Search Results - "Vonk, JM"
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Responsivity and Reproducibility of Sputum Inflammatory Biomarkers During COPD Exacerbation and Stable Phases - A Pilot Study
Published in International journal of chronic obstructive pulmonary disease (01-01-2021)“…There is a great interest to identify airway biomarkers to evaluate the potential and efficacy of anti-inflammatory therapeutic interventions. In this pilot…”
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Shared genetic origin of asthma, hay fever and eczema elucidates allergic disease biology
Published in Nature genetics (01-12-2017)“…This large-scale genome-wide association analysis of subjects with asthma, hay fever or eczema provides insights into the shared genetic basis of these…”
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3
Genetic Architectures of Childhood- and Adult-Onset Asthma Are Partly Distinct
Published in American journal of human genetics (04-04-2019)“…The extent to which genetic risk factors are shared between childhood-onset (COA) and adult-onset (AOA) asthma has not been estimated. On the basis of data…”
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Maternal BMI at the start of pregnancy and offspring epigenome-wide DNA methylation: findings from the pregnancy and childhood epigenetics (PACE) consortium
Published in Human molecular genetics (15-10-2017)“…Pre-pregnancy maternal obesity is associated with adverse offspring outcomes at birth and later in life. Individual studies have shown that epigenetic…”
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Plasticity of Individual Lung Function States from Childhood to Adulthood
Published in American journal of respiratory and critical care medicine (15-02-2023)“…Recent evidence highlights the importance of optimal lung development during childhood for health throughout life. To explore the plasticity of individual lung…”
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Genome-Wide Interaction Analysis of Air Pollution Exposure and Childhood Asthma with Functional Follow-up
Published in American journal of respiratory and critical care medicine (15-05-2017)“…The evidence supporting an association between traffic-related air pollution exposure and incident childhood asthma is inconsistent and may depend on genetic…”
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Epigenome-wide meta-analysis of blood DNA methylation in newborns and children identifies numerous loci related to gestational age
Published in Genome medicine (02-03-2020)“…Preterm birth and shorter duration of pregnancy are associated with increased morbidity in neonatal and later life. As the epigenome is known to have an…”
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Eleven loci with new reproducible genetic associations with allergic disease risk
Published in Journal of allergy and clinical immunology (01-02-2019)“…A recent genome-wide association study (GWAS) identified 99 loci that contain genetic risk variants shared between asthma, hay fever, and eczema. Many more…”
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Respiratory effects of sulphur dioxide: a hierarchical multicity analysis in the APHEA 2 study
Published in Occupational and environmental medicine (London, England) (01-08-2003)“…Background: Sulphur dioxide (SO2) was associated with hospital admissions for asthma in children in the original APHEA study, but not with other respiratory…”
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Air pollution and IgE sensitization in 4 European birth cohorts—the MeDALL project
Published in Journal of allergy and clinical immunology (01-02-2021)“…Whether long-term exposure air to pollution has effects on allergic sensitization is controversial. Our aim was to investigate associations of air pollution…”
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Ambient ultrafine particles and asthma onset until age 20: The PIAMA birth cohort
Published in Environmental research (01-11-2022)“…Evidence regarding the role of long-term exposure to ultrafine particles (<0.1 μm, UFP) in asthma onset is scarce. We examined the association between exposure…”
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Genetic risk scores do not improve asthma prediction in childhood
Published in Journal of allergy and clinical immunology (01-09-2019)“…[...]the SHARE consortium discovered 136 independent genetic variants to be associated with allergic disease (asthma, hay fever, or eczema) in 360,000…”
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Rare variant analysis in eczema identifies exonic variants in DUSP1, NOTCH4 and SLC9A4
Published in Nature communications (16-11-2021)“…Previous genome-wide association studies revealed multiple common variants involved in eczema but the role of rare variants remains to be elucidated. Here, we…”
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Shared DNA methylation signatures in childhood allergy: The MeDALL study
Published in Journal of allergy and clinical immunology (01-03-2021)“…Differential DNA methylation associated with allergy might provide novel insights into the shared or unique etiology of asthma, rhinitis, and eczema. We sought…”
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Predictors and associations of the persistent airflow limitation phenotype in asthma: a post-hoc analysis of the ATLANTIS study
Published in The lancet respiratory medicine (01-01-2023)“…Persistent airflow limitation (PAL) occurs in a subset of patients with asthma. Previous studies on PAL in asthma have included relatively small populations,…”
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DNA methylation and body mass index from birth to adolescence: meta-analyses of epigenome-wide association studies
Published in Genome medicine (25-11-2020)“…DNA methylation has been shown to be associated with adiposity in adulthood. However, whether similar DNA methylation patterns are associated with childhood…”
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Age-of-onset information helps identify 76 genetic variants associated with allergic disease
Published in PLoS genetics (30-06-2020)“…Risk factors that contribute to inter-individual differences in the age-of-onset of allergic diseases are poorly understood. The aim of this study was to…”
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Acute Effects of Ozone on Mortality from the "Air Pollution and Health: A European Approach" Project
Published in American journal of respiratory and critical care medicine (15-11-2004)“…In the Air Pollution and Health: A European Approach (APHEA2) project, the effects of ambient ozone concentrations on mortality were investigated. Data were…”
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Epigenome-wide meta-analysis of DNA methylation and childhood asthma
Published in Journal of allergy and clinical immunology (01-06-2019)“…Epigenetic mechanisms, including methylation, can contribute to childhood asthma. Identifying DNA methylation profiles in asthmatic patients can inform disease…”
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Estimating the Exposure-Response Relationships between Particulate Matter and Mortality within the APHEA Multicity Project
Published in Environmental health perspectives (01-01-2005)“…Several studies have reported significant health effects of air pollution even at low levels of air pollutants, but in most of theses studies linear…”
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