Search Results - "Volpi, Daniele"

A Cdc7 kinase inhibitor restricts initiation of DNA replication and has antitumor activity by Ciavolella, Antonella, Rainoldi, Sonia, Isacchi, Antonella, Santocanale, Corrado, Tenca, Pierluigi, Montagnoli, Alessia, Valsasina, Barbara, Brotherton, Deborah, Croci, Valter, Cattoni, Marina, Patton, Veronica, Avanzi, Nilla, Alzani, Rachele, Tibolla, Marcello, Volpi, Daniele, Bensimon, Aaron, Albanese, Clara, Molinari, Antonio, Pesenti, Enrico, Healy, Sandra, Sola, Francesco, Moll, Jurgen, Vanotti, Ermes, Menichincheri, Maria, Marchesi, Vanessa, Fiorentini, Francesco, Ballinari, Dario

“…Cdc7 is an essential kinase that promotes DNA replication by activating origins of replication. Here, we characterized the potent Cdc7 inhibitor PHA-767491 ( 1…”
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Identification of 4,5-Dihydro-1H-pyrazolo[4,3-h]quinazoline Derivatives as a New Class of Orally and Selective Polo-Like Kinase 1 Inhibitors by Beria, Italo, Ballinari, Dario, Bertrand, Jay Aaron, Borghi, Daniela, Bossi, Roberto Tiberio, Brasca, Maria Gabriella, Cappella, Paolo, Caruso, Michele, Ceccarelli, Walter, Ciavolella, Antonella, Cristiani, Cinzia, Croci, Valter, De Ponti, Anna, Fachin, Gabriele, Ferguson, Ronald Dale, Lansen, Jacqueline, Moll, Jurgen Karl, Pesenti, Enrico, Posteri, Helena, Perego, Rita, Rocchetti, Maurizio, Storici, Paola, Volpi, Daniele, Valsasina, Barbara

“…Polo-like kinase 1 (Plk1) is a fundamental regulator of mitotic progression whose overexpression is often associated with oncogenesis and therefore is…”
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Cdc7 Kinase Inhibitors: 5-Heteroaryl-3-Carboxamido-2-Aryl Pyrroles as Potential Antitumor Agents. 1. Lead Finding by Menichincheri, Maria, Albanese, Clara, Alli, Cristina, Ballinari, Dario, Bargiotti, Alberto, Caldarelli, Marina, Ciavolella, Antonella, Cirla, Alessandra, Colombo, Maristella, Colotta, Francesco, Croci, Valter, D’Alessio, Roberto, D’Anello, Matteo, Ermoli, Antonella, Fiorentini, Francesco, Forte, Barbara, Galvani, Arturo, Giordano, Patrizia, Isacchi, Antonella, Martina, Katia, Molinari, Antonio, Moll, Jürgen K, Montagnoli, Alessia, Orsini, Paolo, Orzi, Fabrizio, Pesenti, Enrico, Pillan, Antonio, Roletto, Fulvia, Scolaro, Alessandra, Tatò, Marco, Tibolla, Marcellino, Valsasina, Barbara, Varasi, Mario, Vianello, Paola, Volpi, Daniele, Santocanale, Corrado, Vanotti, Ermes

“…Cdc7 serine/threonine kinase is a key regulator of DNA synthesis in eukaryotic organisms. Cdc7 inhibition through siRNA or prototype small molecules causes p53…”
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Cdc7 Kinase Inhibitors: Pyrrolopyridinones as Potential Antitumor Agents. 1. Synthesis and Structure–Activity Relationships by Vanotti, Ermes, Amici, Raffaella, Bargiotti, Alberto, Berthelsen, Jens, Bosotti, Roberta, Ciavolella, Antonella, Cirla, Alessandra, Cristiani, Cinzia, D’Alessio, Roberto, Forte, Barbara, Isacchi, Antonella, Martina, Katia, Menichincheri, Maria, Molinari, Antonio, Montagnoli, Alessia, Orsini, Paolo, Pillan, Antonio, Roletto, Fulvia, Scolaro, Alessandra, Tibolla, Marcellino, Valsasina, Barbara, Varasi, Mario, Volpi, Daniele, Santocanale, Corrado

