Search Results - "Von Maltitz, Pascal"

Utilization of Aminoguanidine Prevents Cytotoxic Effects of Semen by Harms, Mirja, von Maltitz, Pascal, Groß, Rüdiger, Mayer, Benjamin, Deniz, Miriam, Müller, Janis, Münch, Jan

“…Studies of human semen in cell or tissue culture are hampered by the high cytotoxic activity of this body fluid. The components responsible for the cell…”
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BNT162b2 booster after heterologous prime-boost vaccination induces potent neutralizing antibodies and T cell reactivity against SARS-CoV-2 Omicron BA.1 in young adults by Seidel, Alina, Zanoni, Michelle, Groß, Rüdiger, Krnavek, Daniela, Erdemci-Evin, Sümeyye, von Maltitz, Pascal, Albers, Dan P. J., Conzelmann, Carina, Liu, Sichen, Weil, Tatjana, Mayer, Benjamin, Hoffmann, Markus, Pöhlmann, Stefan, Beil, Alexandra, Kroschel, Joris, Kirchhoff, Frank, Münch, Jan, Müller, Janis A.

“…In light of the decreasing immune protection against symptomatic SARS-CoV-2 infection after initial vaccinations and the now dominant immune-evasive Omicron…”
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SARS-CoV-2 vaccination of convalescents boosts neutralization capacity against Omicron subvariants BA.1, BA.2 and BA.5 and can be predicted by anti-S antibody concentrations in serological assays by Seidel, Alina, Hoffmann, Simone, Jahrsdörfer, Bernd, Körper, Sixten, Ludwig, Carolin, Vieweg, Christiane, Albers, Dan, von Maltitz, Pascal, Müller, Rebecca, Lotfi, Ramin, Wuchter, Patrick, Klüter, Harald, Kirchhoff, Frank, Schmidt, Michael, Münch, Jan, Schrezenmeier, Hubert

“…Recent data on immune evasion of new SARS-CoV-2 variants raise concerns about the efficacy of antibody-based COVID-19 therapies. Therefore, in this study the…”
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Inhibitors of Activin Receptor-like Kinase 5 Interfere with SARS-CoV-2 S-Protein Processing and Spike-Mediated Cell Fusion via Attenuation of Furin Expression by Mezger, Maja C., Conzelmann, Carina, Weil, Tatjana, von Maltitz, Pascal, Albers, Dan P. J., Münch, Jan, Stamminger, Thomas, Schilling, Eva-Maria

“…Screening of a protein kinase inhibitor library identified SB431542, targeting activin receptor-like kinase 5 (ALK5), as a compound interfering with SARS-CoV-2…”
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Strong attenuation of SARS-CoV-2 Omicron BA.1 and increased replication of the BA.5 subvariant in human cardiomyocytes by Nchioua, Rayhane, Diofano, Federica, Noettger, Sabrina, von Maltitz, Pascal, Stenger, Steffen, Zech, Fabian, Münch, Jan, Sparrer, Konstantin M. J., Just, Steffen, Kirchhoff, Frank

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Semen enhances transmitted/founder HIV-1 infection and only marginally reduces antiviral activity of broadly neutralizing antibodies by von Maltitz, Pascal, Wettstein, Lukas, Weil, Tatjana, Schommers, Philipp, Klein, Florian, Münch, Jan

“…Topically applied microbicides may play a critical role in preventing sexual transmission of human immunodeficiency virus type 1 (HIV-1); however, their…”
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Peptide Bispecifics Inhibiting HIV‑1 Infection by an Orthogonal Chemical and Supramolecular Strategy by Schauenburg, Dominik, Zech, Fabian, Heck, Astrid Johanna, von Maltitz, Pascal, Harms, Mirja, Führer, Siska, Alleva, Nico, Münch, Jan, Kuan, Seah Ling, Kirchhoff, Frank, Weil, Tanja

“…Viral infections pose a significant threat to human health, and effective antiviral strategies are urgently needed. Antiviral peptides have emerged as a…”
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ACE2-EGFR-MAPK signaling contributes to SARS-CoV-2 infection by Engler, Melanie, Albers, Dan, Von Maltitz, Pascal, Groß, Rüdiger, Münch, Jan, Cirstea, Ion Cristian

“…SARS-CoV-2 triggered the most severe pandemic of recent times. To enter into a host cell, SARS-CoV-2 binds to the angiotensin-converting enzyme 2 (ACE2)…”
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Spermine and spermidine bind CXCR4 and inhibit CXCR4-but not CCR5-tropic HIV-1 infection by Harms, Mirja, Smith, Nikaïa, Han, Mingyu, Groß, Rüdiger, von Maltitz, Pascal, Stürzel, Christina, Ruiz-Blanco, Yasser B, Almeida-Hernández, Yasser, Rodriguez-Alfonso, Armando, Cathelin, Dominique, Caspar, Birgit, Tahar, Bouceba, Sayettat, Sophie, Bekaddour, Nassima, Vanshylla, Kanika, Kleipass, Franziska, Wiese, Sebastian, Ständker, Ludger, Klein, Florian, Lagane, Bernard, Boonen, Arnaud, Schols, Dominique, Benichou, Serge, Sanchez-Garcia, Elsa, Herbeuval, Jean-Philippe, Münch, Jan

“…Semen is an important vector for sexual HIV-1 transmission. Although CXCR4-tropic (X4) HIV-1 may be present in semen, almost exclusively CCR5-tropic (R5) HIV-1…”
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Spermine and spermidine bind CXCR4 and inhibit CXCR4- but not CCR5-tropic HIV-1 infection by Harms, Mirja, Smith, Nikaïa, Han, Mingyu, Groß, Rüdiger, von Maltitz, Pascal, Stürzel, Christina, Ruiz-Blanco, Yasser B, Almeida-Hernández, Yasser, Rodriguez-Alfonso, Armando, Cathelin, Dominique, Caspar, Birgit, Tahar, Bouceba, Sayettat, Sophie, Bekaddour, Nassima, Vanshylla, Kanika, Kleipass, Franziska, Wiese, Sebastian, Ständker, Ludger, Klein, Florian, Lagane, Bernard, Boonen, Arnaud, Schols, Dominique, Benichou, Serge, Sanchez-Garcia, Elsa, Herbeuval, Jean-Philippe, Münch, Jan

“…Semen is an important vector for sexual HIV-1 transmission. Although CXCR4-tropic (X4) HIV-1 may be present in semen, almost exclusively CCR5-tropic (R5) HIV-1…”
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Phosphatidylserine-exposing extracellular vesicles in body fluids are an innate defence against apoptotic mimicry viral pathogens by Groß, Rüdiger, Reßin, Hanna, von Maltitz, Pascal, Albers, Dan, Schneider, Laura, Bley, Hanna, Hoffmann, Markus, Cortese, Mirko, Gupta, Dhanu, Deniz, Miriam, Choi, Jae-Yeon, Jansen, Jenny, Preußer, Christian, Seehafer, Kai, Pöhlmann, Stefan, Voelker, Dennis R., Goffinet, Christine, Pogge-von Strandmann, Elke, Bunz, Uwe, Bartenschlager, Ralf, El Andaloussi, Samir, Sparrer, Konstantin M. J., Herker, Eva, Becker, Stephan, Kirchhoff, Frank, Münch, Jan, Müller, Janis A.

“…Some viruses are rarely transmitted orally or sexually despite their presence in saliva, breast milk, or semen. We previously identified that extracellular…”
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