Search Results - "Voorde, Wouter"

A multimodal, comprehensive characterization of a cutaneous wound model in healthy volunteers by ten Voorde, Wouter, Saghari, Mahdi, Boltjes, Jiry, de Kam, Marieke L., Zhuparris, Ahnjili, Feiss, Gary, Buters, Thomas P., Prens, Errol P., Damman, Jeffrey, Niemeyer‐van der Kolk, Tessa, Moerland, Matthijs, Burggraaf, Jacobus, van Doorn, Martijn B. A., Rissmann, Robert

“…Development of pharmacological interventions for wound treatment is challenging due to both poorly understood wound healing mechanisms and heterogeneous…”
Get full text

Comprehensive evaluation of microneedle‐based intradermal adalimumab delivery vs. subcutaneous administration: results of a randomized controlled clinical trial by Jacobse, Justin, Voorde, Wouter, Tandon, Anushka, Romeijn, Stefan G., Grievink, Hendrika W., Maaden, Koen, Esdonk, Michiel J., Moes, Dirk Jan A.R., Loeff, Floris, Bloem, Karien, Vries, Annick, Rispens, Theo, Wolbink, Gertjan, Kam, Marieke, Ziagkos, Dimitrios, Moerland, Matthijs, Jiskoot, Wim, Bouwstra, Joke, Burggraaf, Jacobus, Schrier, Lenneke, Rissmann, Robert, Cate, Rebecca

“…Aims To evaluate feasibility of intradermal (i.d.) adalimumab administration using hollow microneedles, and to compare a single i.d. dose of adalimumab using a…”
Get full text

Intradermal lipopolysaccharide challenge as an acute in vivo inflammatory model in healthy volunteers by Buters, Thomas P., Hameeteman, Pieter W., Jansen, Iris M. E., Hindevoort, Floris C., Voorde, Wouter, Florencia, Edwin, Osse, Michelle, Kam, Marieke L., Grievink, Hendrika W., Schoonakker, Mascha, Patel, Amit A., Yona, Simon, Gilroy, Derek W., Lubberts, Erik, Damman, Jeffrey, Feiss, Gary, Rissmann, Robert, Jansen, Manon A. A., Burggraaf, Jacobus, Moerland, Matthijs

“…Aims Whereas intravenous administration of Toll‐like receptor 4 ligand lipopolysaccharide (LPS) to human volunteers is frequently used in clinical pharmacology…”
Get full text

The oral IRAK4 inhibitors zabedosertib and BAY1830839 suppress local and systemic immune responses in a randomized trial in healthy male volunteers by Jodl, Stefan J., Voorde, Wouter, Klein, Stefan, Wagenfeld, Andrea, Zollmann, Frank S., Feldmüller, Maximilian, Klarenbeek, Naomi B., Bruin, Digna T., Jansen, Manon A. A., Rissmann, Robert, Rohde, Beate, Moerland, Matthijs

“…This study evaluated and characterized the pharmacological activity of the orally administered interleukin‐1 receptor‐associated kinase 4 (IRAK4) inhibitors…”
Get full text

The effect of repeated methotrexate injections on the quality of life of children with rheumatic diseases by Jacobse, Justin, ten Voorde, Wouter, Rissmann, Robert, Burggraaf, Jacobus, ten Cate, Rebecca, Schrier, Lenneke

“…In clinical practice, the burden of repeated injections in children with rheumatic disease receiving disease-modifying anti-rheumatic drugs is significant. To…”
Get full text

Intradermal substance P as a challenge agent in healthy individuals by Ten Voorde, Wouter, Akinseye, Chika, Abdisalaam, Ismahaan, Wind, Selinde, Klarenbeek, Naomi, Bergmans, Menthe, van Doorn, Martijn, Rissmann, Robert, Kaur, Rejbinder, Hotee, Sarah, Foster, Katie, Nair, Arati, Fortunato, Lea, Macphee, Colin, Mole, Sarah, Baumann, Katrine, Brigandi, Richard

“…Pharmacological challenge models are deployed to evaluate drug effects during clinical development. Intradermal injection of Substance P (SP) neuropeptide, a…”
Get full text

A suction blister model to characterize epidermal wound healing and evaluate the efficacy of the topical wound healing agent INM-755 in healthy volunteers by Voorde, Wouter ten, Wind, Selinde, Abdisalaam, Ismahaan, Mancini, Alexandra, Linders, Feeke, Jansen, Manon A.A, Kolk, Tessa Niemeyer-van der, Burggraaf, Jacobus, Rissmann, Robert

“…Non-healing wounds represent a substantial medical burden with few effective treatments available. To address this challenge, we developed a novel epidermal…”
Get full text

Needle-free jet injector treatment with bleomycin is efficacious in patients with severe keloids: a randomized, double-blind, placebo-controlled trial by Bekkers, Vazula Z, Zdunczyk, Katarzyna M, Bik, Liora, Ten Voorde, Wouter, Aarts, Pim, Oerlemans, Femke, Bohoslavsky, Roman, Haedersdal, Merete, Prens, Errol P, Rissmann, Robert, van Doorn, Martijn B A

“…Severe keloids are difficult to treat. Corticosteroid injections with needles are painful and associated with frequent recurrences. Therefore, more effective,…”
Get full text

Clinical, Cellular, and Molecular Effects of Corticosteroids on the Response to Intradermal Lipopolysaccharide Administration in Healthy Volunteers by Buters, Thomas P., Hameeteman, Pieter W., Jansen, Iris M.E., Hindevoort, Floris C., ten Voorde, Wouter, Grievink, Hendrika W., Schoonakker, Mascha, Kam, Marieke L., Gilroy, Derek W., Feiss, Gary, Rissmann, Robert, Jansen, Manon A.A., Burggraaf, Jacobus, Moerland, Matthijs

“…The intradermal lipopolysaccharide (LPS) challenge in healthy volunteers has proven to be a valuable tool to study local inflammation in vivo. In the current…”
Get full text

Dermatoscopy and Optical Coherence Tomography in Vulvar High-Grade Squamous Intraepithelial Lesions and Lichen Sclerosus: A Prospective Observational Trial by Huisman, Bertine W., Pagan, Lisa, Naafs, Rosanne G.C., ten Voorde, Wouter, Rissmann, Robert, Piek, Jurgen M.J., Damman, Jeffrey, Juachon, Maria J., Osse, Michelle, Niemeyer-van der Kolk, Tessa, van Hees, Colette L.M., van Poelgeest, Mariette I.E.

Get full text

Dermatoscopy and Optical Coherence Tomography in Vulvar High-Grade Squamous Intraepithelial Lesions and Lichen Sclerosus: A Prospective Observational Trial by Huisman, Bertine W., Pagan, Lisa, Naafs, Rosanne G.C., ten Voorde, Wouter, Rissmann, Robert, Piek, Jurgen M.J., Damman, Jeffrey, Juachon, Maria J., Osse, Michelle, Niemeyer-van der Kolk, Tessa, van Hees, Colette L.M., van Poelgeest, Mariette I.E.

“…This study aimed to examine potential discriminatory characteristics of dermatoscopy and dynamic optical coherence tomography (D-OCT) on vulvar high-grade…”
Get full text