Search Results - "Vongsouthi, Vanessa"

Structural and evolutionary approaches to the design and optimization of fluorescence-based small molecule biosensors by Kaczmarski, Joe A, Mitchell, Joshua A, Spence, Matthew A, Vongsouthi, Vanessa, Jackson, Colin J

“…[Display omitted] •Designing genetically encoded fluorescence-based analyte biosensors is not trivial.•Many current design efforts take a nature-inspired,…”
Get full text

Ancestral Sequence Reconstruction Identifies Structural Changes Underlying the Evolution of Ideonella sakaiensis PETase and Variants with Improved Stability and Activity by Joho, Yvonne, Vongsouthi, Vanessa, Spence, Matthew A., Ton, Jennifer, Gomez, Chloe, Tan, Li Lynn, Kaczmarski, Joe A., Caputo, Alessandro T., Royan, Santana, Jackson, Colin J., Ardevol, Albert

“…The improved production, recycling, and removal of plastic waste, such as polyethylene terephthalate (PET), are pressing environmental and economic issues for…”
Get full text

Improving plastic degrading enzymes via directed evolution by Joho, Yvonne, Vongsouthi, Vanessa, Gomez, Chloe, Larsen, Joachim S, Ardevol, Albert, Jackson, Colin J

“…Abstract Plastic degrading enzymes have immense potential for use in industrial applications. Protein engineering efforts over the last decade have resulted in…”
Get full text

Monitoring hippocampal glycine with the computationally designed optical sensor GlyFS by Zhang, William H., Herde, Michel K., Mitchell, Joshua A., Whitfield, Jason H., Wulff, Andreas B., Vongsouthi, Vanessa, Sanchez-Romero, Inmaculada, Gulakova, Polina E., Minge, Daniel, Breithausen, Björn, Schoch, Susanne, Janovjak, Harald, Jackson, Colin J., Henneberger, Christian

“…Fluorescent sensors are an essential part of the experimental toolbox of the life sciences, where they are used ubiquitously to visualize intra- and…”
Get full text

Increasing the Soluble Expression and Whole-Cell Activity of the Plastic-Degrading Enzyme MHETase through Consensus Design by Saunders, Jake W., Damry, Adam M., Vongsouthi, Vanessa, Spence, Matthew A., Frkic, Rebecca L., Gomez, Chloe, Yates, Patrick A., Matthews, Dana S., Tokuriki, Nobuhiko, McLeod, Malcolm D., Jackson, Colin J.

“…The mono­(2-hydroxyethyl) terephthalate hydrolase (MHETase) from Ideonella sakaiensis carries out the second step in the enzymatic depolymerization of…”
Get full text

An increased copy number of glycine decarboxylase (GLDC) associated with psychosis reduces extracellular glycine and impairs NMDA receptor function by Kambali, Maltesh, Li, Yan, Unichenko, Petr, Feria Pliego, Jessica A, Yadav, Rachita, Liu, Jing, McGuinness, Patrick, Cobb, Johanna G, Wang, Muxiao, Nagarajan, Rajasekar, Lyu, Jinrui, Vongsouthi, Vanessa, Jackson, Colin J, Engin, Elif, Coyle, Joseph T, Shin, Jaeweon, Hodgson, Nathaniel W, Hensch, Takao K, Talkowski, Michael E, Homanics, Gregg E, Bolshakov, Vadim Y, Henneberger, Christian, Rudolph, Uwe

“…Glycine is an obligatory co-agonist at excitatory NMDA receptors in the brain, especially in the dentate gyrus, which has been postulated to be crucial for the…”
Get full text

A Rationally and Computationally Designed Fluorescent Biosensor for d‑Serine by Vongsouthi, Vanessa, Whitfield, Jason H, Unichenko, Petr, Mitchell, Joshua A, Breithausen, Björn, Khersonsky, Olga, Kremers, Leon, Janovjak, Harald, Monai, Hiromu, Hirase, Hajime, Fleishman, Sarel J, Henneberger, Christian, Jackson, Colin J

“…Solute-binding proteins (SBPs) have evolved to balance the demands of ligand affinity, thermostability, and conformational change to accomplish diverse…”
Get full text