Search Results - "Von Delft, F"
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A Crystallographic Snapshot of SARS-CoV-2 Main Protease Maturation Process
Published in Journal of molecular biology (03-09-2021)“…[Display omitted] •Crystal structure of the immature form of Mpro (1.6A).•Immature form of Mpro in complex with 5 fragments.•Crystal structure of Mpro C145S…”
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The crystal structure of human GLRX5: iron-sulfur cluster co-ordination, tetrameric assembly and monomer activity
Published in Biochemical journal (15-01-2011)“…Human GLRX5 (glutaredoxin 5) is an evolutionarily conserved thiol-disulfide oxidoreductase that has a direct role in the maintenance of normal cytosolic and…”
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WONKA: objective novel complex analysis for ensembles of protein–ligand structures
Published in Journal of computer-aided molecular design (01-10-2015)“…WONKA is a tool for the systematic analysis of an ensemble of protein–ligand structures. It makes the identification of conserved and unusual features within…”
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Status of the crystallography beamlines at Diamond Light Source
Published in European physical journal plus (01-03-2015)“…X-ray crystallography is one of the most widely supported areas of science at Diamond Light Source and is the core technique on a third of the beamlines,…”
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Crystal Structure of Escherichia coli Ketopantoate Reductase at 1.7 Å Resolution and Insight into the Enzyme Mechanism
Published in Biochemistry (Easton) (04-12-2001)“…Ketopantoate reductase (KPR, EC 1.1.1.169) catalyzes the NADPH-dependent reduction of ketopantoate to pantoate on the pantothenate (vitamin B5) biosynthetic…”
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A Crystallographic Snapshot of SARS-CoV-2 Main Protease Maturation Process : SARS-CoV-2 Mpro maturation
Published in Journal of molecular biology (03-09-2021)“…SARS-CoV-2 is the causative agent of COVID-19. The dimeric form of the viral Mpro is responsible for the cleavage of the viral polyprotein in 11 sites,…”
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Target 2035 - update on the quest for a probe for every protein
Published in RSC medicinal chemistry (27-01-2022)“…Twenty years after the publication of the first draft of the human genome, our knowledge of the human proteome is still fragmented. The challenge of…”
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Fragment binding to the Nsp3 macrodomain of SARS-CoV-2 identified through crystallographic screening and computational docking
Published in Science advances (01-04-2021)“…The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) macrodomain within the nonstructural protein 3 counteracts host-mediated antiviral adenosine…”
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Crystal structure of fibroblast growth factor receptor ectodomain bound to ligand and heparin
Published in Nature (London) (26-10-2000)“…Fibroblast growth factors (FGFs) are a large family of structurally related proteins with a wide range of physiological and pathological activities. Signal…”
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Setting high-resolution limits for anisotropic data
Published in Acta crystallographica. Section A, Foundations of crystallography (07-08-2012)“…Abstract only…”
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The Crystal Structure of E. coli Pantothenate Synthetase Confirms It as a Member of the Cytidylyltransferase Superfamily
Published in Structure (London) (09-05-2001)“…Background: Pantothenate synthetase (EC 6.3.2.1) is the last enzyme of the pathway of pantothenate (vitamin B 5) synthesis. It catalyzes the condensation of…”
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The Crystal Structure of Shikimate Dehydrogenase (AroE) Reveals a Unique NADPH Binding Mode
Published in Journal of Bacteriology (01-07-2003)“…Article Usage Stats Services JB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Structure of E. coli ketopantoate hydroxymethyl transferase complexed with ketopantoate and Mg2+, solved by locating 160 selenomethionine sites
Published in Structure (London) (01-08-2003)“…We report the crystal structure of E. coli ketopantoate hydroxymethyltransferase (KPHMT) at 1.9 A resolution, in complex with its product, ketopantoate. KPHMT…”
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XDX – an initial solution to crystallization
Published in Acta crystallographica. Section A, Foundations of crystallography (22-08-2011)“…Abstract only…”
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Two-wavelength MAD phasing and radiation damage: a case study
Published in Journal of synchrotron radiation (01-05-2005)“…Radiation damage affects MAD experiments in two ways: (i) increased absorption by the crystal at the wavelengths of interest for the experiment results in…”
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Crystal structure of a PIN (PilT N-terminus) domain (AF0591) from Archaeoglobus fulgidus at 1.90 Å resolution
Published in Proteins, structure, function, and bioinformatics (01-08-2004)Get full text
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Optimizing signal-to-noise on a home X-ray source for the analysis of microcrystals
Published in Acta crystallographica. Section A, Foundations of crystallography (23-08-2008)“…Abstract only…”
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A family-wide approach to structure-based inhibitor design for protein tyrosine phosphatases
Published in Acta crystallographica. Section A, Foundations of crystallography (23-08-2008)“…Abstract only…”
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Structural genomics on human kinases at SGC Oxford
Published in Acta crystallographica. Section A, Foundations of crystallography (06-08-2006)“…Abstract only…”
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Crystal structure of O-acetylserine sulfhydrylase (TM0665) from Thermotoga maritima at 1.8 Å resolution
Published in Proteins, structure, function, and bioinformatics (01-08-2004)Get full text
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