Search Results - "Von Moltke, Jakob"

The Immune Function of Tuft Cells at Gut Mucosal Surfaces and Beyond by Ting, Hung-An, von Moltke, Jakob

“…Tuft cells were first discovered in epithelial barriers decades ago, but their function remained unclear until recently. In the last 2 years, a series of…”
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MicroRNA regulation of type 2 innate lymphoid cell homeostasis and function in allergic inflammation by Singh, Priti B, Pua, Heather H, Happ, Hannah C, Schneider, Christoph, von Moltke, Jakob, Locksley, Richard M, Baumjohann, Dirk, Ansel, K Mark

“…MicroRNAs (miRNAs) exert powerful effects on immunity through coordinate regulation of multiple target genes in a wide variety of cells. Type 2 innate lymphoid…”
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Thymic tuft cells promote an IL-4-enriched medulla and shape thymocyte development by Miller, Corey N., Proekt, Irina, von Moltke, Jakob, Wells, Kristen L., Rajpurkar, Aparna R., Wang, Haiguang, Rattay, Kristin, Khan, Imran S., Metzger, Todd C., Pollack, Joshua L., Fries, Adam C., Lwin, Wint W., Wigton, Eric J., Parent, Audrey V., Kyewski, Bruno, Erle, David J., Hogquist, Kristin A., Steinmetz, Lars M., Locksley, Richard M., Anderson, Mark S.

“…The thymus is responsible for generating a diverse yet self-tolerant pool of T cells 1 . Although the thymic medulla consists mostly of developing and mature…”
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Injury-induced pulmonary tuft cells are heterogenous, arise independent of key Type 2 cytokines, and are dispensable for dysplastic repair by Barr, Justinn, Gentile, Maria Elena, Lee, Sunyoung, Kotas, Maya E, Fernanda de Mello Costa, Maria, Holcomb, Nicolas P, Jaquish, Abigail, Palashikar, Gargi, Soewignjo, Marcella, McDaniel, Margaret, Matsumoto, Ichiro, Margolskee, Robert, Von Moltke, Jakob, Cohen, Noam A, Sun, Xin, Vaughan, Andrew E

“…While the lung bears significant regenerative capacity, severe viral pneumonia can chronically impair lung function by triggering dysplastic remodeling. The…”
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Sentinels of the Type 2 Immune Response by von Moltke, Jakob, Pepper, Marion

“…Type 2 immune responses have evolved to sense and respond to large, non-replicating infections or non-microbial noxious compounds in tissues. The development…”
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NAIP-NLRC4 Inflammasomes Coordinate Intestinal Epithelial Cell Expulsion with Eicosanoid and IL-18 Release via Activation of Caspase-1 and -8 by Rauch, Isabella, Deets, Katherine A., Ji, Daisy X., von Moltke, Jakob, Tenthorey, Jeannette L., Lee, Angus Y., Philip, Naomi H., Ayres, Janelle S., Brodsky, Igor E., Gronert, Karsten, Vance, Russell E.

“…Intestinal epithelial cells (IECs) form a critical barrier against pathogen invasion. By generation of mice in which inflammasome expression is restricted to…”
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Differential Activation of the Transcription Factor IRF1 Underlies the Distinct Immune Responses Elicited by Type I and Type III Interferons by Forero, Adriana, Ozarkar, Snehal, Li, Hongchuan, Lee, Chia Heng, Hemann, Emily A., Nadjsombati, Marija S., Hendricks, Matthew R., So, Lomon, Green, Richard, Roy, Chandra N., Sarkar, Saumendra N., von Moltke, Jakob, Anderson, Stephen K., Gale, Michael, Savan, Ram

“…Type I and III interferons (IFNs) activate similar downstream signaling cascades, but unlike type I IFNs, type III IFNs (IFNλ) do not elicit strong…”
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Tuning tuft cells: new ligands and effector functions reveal tissue-specific function by Billipp, Tyler E, Nadjsombati, Marija S, von Moltke, Jakob

“…•Tuft cells reside in the epithelium of airway, intestinal, and urogenital tissues.•Tuft cell receptors and effector functions are tuned in a tissue-specific…”
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TSLP, IL-33, and IL-25: Not just for allergy and helminth infection by Stanbery, Alison G., Shuchi Smita, Jakob von Moltke, Tait Wojno, Elia D., Ziegler, Steven F.

“…The release of cytokines from epithelial and stromal cells is critical for the initiation and maintenance of tissue immunity. Three such cytokines, thymic…”
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Detection of Succinate by Intestinal Tuft Cells Triggers a Type 2 Innate Immune Circuit by Nadjsombati, Marija S., McGinty, John W., Lyons-Cohen, Miranda R., Jaffe, James B., DiPeso, Lucian, Schneider, Christoph, Miller, Corey N., Pollack, Joshua L., Nagana Gowda, G.A., Fontana, Mary F., Erle, David J., Anderson, Mark S., Locksley, Richard M., Raftery, Daniel, von Moltke, Jakob

“…In the small intestine, type 2 responses are regulated by a signaling circuit that involves tuft cells and group 2 innate lymphoid cells (ILC2s). Here, we…”
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Differential requirement for Caspase-1 autoproteolysis in pathogen-induced cell death and cytokine processing by Broz, Petr, von Moltke, Jakob, Jones, Jonathan W, Vance, Russell E, Monack, Denise M