“…Cdc7 kinase is an essential protein that promotes DNA replication in eukaryotic organisms. Genetic evidence indicates that Cdc7 inhibition can cause selective…”
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Optimization of 6,6-dimethyl pyrrolo[3,4- c]pyrazoles: Identification of PHA-793887, a potent CDK inhibitor suitable for intravenous dosing by Brasca, Maria Gabriella, Albanese, Clara, Alzani, Rachele, Amici, Raffaella, Avanzi, Nilla, Ballinari, Dario, Bischoff, James, Borghi, Daniela, Casale, Elena, Croci, Valter, Fiorentini, Francesco, Isacchi, Antonella, Mercurio, Ciro, Nesi, Marcella, Orsini, Paolo, Pastori, Wilma, Pesenti, Enrico, Pevarello, Paolo, Roussel, Patrick, Varasi, Mario, Volpi, Daniele, Vulpetti, Anna, Ciomei, Marina

“…We describe the synthesis of compounds with interesting biochemical and cellular characteristics. Optimization of the physico-chemical properties led to the…”
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Cell Division Cycle 7 Kinase Inhibitors: 1H-Pyrrolo[2,3-b]pyridines, Synthesis and Structure−Activity Relationships by Ermoli, Antonella, Bargiotti, Alberto, Brasca, Maria Gabriella, Ciavolella, Antonella, Colombo, Nicoletta, Fachin, Gabriele, Isacchi, Antonella, Menichincheri, Maria, Molinari, Antonio, Montagnoli, Alessia, Pillan, Antonio, Rainoldi, Sonia, Sirtori, Federico Riccardi, Sola, Francesco, Thieffine, Sandrine, Tibolla, Marcellino, Valsasina, Barbara, Volpi, Daniele, Santocanale, Corrado, Vanotti, Ermes

“…Cdc7 kinase has recently emerged as an attractive target for cancer therapy and low-molecular-weight inhibitors of Cdc7 kinase have been found to be effective…”
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First Cdc7 Kinase Inhibitors: Pyrrolopyridinones as Potent and Orally Active Antitumor Agents. 2. Lead Discovery by Menichincheri, Maria, Bargiotti, Alberto, Berthelsen, Jens, Bertrand, Jay A, Bossi, Roberto, Ciavolella, Antonella, Cirla, Alessandra, Cristiani, Cinzia, Croci, Valter, D’Alessio, Roberto, Fasolini, Marina, Fiorentini, Francesco, Forte, Barbara, Isacchi, Antonella, Martina, Katia, Molinari, Antonio, Montagnoli, Alessia, Orsini, Paolo, Orzi, Fabrizio, Pesenti, Enrico, Pezzetta, Daniele, Pillan, Antonio, Poggesi, Italo, Roletto, Fulvia, Scolaro, Alessandra, Tatò, Marco, Tibolla, Marcellino, Valsasina, Barbara, Varasi, Mario, Volpi, Daniele, Santocanale, Corrado, Vanotti, Ermes

“…Cdc7 kinase is a key regulator of the S-phase of the cell cycle, known to promote the activation of DNA replication origins in eukaryotic organisms. Cdc7…”
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Identification of 4,5-Dihydro-1 H -pyrazolo[4,3- h ]quinazoline Derivatives as a New Class of Orally and Selective Polo-Like Kinase 1 Inhibitors by Beria, Italo, Ballinari, Dario, Bertrand, Jay Aaron, Borghi, Daniela, Bossi, Roberto Tiberio, Brasca, Maria Gabriella, Cappella, Paolo, Caruso, Michele, Ceccarelli, Walter, Ciavolella, Antonella, Cristiani, Cinzia, Croci, Valter, De Ponti, Anna, Fachin, Gabriele, Ferguson, Ronald Dale, Lansen, Jacqueline, Moll, Jurgen Karl, Pesenti, Enrico, Posteri, Helena, Perego, Rita, Rocchetti, Maurizio, Storici, Paola, Volpi, Daniele, Valsasina, Barbara

