Different transformation pathways of murine fibroblast NIH 3T3 cells by hepatitis C virus core and NS3 proteins

Different transformation pathways of murine fibroblast NIH 3T3 cells by hepatitis C virus core and NS3 proteins

The oncogenic potential of both Hepatitis C virus (HCV) core and HCV NS3 proteins has been demonstrated, but these proteins induce transformation of immortal murine fibroblasts NIH 3T3 via different pathways. As long-term expression (50–100 passages) of HCV core triggers neoplastic transformation of...

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Bibliographic Details
Published in:Cell biology international Vol. 30; no. 11; pp. 915 - 919
Main Authors: Smirnova, Irina S., Aksenov, Nikolai D., Vonsky, Maksim S., Isaguliants, Maria G.
Format: Journal Article
Language:English
Published: Oxford, UK Elsevier Ltd 01-11-2006
Blackwell Publishing Ltd
Subjects:
Animals
Cell Line, Transformed
Cell transformation
Clone Cells
Core
Fibroblasts - cytology
G1 Phase
G2 Phase
HCV
Hepacivirus - metabolism
Mice
Mitosis
NIH 3T3 Cells
NS3
p53
Resting Phase, Cell Cycle
Transcriptional Activation
Transfection
Tumor Suppressor Protein p53 - genetics
Viral Core Proteins - metabolism
Viral Nonstructural Proteins - metabolism
HCV
Cell transformation
Core
NS3
p53
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Summary:The oncogenic potential of both Hepatitis C virus (HCV) core and HCV NS3 proteins has been demonstrated, but these proteins induce transformation of immortal murine fibroblasts NIH 3T3 via different pathways. As long-term expression (50–100 passages) of HCV core triggers neoplastic transformation of NIH 3T3 through crisis of growth, HCV NS3 induces transformation shortly after transfection. We explain this distinction by different effects of core and NS3 on p53-mediated transactivation: inhibition by NS3 and activation by core protein.
Bibliography:ark:/67375/WNG-DFCBTJ7W-P
ArticleID:CBIN2391
istex:5AAB27A19C37782E5A34E3088F12F753C7537457
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1065-6995
1095-8355
DOI:10.1016/j.cellbi.2006.06.020