Search Results - "Volpicelli, Laura A"

Neuronal vulnerability in Parkinson disease: Should the focus be on axons and synaptic terminals? by Wong, Yvette C., Luk, Kelvin, Purtell, Kerry, Burke Nanni, Samuel, Stoessl, A. Jon, Trudeau, Louis‐Eric, Yue, Zhenyu, Krainc, Dimitri, Oertel, Wolfgang, Obeso, Jose A., Volpicelli‐Daley, Laura A.

“…ABSTRACT While current effective therapies are available for the symptomatic control of PD, treatments to halt the progressive neurodegeneration still do not…”
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Sensitivity and specificity of phospho‐Ser129 α‐synuclein monoclonal antibodies by Delic, Vedad, Chandra, Sidhanth, Abdelmotilib, Hisham, Maltbie, Tyler, Wang, Shijie, Kem, Danielle, Scott, Hunter J., Underwood, Rachel N., Liu, Zhiyong, Volpicelli‐Daley, Laura A., West, Andrew B.

“…α‐Synuclein (α‐syn) is an abundant presynaptic protein that is the primary constituent of inclusions that define Lewy body diseases (LBDs). In these…”
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Initiation and propagation of α-synuclein aggregation in the nervous system by Hijaz, Baraa A, Volpicelli-Daley, Laura A

“…The two main pathological hallmarks of Parkinson's disease are loss of dopamine neurons in the substantia nigra pars compacta and proteinaceous amyloid fibrils…”
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Differential LRRK2 expression in the cortex, striatum, and substantia nigra in transgenic and nontransgenic rodents by West, Andrew B., Cowell, Rita M., Daher, João P.L., Moehle, Mark S., Hinkle, Kelly M., Melrose, Heather L., Standaert, David G., Volpicelli-Daley, Laura A.

“…ABSTRACT Mutations in leucine‐rich repeat kinase 2 (LRRK2) are found in a significant proportion of late‐onset Parkinson's disease (PD) patients. Elucidating…”
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microRNA-155 Regulates Alpha-Synuclein-Induced Inflammatory Responses in Models of Parkinson Disease by Thome, Aaron D, Harms, Ashley S, Volpicelli-Daley, Laura A, Standaert, David G

“…Increasing evidence points to inflammation as a chief mediator of Parkinson's disease (PD), a progressive neurodegenerative disorder characterized by loss of…”
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Effects of α-synuclein on axonal transport by Volpicelli-Daley, Laura A

“…Abstract Lewy bodies and Lewy neurites composed primarily of α-synuclein characterize synucleinopathies including Parkinson ' s disease (PD) and Dementia with…”
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α-Synuclein fibril-induced inclusion spread in rats and mice correlates with dopaminergic Neurodegeneration by Abdelmotilib, Hisham, Maltbie, Tyler, Delic, Vedad, Liu, Zhiyong, Hu, Xianzhen, Fraser, Kyle B, Moehle, Mark S, Stoyka, Lindsay, Anabtawi, Nadia, Krendelchtchikova, Valentina, Volpicelli-Daley, Laura A, West, Andrew

“…Abstract Proteinaceous inclusions in neurons, composed primarily of α-synuclein, define the pathology in several neurodegenerative disorders. Neurons can…”
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Abrogation of α-synuclein–mediated dopaminergic neurodegeneration in LRRK2-deficient rats by Daher, João P. L., Volpicelli-Daley, Laura A., Blackburn, Jonathan P., Moehle, Mark S., West, Andrew B.

“…Missense mutations in the leucine-rich repeat kinase 2 (LRRK2) gene can cause late-onset Parkinson disease. Past studies have provided conflicting evidence for…”
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LRRK2 Antisense Oligonucleotides Ameliorate α-Synuclein Inclusion Formation in a Parkinson’s Disease Mouse Model by Zhao, Hien Tran, John, Neena, Delic, Vedad, Ikeda-Lee, Karli, Kim, Aneeza, Weihofen, Andreas, Swayze, Eric E., Kordasiewicz, Holly B., West, Andrew B., Volpicelli-Daley, Laura A.

“…No treatments exist to slow or halt Parkinson’s disease (PD) progression; however, inhibition of leucine-rich repeat kinase 2 (LRRK2) activity represents one…”
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Behavioral defects associated with amygdala and cortical dysfunction in mice with seeded α-synuclein inclusions by Stoyka, Lindsay E., Arrant, Andrew E., Thrasher, Drake R., Russell, Dreson L., Freire, Jennifer, Mahoney, Casey L., Narayanan, Ashwin, Dib, Aseel G., Standaert, David G., Volpicelli-Daley, Laura A.