“…Activation of the cysteine protease Caspase-1 is a key event in the innate immune response to infections. Synthesized as a proprotein, Caspase-1 undergoes…”
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Recognition of Bacteria by Inflammasomes by von Moltke, Jakob, Ayres, Janelle S, Kofoed, Eric M, Chavarría-Smith, Joseph, Vance, Russell E

“…Inflammasomes are cytosolic multiprotein complexes that assemble in response to a variety of infectious and noxious insults. Inflammasomes play a critical role…”
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Leukotrienes provide an NFAT-dependent signal that synergizes with IL-33 to activate ILC2s by von Moltke, Jakob, O'Leary, Claire E, Barrett, Nora A, Kanaoka, Yoshihide, Austen, K Frank, Locksley, Richard M

“…Group 2 innate lymphoid cells (ILC2s) and type 2 helper T cells (Th2 cells) are the primary source of interleukin 5 (IL-5) and IL-13 during type 2 (allergic)…”
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Rapid induction of inflammatory lipid mediators by the inflammasome in vivo by von Moltke, Jakob, Trinidad, Norver J., Moayeri, Mahtab, Kintzer, Alexander F., Wang, Samantha B., van Rooijen, Nico, Brown, Charles R., Krantz, Bryan A., Leppla, Stephen H., Gronert, Karsten, Vance, Russell E.

“…Induction of an eicosanoid storm is shown to be an unexpected consequence of inflammasome activation in peritoneal macrophages, leading to vascular leakage and…”
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N-Ethyl-N-Nitrosourea-Induced Goldenticket Mouse Mutant Reveals an Essential Function of Sting in the In Vivo Interferon Response to Listeria monocytogenes and Cyclic Dinucleotides by Sauer, John-Demian, Sotelo-Troha, Katia, von Moltke, Jakob, Monroe, Kathryn M, Rae, Chris S, Brubaker, Sky W, Hyodo, Mamoru, Hayakawa, Yoshihiro, Woodward, Joshua J, Portnoy, Daniel A, Vance, Russell E

“…Type I interferons (IFNs) are central regulators of the innate and adaptive immune responses to viral and bacterial infections. Type I IFNs are induced upon…”
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CIRCling the wagons to protect intestinal stem cells by Soveg, Frank, von Moltke, Jakob, Savan, Ram

“…Innate lymphoid cell–derived cytokine IL-13 promotes the maintenance of intestinal stem cells through stabilization of β-catenin. The circular RNA circPan3…”
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NAIP/NLRC4 inflammasome activation in MRP8+ cells is sufficient to cause systemic inflammatory disease by Nichols, Randilea D., von Moltke, Jakob, Vance, Russell E.

“…Inflammasomes are cytosolic multiprotein complexes that initiate protective immunity in response to infection, and can also drive auto-inflammatory diseases,…”
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Tuft cell-derived acetylcholine promotes epithelial chloride secretion and intestinal helminth clearance by Billipp, Tyler E, Fung, Connie, Webeck, Lily M, Sargent, Derek B, Gologorsky, Matthew B, Chen, Zuojia, McDaniel, Margaret M, Kasal, Darshan N, McGinty, John W, Barrow, Kaitlyn A, Rich, Lucille M, Barilli, Alessio, Sabat, Mark, Debley, Jason S, Wu, Chuan, Myers, Richard, Howitt, Michael R, von Moltke, Jakob

“…Epithelial cells secrete chloride to regulate water release at mucosal barriers, supporting both homeostatic hydration and the "weep" response that is critical…”
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Critical function for Naip5 in inflammasome activation by a conserved carboxy-terminal domain of flagellin by Vance, Russell E, Lightfield, Karla L, Persson, Jenny, Brubaker, Sky W, Dunipace, Eric A, Monack, Denise M, von Moltke, Jakob, Cado, Dragana, Dietrich, William F, Witte, Chelsea E, Henry, Thomas, Tsolis, Renée M, Sun, Yao-Hui

“…The molecular components of inflammasomes and what they sense are poorly defined. Vance and colleagues now show the carboxy-terminal 35 amino acids of…”
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PGD2 and CRTH2 counteract Type 2 cytokine-elicited intestinal epithelial responses during helminth infection by Oyesola, Oyebola O, Shanahan, Michael T, Kanke, Matt, Mooney, Bridget M, Webb, Lauren M, Smita, Shuchi, Matheson, Macy K, Campioli, Pamela, Pham, Duc, Früh, Simon P, McGinty, John W, Churchill, Madeline J, Cahoon, Jordan L, Sundaravaradan, Pavithra, Flitter, Becca A, Mouli, Karthik, Nadjsombati, Marija S, Kamynina, Elena, Peng, Seth A, Cubitt, Rebecca L, Gronert, Karsten, Lord, James D, Rauch, Isabella, von Moltke, Jakob, Sethupathy, Praveen, Tait Wojno, Elia D

“…Type 2 inflammation is associated with epithelial cell responses, including goblet cell hyperplasia, that promote worm expulsion during intestinal helminth…”
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