HPV-Positive Oropharyngeal Cancer Via p16 Immunohistochemistry in Japan

Objectives: Human papillomavirus (HPV) has emerged as a driving cause of head and neck cancer, but investigations outside the West are limited. A p16 immunohistochemistry is a commonly used biomarker for HPV cancers. We sought to investigate the pathology and rates of HPV head and neck oropharyngeal...

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Bibliographic Details
Published in:	Annals of otology, rhinology & laryngology Vol. 126; no. 2; pp. 152 - 158
Main Authors:	Toman, Julia, Von Larson, Scott, Umeno, Hirohito, Kurita, Takashi, Furusaka, Tohru, Hasegawa, Hisashi, Prasad, Manju L., Sasaki, Clarence T.
Format:	Journal Article
Language:	English
Published:	Los Angeles, CA SAGE Publications 01-02-2017
Subjects:	Aged Carcinoma, Squamous Cell - epidemiology Carcinoma, Squamous Cell - metabolism Carcinoma, Squamous Cell - mortality Carcinoma, Squamous Cell - virology Cyclin-Dependent Kinase Inhibitor p16 - metabolism Female Head and Neck Neoplasms - epidemiology Head and Neck Neoplasms - metabolism Head and Neck Neoplasms - mortality Head and Neck Neoplasms - virology Humans Immunohistochemistry Japan - epidemiology Male Middle Aged Oropharyngeal Neoplasms - epidemiology Oropharyngeal Neoplasms - metabolism Oropharyngeal Neoplasms - mortality Oropharyngeal Neoplasms - virology Papillomavirus Infections - epidemiology Papillomavirus Infections - metabolism Sex Distribution Smoking - epidemiology Squamous Cell Carcinoma of Head and Neck Japan p16 immunohistochemistry oropharyngeal cancer Japan HPV
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Summary:	Objectives: Human papillomavirus (HPV) has emerged as a driving cause of head and neck cancer, but investigations outside the West are limited. A p16 immunohistochemistry is a commonly used biomarker for HPV cancers. We sought to investigate the pathology and rates of HPV head and neck oropharyngeal cancer in Japan via p16 immunohistochemistry at 2 institutions in Japan. Methods: Fifty-nine oropharyngeal specimens from 2 university hospitals in Japan were examined for morphology and p16 immunohistochemistry. The rate of p16 positivity was then determined, and the 2 groups were compared for differences in age, smoking history, gender, and stage of presentation and mortality. Results: The rate of p16 positivity among the oropharyngeal specimens was 29.5%. There were important differences in the pathology compared to morphology usually seen in the US. The patients with p16+ cancer tended to be younger. There was no significant difference in smoking status. Patients with p16+ cancers trended toward better survival. Conclusion: There appears to be a geographical difference in HPV rates of oropharyngeal cancers with persistently lower rates in Asian countries when compared to Western Europe and the US. Conclusions about HPV head and neck squamous cell carcinoma (HNSCC) in Western countries may not be generalizable across the globe at this time.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0003-4894 1943-572X
DOI:	10.1177/0003489416681582