Search Results - "Volpe, Pompeo"

Molecular adaptation to calsequestrin 2 (CASQ2) point mutations leading to catecholaminergic polymorphic ventricular tachycardia (CPVT): comparative analysis of R33Q and D307H mutants by Valle, Giorgia, Arad, Michael, Volpe, Pompeo

“…Homozygous calsequestrin 2 (CASQ2) point mutations leads to catecholaminergic polymorphic ventricular tachycardia: a common pathogenetic feature appears to be…”
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Increased Homer Activity and NMJ Localization in the Vestibular Lesion het -/- Mouse soleus Muscle by Trautmann, Gabor, Block, Katharina, Gutsmann, Martina, Besnard, Stéphane, Furlan, Sandra, Denise, Pierre, Volpe, Pompeo, Blottner, Dieter, Salanova, Michele

“…We investigated the shuttling of Homer protein isoforms identified in soluble (cytosolic) vs. insoluble (membrane-cytoskeletal) fraction and Homer…”
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Gene Expression Profiling in Slow-Type Calf Soleus Muscle of 30 Days Space-Flown Mice by Gambara, Guido, Salanova, Michele, Ciciliot, Stefano, Furlan, Sandra, Gutsmann, Martina, Schiffl, Gudrun, Ungethuem, Ute, Volpe, Pompeo, Gunga, Hanns-Christian, Blottner, Dieter

“…Microgravity exposure as well as chronic disuse are two main causes of skeletal muscle atrophy in animals and humans. The antigravity calf soleus is a…”
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Opposite Regulation of Homer Signal at the NMJ Postsynaptic Micro Domain between Slow- and Fast-Twitch Muscles in an Experimentally Induced Autoimmune Myasthenia Gravis (EAMG) Mouse Model by Schubert, Martin, Pelz, Andreas, Trautmann, Gabor, Block, Katharina, Furlan, Sandra, Gutsmann, Martina, Kohler, Siegfried, Volpe, Pompeo, Blottner, Dieter, Meisel, Andreas, Salanova, Michele

“…Accelerated postsynaptic remodelling and disturbance of neuromuscular transmission are common features of autoimmune neurodegenerative diseases. Homer protein…”
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Reciprocal Homer1a and Homer2 Isoform Expression Is a Key Mechanism for Muscle Soleus Atrophy in Spaceflown Mice by Blottner, Dieter, Trautmann, Gabor, Furlan, Sandra, Gambara, Guido, Block, Katharina, Gutsmann, Martina, Sun, Lian-Wen, Worley, Paul F, Gorza, Luisa, Scano, Martina, Lorenzon, Paola, Vida, Imre, Volpe, Pompeo, Salanova, Michele

“…The molecular mechanisms of skeletal muscle atrophy under extended periods of either disuse or microgravity are not yet fully understood. The transition of…”
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Reorganized stores and impaired calcium handling in skeletal muscle of mice lacking calsequestrin-1 by Paolini, Cecilia, Quarta, Marco, Nori, Alessandra, Boncompagni, Simona, Canato, Marta, Volpe, Pompeo, Allen, Paul D., Reggiani, Carlo, Protasi, Feliciano

“…Calsequestrin (CS), the major Ca 2+ -binding protein in the sarcoplasmic reticulum (SR), is thought to play a dual role in excitation–contraction coupling:…”
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Homer protein family regulation in skeletal muscle and neuromuscular adaptation by Salanova, Michele, Volpe, Pompeo, Blottner, Dieter

“…Scaffolding adaptor proteins of the Homer family have recently been implicated in regulation of a large number of physiological processes owing to their…”
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Calsequestrins New Calcium Store Markers of Adult Zebrafish Cerebellum and Optic Tectum by Furlan, Sandra, Campione, Marina, Murgia, Marta, Mosole, Simone, Argenton, Francesco, Volpe, Pompeo, Nori, Alessandra

“…Calcium stores in neurons are heterogeneous in compartmentalization and molecular composition. (zebrafish) is an animal model with a simply folded cerebellum…”
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Luminal Ca2+ regulation of single cardiac ryanodine receptors: insights provided by calsequestrin and its mutants by Qin, Jia, Valle, Giorgia, Nani, Alma, Nori, Alessandra, Rizzi, Nicoletta, Priori, Silvia G, Volpe, Pompeo, Fill, Michael

“…The luminal Ca2+ regulation of cardiac ryanodine receptor (RyR2) was explored at the single channel level. The luminal Ca2+ and Mg2+ sensitivity of single…”
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Microgravity-Induced Transcriptome Adaptation in Mouse Paraspinal longissimus dorsi Muscle Highlights Insulin Resistance-Linked Genes by Gambara, Guido, Salanova, Michele, Ciciliot, Stefano, Furlan, Sandra, Gutsmann, Martina, Schiffl, Gudrun, Ungethuem, Ute, Volpe, Pompeo, Gunga, Hanns-Christian, Blottner, Dieter

“…Microgravity as well as chronic muscle disuse are two causes of low back pain originated at least in part from paraspinal muscle deconditioning. At present no…”
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Decreased RyR2 refractoriness determines myocardial synchronization of aberrant Ca²⁺ release in a genetic model of arrhythmia by Brunello, Lucia, Slabaugh, Jessica L., Radwański, Przemysław B., Ho, Hsiang-Ting, Belevych, Andriy E., Lou, Qing, Chen, Haiyan, Napolitano, Carlo, Lodola, Francesco, Priori, Silvia G., Fedorov, Vadim V., Volpe, Pompeo, Fill, Michael, Janssen, Paul M. L., Györke, Sándor

