamy, Schlachter, Stephen T, Murphy, Michael J, Cleek, Gary J, Nugent, Richard A, Poppe, Susan M, Swaney, Steven M, Han, Fusen, Watt, William, White, Wendy L, Poel, Toni-Jo, Thomas, Richard C, Voorman, Richard L, Stefanski, Kevin J, Stehle, Randall G, Tarpley, W. Gary, Morris, Joel

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