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Online tracking of interventional devices for endovascular aortic repair by Volpi, Daniele, Sarhan, Mhd H., Ghotbi, Reza, Navab, Nassir, Mateus, Diana, Demirci, Stefanie

“…Purpose The continuous integration of innovative imaging modalities into conventional vascular surgery rooms has led to an urgent need for computer assistance…”
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Identification of Potent Pyrazolo[4,3-h]quinazoline-3-carboxamides as Multi-Cyclin-Dependent Kinase Inhibitors by Traquandi, Gabriella, Ciomei, Marina, Ballinari, Dario, Casale, Elena, Colombo, Nicoletta, Croci, Valter, Fiorentini, Francesco, Isacchi, Antonella, Longo, Antonio, Mercurio, Ciro, Panzeri, Achille, Pastori, Wilma, Pevarello, Paolo, Volpi, Daniele, Roussel, Patrick, Vulpetti, Anna, Brasca, Maria Gabriella

“…Abnormal proliferation mediated by disruption of the mechanisms that keep the cell cycle under control is a hallmark of virtually all cancer cells. Compounds…”
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Thieno[3,2- c]pyrazoles: A novel class of Aurora inhibitors with favorable antitumor activity by Bindi, Simona, Fancelli, Daniele, Alli, Cristina, Berta, Daniela, Bertrand, Jay A., Cameron, Alexander D., Cappella, Paolo, Carpinelli, Patrizia, Cervi, Giovanni, Croci, Valter, D’Anello, Matteo, Forte, Barbara, Laura Giorgini, M., Marsiglio, Aurelio, Moll, Juergen, Pesenti, Enrico, Pittalà, Valeria, Pulici, Maurizio, Riccardi-Sirtori, Federico, Roletto, Fulvia, Soncini, Chiara, Storici, Paola, Varasi, Mario, Volpi, Daniele, Zugnoni, Paola, Vianello, Paola

“…In this paper we report on the optimization of the thieno[3,2- c]pyrazole series as inhibitors of the Aurora kinases to give a promising lead compound endowed…”
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Abstract DD01-01: NMS-1116354: More than an inhibitor of Cdc 7 kinase in S-phase by Colotta, Francesco, Moll, Jurgen, Valsasina, Barbara, Vanotti, Ermes, Rainoldi, Sonia, Sola, Francesco, Marchesi, Vanessa, Menichincheri, Maria, Ciavolella, Antonella, Patton, Veronica, Albanese, Clara, Volpi, Daniele, Avanzi, Nilla, Ballinari, Dario, Fiorentini, Francesco, Isacchi, Antonella, Pesenti, Enrico, Galvani, Arturo, Santocanale, Corrado, Montagnoli, Alessia

“…Abstract Most of the widely used anticancer drugs target the elongation step of DNA synthesis, either directly, for example by restricting the pool of dNTPs or…”
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Abstract C202: Targeting the mitotic checkpoint for cancer therapy with NMS-P715, a novel MPS1 kinase inhibitor by Colombo, Riccardo, Caldarelli, Marina, Mennecozzi, Milena, Giorgini, Maria L., Sola, Francesco, Cappella, Paolo, Ballinari, Dario, Perrera, Claudia, Re Depaolini, Stefania, Rusconi, Luisa, Avanzi, Nilla, Volpi, Daniele, Bossi, Roberto, Bertrand, Jay A., Pesenti, Enrico, Isacchi, Antonella, Donati, Daniele, Moll, Jurgen

