Hibiscus sabdariffa ethanolic extract modulates adipokine levels, decreases visceral fat and improves glycemic profile in high-fat/sugar diet-induced obese rats

Hibiscus sabdariffa ethanolic extract modulates adipokine levels, decreases visceral fat and improves glycemic profile in high-fat/sugar diet-induced obese rats

Purpose The purpose of this study is to evaluate the effect of Hibiscus sabdariffa ethanolic extract (HsE) on protein levels of tumor necrosis factor (TNF)-α, interleukin (IL)-6, adiponectin and leptin in adipose tissue, as well as on the lipid and glycemic profiles of high-fat/sugar diet-induced ob...

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Bibliographic Details
Published in:Nutrition and food science Vol. 51; no. 2; pp. 222 - 233
Main Authors: Von Dentz, Karla E, Silva, Bianca S, Queiroz, Eveline A.I.F, Bomfim, Gisele F, Nascimento, André F, Sugizaki, Mário M, Luvizotto, Renata A.M
Format: Journal Article
Language:English
Published: Bradford Emerald Publishing Limited 19-02-2021
Emerald Group Publishing Limited
Subjects:
Adipocytes
Adiponectin
Adipose tissue
Animals
Biochemical analysis
Body weight gain
Cholesterol
Diet
Experiments
Fatty acids
Glucose
Glucose tolerance
Health services
Hibiscus sabdariffa
High fat diet
Interleukin 6
Laboratories
Leptin
Lipids
Lipoproteins
Metabolism
Obesity
Proteins
Rodents
Roselle
Sugar
Tumor necrosis factor-TNF
Tumor necrosis factor-α
Variance analysis
Brazil
United States > US
California
Obesity
Adipose tissue
Adipokines
Glycemia
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Summary:Purpose The purpose of this study is to evaluate the effect of Hibiscus sabdariffa ethanolic extract (HsE) on protein levels of tumor necrosis factor (TNF)-α, interleukin (IL)-6, adiponectin and leptin in adipose tissue, as well as on the lipid and glycemic profiles of high-fat/sugar diet-induced obese (DIO) rats. Design/methodology/approach Obesity was induced in male Wistar rats through a high-fat/sugar diet provided for eight weeks. Control rats received a standard diet. The high-fat/sugar DIO animals were subsequently randomized into DIO (n = 8) and DIO treated with HsE (DIO + HsE, n = 8, 150 mg/kg/day) by gavage, for additional eight weeks. Oral glucose tolerance test was performed, and blood samples and epididymal adipose tissue were collected for biochemical analysis and adipokine protein level evaluation, respectively. Findings Compared to the DIO rats, HsE treatment decreased weight gain (50.6%) and mesenteric fat (42%), indicated as diminished visceral fat (22.5%). HsE did not affect the lipid profile and TNF-α levels in adipose tissue; however, it effectively prevented a 13% increase in fasting glucose levels and improved glucose tolerance. Compared with the C group, HsE normalized the adiponectin levels and leptin/adiponectin ratio and decreased the IL-6 (55%) and leptin (18.6%) levels in adipose tissue of obese rats. Originality/value HsE improves adipokine protein levels in high-fat/sugar DIO rats, demonstrating the clinical efficacy of HsE in the treatment of obesity and obesity-related diseases.
ISSN:0034-6659
1758-6917
DOI:10.1108/NFS-03-2020-0092