Search Results - "Von Seggern, D J"

Signaling antibodies complexed with adenovirus circumvent CAR and integrin interactions and improve gene delivery by LI, E, BROWN, S. L, VON SEGGERN, D. J, BROWN, G. B, NEMEROW, G. R

“…Current adenoviral (Ad) vectors cannot be targeted to specific cell types due to the widespread distribution of the Ad receptor (CAR). Moreover, CAR and/or…”
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Adenovirus Type 5 Viral Particles Pseudotyped with Mutagenized Fiber Proteins Show Diminished Infectivity of Coxsackie B-Adenovirus Receptor-Bearing Cells by Jakubczak, J L, Rollence, M L, Stewart, D A, Jafari, J D, Von Seggern, D J, Nemerow, G R, Stevenson, S C, Hallenbeck, P L

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Inhibition of Radiation Cataractogenesis by WR-77913 by Livesey, J. C., Wiens, L. W., Von Seggern, D. J., Barlow, W. E., Arnold, A. M.

“…The radioprotective drug S-3-amino-2-hydroxypropylphosphorothioic acid (WR-77913) has been tested as an inhibitor of radiation cataractogenesis. Animals…”
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Ablating Adenovirus Type 5 Fiber–CAR Binding and HI Loop Insertion of the SIGYPLP Peptide Generate an Endothelial Cell-Selective Adenovirus by Nicklin, Stuart A., Von Seggern, Dan J., Work, Lorraine M., Pek, Don C.K., Dominiczak, Anna F., Nemerow, Glen R., Baker, Andrew H.

“…Adenovirus type 5 (Ad) based vectors transduce vascular endothelial cells (EC) and have been widely used for vascular gene transfer. However, many cell types…”
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Adenovirus Vector Pseudotyping in Fiber-Expressing Cell Lines: Improved Transduction of Epstein-Barr Virus-Transformed B Cells by Von Seggern, D J, Huang, S, Fleck, S K, Stevenson, S C, Nemerow, G R

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A Helper-Independent Adenovirus Vector with E1, E3, and Fiber Deleted: Structure and Infectivity of Fiberless Particles by Von Seggern, D J, Chiu, C Y, Fleck, S K, Stewart, P L, Nemerow, G R

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Structural Analysis of a Fiber-Pseudotyped Adenovirus with Ocular Tropism Suggests Differential Modes of Cell Receptor Interactions by Chiu, C Y, Wu, E, Brown, S L, Von Seggern, D J, Nemerow, G R, Stewart, P L

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Complementation of a fibre mutant adenovirus by packaging cell lines stably expressing the adenovirus type 5 fibre protein by Von Seggern, DJ, Kehler, J, Endo, RI, Nemerow, GR

“…DJ Von Seggern, J Kehler, RI Endo and GR Nemerow Department of Immunology, The Scripps Research Institute, La Jolla, CA 92037, USA. Adenovirus-based gene…”
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A 50-kDa Membrane Protein Mediates Sialic Acid-Independent Binding and Infection of Conjunctival Cells by Adenovirus Type 37 by Wu, Eugene, Fernandez, Joan, Fleck, Shonna Kaye, Von Seggern, Dan J., Huang, Shuang, Nemerow, Glen R.

“…The ocular tropism of adenovirus type 37 (Ad37) does not correlate with the wide distribution of the 46-kDa coxsackievirus and adenovirus receptor (CAR), the…”
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Membrane Cofactor Protein Is a Receptor for Adenoviruses Associated with Epidemic Keratoconjunctivitis by WU, Eugene, TRAUGER, Sunia A, PACHE, Lars, MULLEN, Tina-Marie, VON SEGGERN, Daniel J, SIUZDAK, Gary, NEMEROW, Glen R

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Flexibility of the Adenovirus Fiber Is Required for Efficient Receptor Interaction by Wu, Eugene, Pache, Lars, Von Seggern, Dan J, Mullen, Tina-Marie, Mikyas, Yeshi, Stewart, Phoebe L, Nemerow, Glen R

“…Erratum ( vol. 78 , p. 2167 ) Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious…”
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Development of Efficient Viral Vectors Selective for Vascular Smooth Muscle Cells by Work, Lorraine M, Nicklin, Stuart A, Brain, Nick J.R, Dishart, Kate L, Von Seggern, Dan J, Hallek, Michael, Büning, Hildegard, Baker, Andrew H

“…The vascular smooth muscle cell (SMC) is integral to the pathogenesis of neointimal formation associated with late vein graft failure, in-stent restenosis, and…”
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Adenoviral serotype 5 vectors pseudotyped with fibers from subgroup D show modified tropism in vitro and in vivo by Denby, Laura, Work, Lorraine M, Graham, Delyth, Hsu, Catherine, von Seggern, Dan J, Nicklin, Stuart A, Baker, Andrew H

“…Adenovirus (Ad5) serotype 5 vectors are commonly used for gene transfer. Preclinical studies have shown that their application to systemic gene delivery,…”
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In vitro and in vivo characterisation of endothelial cell selective adenoviral vectors by Nicklin, Stuart A., White, Steve J., Nicol, Campbell G., Von Seggern, Dan J., Baker, Andrew H.

“…Background Both viral and non‐viral gene transfer vectors transduce vascular endothelial cells (EC) with low efficiency compared with other cell types such as…”
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In vitro dendritic cell infection by pseudotyped adenoviral vectors does not correlate with their in vivo immunogenicity by Hsu, Catherine, Boysen, Megan, Gritton, Lance D., Frosst, Phyllis D., Nemerow, Glen R., Von Seggern, Dan J.

“…Expression of antigens in dendritic cells (DC) can stimulate protective immunity against both viral infection and tumor growth, making them important targets…”
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Transductional and transcriptional targeting of cancer cells using genetically engineered viral vectors by Nicklin, Stuart A., Dishart, Kate L., Buening, Hildegard, Reynolds, Paul N., Hallek, Michael, Nemerow, Glen R., Von Seggern, Dan J., Baker, Andrew H.

“…Gene delivery vectors, including adenovirus (Ad) and adeno-associated virus (AAV), are inefficient and non-selective for cancer due to low levels of viral…”
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In vivo transduction of photoreceptors or ciliary body by intravitreal injection of pseudotyped adenoviral vectors by Von Seggern, Dan J, Aguilar, Edith, Kinder, Karen, Fleck, Shonna Kaye, Gonzalez Armas, J.C, Stevenson, Susan C, Ghazal, Peter, Nemerow, Glen R, Friedlander, Martin

“…Strategies for retargeting adenoviral (Ad) vectors have been developed, but their in vivo efficacy remains to be demonstrated. Gene delivery to specific ocular…”
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Flexibility of the Adenovirus Fiber Is Required for Efficient Receptor Interaction by Wu, Eugene, Pache, Lars, Von Seggern, Dan J., Mullen, Tina-Marie, Mikyas, Yeshi, Stewart, Phoebe L., Nemerow, Glen R.

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