“…Parkinson's disease (PD) is defined by motor symptoms such as tremor at rest, bradykinesia, postural instability, and stiffness. In addition to the classical…”
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Pα-syn mitotoxicity is linked to MAPK activation and involves tau phosphorylation and aggregation at the mitochondria by Grassi, Diego, Diaz-Perez, Natalia, Volpicelli-Daley, Laura A., Lasmézas, Corinne Ida

“…We recently identified a truncated and phosphorylated form of α-synuclein, pα-syn*, as a key neurotoxic α-synuclein species found in cultured neurons, as well…”
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Molecular Mechanisms Underlying Synaptic and Axon Degeneration in Parkinson's Disease by Gcwensa, Nolwazi Z, Russell, Drèson L, Cowell, Rita M, Volpicelli-Daley, Laura A

“…Parkinson's disease (PD) is a progressive neurodegenerative disease that impairs movement as well as causing multiple other symptoms such as autonomic…”
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Characterization of Central Inhibitory Muscarinic Autoreceptors by the Use of Muscarinic Acetylcholine Receptor Knock-Out Mice by Zhang, Weilie, Basile, Anthony S, Gomeza, Jesus, Volpicelli, Laura A, Levey, Allan I, Wess, Jurgen

“…Forebrain muscarinic acetylcholine (ACh) receptors (mAChRs; M1-M5) are predicted to play important roles in many fundamental central functions, including…”
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Excitatory synaptic structural abnormalities produced by templated aggregation of α-syn in the basolateral amygdala by Gcwensa, Nolwazi Z., Russell, Dreson L., Long, Khaliah Y., Brzozowski, Charlotte F., Liu, Xinran, Gamble, Karen L., Cowell, Rita M., Volpicelli-Daley, Laura A.

“…Parkinson's disease (PD) and Dementia with Lewy bodies (DLB) are characterized by neuronal α-synuclein (α-syn) inclusions termed Lewy Pathology, which are…”
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Pathological α-synuclein recruits LRRK2 expressing pro-inflammatory monocytes to the brain by Xu, Enquan, Boddu, Ravindra, Abdelmotilib, Hisham A, Sokratian, Arpine, Kelly, Kaela, Liu, Zhiyong, Bryant, Nicole, Chandra, Sidhanth, Carlisle, Samantha M, Lefkowitz, Elliot J, Harms, Ashley S, Benveniste, Etty N, Yacoubian, Talene A, Volpicelli-Daley, Laura A, Standaert, David G, West, Andrew B

“…Leucine rich repeat kinase 2 (LRRK2) and SNCA are genetically linked to late-onset Parkinson's disease (PD). Aggregated α-synuclein pathologically defines PD…”
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Exogenous α-Synuclein Fibrils Induce Lewy Body Pathology Leading to Synaptic Dysfunction and Neuron Death by Volpicelli-Daley, Laura A., Luk, Kelvin C., Patel, Tapan P., Tanik, Selcuk A., Riddle, Dawn M., Stieber, Anna, Meaney, David F., Trojanowski, John Q., Lee, Virginia M.-Y.

“…Inclusions composed of α-synuclein (α-syn), i.e., Lewy bodies (LBs) and Lewy neurites (LNs), define synucleinopathies including Parkinson's disease (PD) and…”
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How can rAAV‐α‐synuclein and the fibril α‐synuclein models advance our understanding of Parkinson's disease? by Volpicelli‐Daley, Laura A., Kirik, Deniz, Stoyka, Lindsay E., Standaert, David G., Harms, Ashley S.

“…Animal models of Parkinson's disease (PD) are important for understanding the mechanisms of the disease and can contribute to developing and validating novel…”
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Parkinson's disease pathology is directly correlated to SIRT3 in human subjects and animal models: Implications for AAV.SIRT3-myc as a disease-modifying therapy by Trinh, Dennison, Israwi, Ahmad R., Brar, Harsimar, Villafuerte, Jose E.A., Laylo, Ruella, Patel, Humaiyra, Jafri, Sabika, Al Halabi, Lina, Sinnathurai, Shaumia, Reehal, Kiran, Shi, Alyssa, Gnanamanogaran, Vayisnavei, Garabedian, Natalie, Pham, Ivy, Thrasher, Drake, Monnier, Philippe P., Volpicelli-Daley, Laura A., Nash, Joanne E.

“…In Parkinson's disease (PD), post-mortem studies in affected brain regions have demonstrated a decline in mitochondrial number and function. This combined with…”
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Corrigendum to “α-Synuclein fibril-induced inclusion spread in rats and mice correlates with dopaminergic Neurodegeneration” [Neurobiol. Dis., Volume 105 (2017) Article 84, 98] by Abdelmotilib, Hisham, Maltbie, Tyler, Delic, Vedad, Liu, Zhiyong, Hu, Xianzhen, Fraser, Kyle B., Moehle, Mark S., Stoyka, Lindsay, Anabtawi, Nadia, Krendelchtchikova, Valentina, Volpicelli-Daley, Laura A., West, Andrew

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α-Synuclein fibril-induced paradoxical structural and functional defects in hippocampal neurons by Froula, Jessica M, Henderson, Benjamin W, Gonzalez, Jose Carlos, Vaden, Jada H, Mclean, John W, Wu, Yumei, Banumurthy, Gokulakrishna, Overstreet-Wadiche, Linda, Herskowitz, Jeremy H, Volpicelli-Daley, Laura A

“…Neuronal inclusions composed of α-synuclein (α-syn) characterize Parkinson's Disease (PD) and Dementia with Lewy bodies (DLB). Cognitive dysfunction defines…”
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