“…Dysregulated intracellular Ca²⁺ signaling is implicated in a variety of cardiac arrhythmias, including catecholaminergic polymorphic ventricular tachycardia…”
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Gene Transfer of Engineered Calmodulin Alleviates Ventricular Arrhythmias in a Calsequestrin‐Associated Mouse Model of Catecholaminergic Polymorphic Ventricular Tachycardia by Liu, Bin, Walton, Shane D., Ho, Hsiang‐Ting, Belevych, Andriy E., Tikunova, Svetlana B., Bonilla, Ingrid, Shettigar, Vikram, Knollmann, Bjorn C., Priori, Silvia G., Volpe, Pompeo, Radwański, Przemysław B., Davis, Jonathan P., Györke, Sándor

“…Background Catecholaminergic polymorphic ventricular tachycardia (CPVT) is a familial arrhythmogenic syndrome characterized by sudden death. There are several…”
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Nitrosative Stress in Astronaut Skeletal Muscle in Spaceflight by Blottner, Dieter, Moriggi, Manuela, Trautmann, Gabor, Furlan, Sandra, Block, Katharina, Gutsmann, Martina, Torretta, Enrica, Barbacini, Pietro, Capitanio, Daniele, Rittweger, Joern, Limper, Ulrich, Volpe, Pompeo, Gelfi, Cecilia, Salanova, Michele

“…Long-duration mission (LDM) astronauts from the International Space Station (ISS) (>180 ISS days) revealed a close-to-normal sarcolemmal nitric oxide synthase…”
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Effects of Electrical Stimulation on Skeletal Muscle of Old Sedentary People by Mosole, Simone, Zampieri, Sandra, Furlan, Sandra, Carraro, Ugo, Löefler, Stefan, Kern, Helmut, Volpe, Pompeo, Nori, Alessandra

“…Physical activity plays an important role in preventing muscle atrophy and chronic diseases in adults and in the elderly. Calcium (Ca2+) cycling and activation…”
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Nitrosative Redox Homeostasis and Antioxidant Response Defense in Disused Vastus lateralis Muscle in Long-Term Bedrest (Toulouse Cocktail Study) by Blottner, Dieter, Capitanio, Daniele, Trautmann, Gabor, Furlan, Sandra, Gambara, Guido, Moriggi, Manuela, Block, Katharina, Barbacini, Pietro, Torretta, Enrica, Py, Guillaume, Chopard, Angèle, Vida, Imre, Volpe, Pompeo, Gelfi, Cecilia, Salanova, Michele

“…Increased oxidative stress by reactive oxygen species (ROS) and reactive nitrogen species (RNS) is a major determinant of disuse-induced muscle atrophy. Muscle…”
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Calsequestrin Determines the Functional Size and Stability of Cardiac Intracellular Calcium Stores: Mechanism for Hereditary Arrhythmia by Terentyev, Dmitry, Viatchenko-Karpinski, Serge, Györke, Inna, Volpe, Pompeo, Williams, Simon C., Györke, Sandor

“…Calsequestrin is a high-capacity Ca-binding protein expressed inside the sarcoplasmic reticulum (SR), an intracellular Ca release and storage organelle in…”
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Expression and regulation of Homer in human skeletal muscle during neuromuscular junction adaptation to disuse and exercise by Salanova, Michele, Bortoloso, Elena, Schiffl, Gudrun, Gutsmann, Martina, Belavy, Daniel L., Felsenberg, Dieter, Furlan, Sandra, Volpe, Pompeo, Blottner, Dieter

“…ABSTRACT Protein calcium sensors of the Homer family have been proposed to modulate the activity of various ion channels and nuclear factor of activated T…”
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Tetrodotoxin-Sensitive Neuronal-Type Na + Channels: A Novel and Druggable Target for Prevention of Atrial Fibrillation by Munger, Mark A, Olğar, Yusuf, Koleske, Megan L, Struckman, Heather L, Mandrioli, Jessica, Lou, Qing, Bonila, Ingrid, Kim, Kibum, Ramos Mondragon, Roberto, Priori, Silvia G, Volpe, Pompeo, Valdivia, Héctor H, Biskupiak, Joseph, Carnes, Cynthia A, Veeraraghavan, Rengasayee, Györke, Sándor, Radwański, Przemysław B

“…Background Atrial fibrillation (AF) is a comorbidity associated with heart failure and catecholaminergic polymorphic ventricular tachycardia. Despite the Ca…”
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Altered Ca2+ concentration, permeability and buffering in the myofibre Ca2+ store of a mouse model of malignant hyperthermia by Manno, Carlo, Figueroa, Lourdes, Royer, Leandro, Pouvreau, Sandrine, Lee, Chang Seok, Volpe, Pompeo, Nori, Alessandra, Zhou, Jingsong, Meissner, Gerhard, Hamilton, Susan L., Ríos, Eduardo

“…Key points •  Malignant Hyperthermia (MH) affects the Ca2+ movements that control muscle contraction. We measured Ca2+ movements in skeletal muscle of “Y522S”…”
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Calsequestrin (CASQ1) rescues function and structure of calcium release units in skeletal muscles of CASQ1-null mice by Tomasi, Mirta, Canato, Marta, Paolini, Cecilia, Dainese, Marco, Reggiani, Carlo, Volpe, Pompeo, Protasi, Feliciano, Nori, Alessandra

“…Amplitude of Ca(2+) transients, ultrastructure of Ca(2+) release units, and molecular composition of sarcoplasmic reticulum (SR) are altered in fast-twitch…”
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