“…Abstract The Spindle Assembly Checkpoint (SAC) is a mitotic mechanism specifically required for proper chromosomal segregation ensuring that cells do not…”
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Cell Division Cycle 7 Kinase Inhibitors: 1 H -Pyrrolo[2,3- b ]pyridines, Synthesis and Structure−Activity Relationships by Ermoli, Antonella, Bargiotti, Alberto, Brasca, Maria Gabriella, Ciavolella, Antonella, Colombo, Nicoletta, Fachin, Gabriele, Isacchi, Antonella, Menichincheri, Maria, Molinari, Antonio, Montagnoli, Alessia, Pillan, Antonio, Rainoldi, Sonia, Sirtori, Federico Riccardi, Sola, Francesco, Thieffine, Sandrine, Tibolla, Marcellino, Valsasina, Barbara, Volpi, Daniele, Santocanale, Corrado, Vanotti, Ermes

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First Cdc7 Kinase Inhibitors: Pyrrolopyridinones as Potent and Orally Active Antitumor Agents. 2. Lead Discovery by Menichincheri, Maria, Bargiotti, Alberto, Berthelsen, Jens, Bertrand, Jay A, Bossi, Roberto, Ciavolella, Antonella, Cirla, Alessandra, Cristiani, Cinzia, Croci, Valter, D’Alessio, Roberto, Fasolini, Marina, Fiorentini, Francesco, Forte, Barbara, Isacchi, Antonella, Martina, Katia, Molinari, Antonio, Montagnoli, Alessia, Orsini, Paolo, Orzi, Fabrizio, Pesenti, Enrico, Pezzetta, Daniele, Pillan, Antonio, Poggesi, Italo, Roletto, Fulvia, Scolaro, Alessandra, Tatò, Marco, Tibolla, Marcellino, Valsasina, Barbara, Varasi, Mario, Volpi, Daniele, Santocanale, Corrado, Vanotti, Ermes

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Solid-phase synthesis of a small library of 3-phenylthio-3-nicotinyl propionic acid derivatives acting as antagonists of the integrin αVβ3 by Vianello, Paola, Cozzi, Paolo, Galvani, Arturo, Meroni, Maurizio, Varasi, Mario, Volpi, Daniele, Bandiera, Tiziano

“…We describe the synthesis of a series of low molecular weight inhibitors of the αvβ3 integrin obtained by modifying a high-throughput screening hit with…”
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Solid-phase synthesis of a small library of 3-phenylthio-3-nicotinyl propionic acid derivatives acting as antagonists of the integrin alphaVbeta3 by Vianello, Paola, Cozzi, Paolo, Galvani, Arturo, Meroni, Maurizio, Varasi, Mario, Volpi, Daniele, Bandiera, Tiziano

“…We describe the synthesis of a series of low molecular weight inhibitors of the alphavbeta3 integrin obtained by modifying a high-throughput screening hit with…”
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Endothelin-1-selective binding sites are downregulated by transforming growth factor-beta and upregulated by basic fibroblast growth factor in a vascular smooth muscle-derived cell line by Cristiani, C, Volpi, D, Landonio, A, Bertolero, F

“…Endothelins (ETs) elicit in vivo and in vitro a potent vasoconstrictor activity after binding to high-affinity receptors on vascular smooth muscle cells…”
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Agents Combining Thromboxane Receptor Antagonism with Thromboxane Synthase Inhibition: [[[2-(1H-Imidazol-1-yl)ethylidene]amino]oxy]alkanoic Acids by Cozzi, Paolo, Giordani, Antonio, Menichincheri, Maria, Pillan, Antonio, Pinciroli, Vittorio, Rossi, Arsenia, Tonani, Roberto, Volpi, Daniele, Tamburin, Monica

“…A new class of compounds combining thromboxane-A2 (TxA2) receptor antagonism and thromboxane synthase inhibition is described. A first series of (E)- and…”
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Inactivation of endothelin by polymorphonuclear leukocyte-derived lytic enzymes by PATRIGNANI, P, DEL MASCHIO, A, BAZZONI, G, DAFFONCHIO, L, HERNANDEZ, A, MODICA, R, MONTESANTI, L, VOLPI, D, PATRONO, C, DEJANA, E

“…Cultured bovine aortic endothelial cells (BAEC) released endothelin-1 (ET-1) in the culture medium in a time-dependent fashion. Coincubation of fMLP-activated…”
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