Behavioral effects of estradiol therapy in ovariectomized rats depend on the age when the treatment is initiated

Clinical studies suggest that aging may affect the neural outcome of estrogen therapy in postmenopausal women. In this study we have assessed whether age influences the behavioral outcome of estradiol therapy in rats. Animals were ovariectomized at 2 or 20 months of age. Immediately after ovariectom...

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Bibliographic Details
Published in:	Experimental gerontology Vol. 47; no. 1; pp. 93 - 99
Main Authors:	Diz-Chaves, Yolanda, Kwiatkowska-Naqvi, Anita, Von Hülst, Hendrik, Pernía, Olga, Carrero, Paloma, Garcia-Segura, Luis M.
Format:	Journal Article
Language:	English
Published:	England Elsevier Inc 2012
Subjects:	Age Factors Animals Anxiety - prevention & control Anxiety-like behavior Behavior, Animal - drug effects Brain - drug effects Circular open field Depression - prevention & control Depressive-like behavior Estradiol - pharmacology Exercise Test Female Forced swim test Memory - drug effects Object recognition memory Ovariectomy Rats Rats, Wistar Recognition (Psychology) Swimming Depressive-like behavior Anxiety-like behavior Object recognition memory Forced swim test Circular open field
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Summary:	Clinical studies suggest that aging may affect the neural outcome of estrogen therapy in postmenopausal women. In this study we have assessed whether age influences the behavioral outcome of estradiol therapy in rats. Animals were ovariectomized at 2 or 20 months of age. Immediately after ovariectomy animals were treated for 10 weeks with estradiol valerate or vehicle. Estradiol therapy decreased body weight in both young and older rats compared to animals injected with vehicle. In contrast, estradiol treatment improved object recognition memory and decreased anxiety-like behavior in the circular open field of older but not young rats and decreased depressive-like behavior of young but not older animals. Thus, our findings indicate that age affects the outcome of estradiol therapy in the brain. ► Estradiol reduced anxiety-like behavior in aged rats. ► Estradiol increased object recognition in aged rats. ► Estradiol decreased depressive-like behavior in young but not in aged rats. ► The age of the animals affects the outcome of estradiol therapy in brain.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0531-5565 1873-6815
DOI:	10.1016/j.exger.2011.10.008