Evaluation of the effects of sensorimotor exercise on physical and psychological parameters in breast cancer patients undergoing neurotoxic chemotherapy

Introduction Breast cancer is the most common cancer disease of women in industrialized countries. Neurotoxic chemotherapy drugs are known to harm peripheral nerves and cause a chemotherapy-induced peripheral neuropathy (CIPN). CIPN is one of the most common adverse events associated with Paclitaxel...

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Bibliographic Details
Published in:	Journal of cancer research and clinical oncology Vol. 144; no. 9; pp. 1785 - 1792
Main Authors:	Vollmers, Paul Lennart, Mundhenke, Christoph, Maass, Nicolai, Bauerschlag, Dirk, Kratzenstein, Stefan, Röcken, Christoph, Schmidt, Thorsten
Format:	Journal Article
Language:	English
Published:	Berlin/Heidelberg Springer Berlin Heidelberg 01-09-2018 Springer Nature B.V
Subjects:	Adult Aged Antineoplastic Agents - adverse effects Antineoplastic Agents - therapeutic use Balance Breast cancer Breast Neoplasms - drug therapy Breast Neoplasms - physiopathology Breast Neoplasms - psychology Cancer Research Case-Control Studies Chemotherapy Exercise - physiology Female Hematology Humans Immunoglobulins Internal Medicine Leg Medicine Medicine & Public Health Middle Aged Neurotoxicity Oncology Original Article – Clinical Oncology Paclitaxel Paclitaxel - therapeutic use Peripheral nerves Peripheral Nervous System Diseases - chemically induced Peripheral Nervous System Diseases - physiopathology Peripheral Nervous System Diseases - psychology Peripheral neuropathy Posture Quality of Life Sensorimotor Cortex - physiopathology Sensorimotor system Survivors Young Adult Chemotherapy-induced peripheral polyneuropathy European organization of research and treatment of cancer Posturometry Posturography Lower extremity Neuropathy Neurotoxic Hand dynamometer Mamma-carcinoma Training Adverse events Risk of falling BR-23 Paclitaxel Nerves Exercise intervention Fullterton Advanced Balance Scale Eortc Fall risk CIPN-20 Multidimensional Fatigue Inventory Monopedal stance Postural instability Taxol FAB Survivors Chair rising test Breast cancer Upper extremity Bipedal stance Qol Quality of life Chemotherapy Sway area Sensorimotor exercise QLQ-C30 MFI-20 Strength
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Summary:	Introduction Breast cancer is the most common cancer disease of women in industrialized countries. Neurotoxic chemotherapy drugs are known to harm peripheral nerves and cause a chemotherapy-induced peripheral neuropathy (CIPN). CIPN is one of the most common adverse events associated with Paclitaxel chemotherapy and may remain present long after the termination of chemotherapy. Thus, it reduces the patients’ quality of life (QoL) both during chemotherapy and onwards, and can impose a danger on breast cancer survivors due to an increased risk of falling and fall-related injuries. Methods The aim of this randomized-controlled trial (RCT) ( n = 36) (IG: intervention group, n = 17) (CG: control group, n = 19) was to determine whether sensorimotor exercises have a positive effect on physical and psychological parameters in breast cancer patients undergoing neurotoxic chemotherapy (Paclitaxel). Results As a result, we were able to show significant improvements in postural stability in monopedal stance [left leg 16.17 ± 3.67 vs. 21.55 ± 5.33 ( p < 0.001) and right leg 15.14 ± 2.30 vs. 20.85 ± 5.05 ( p < 0.001)] and in bipedal stance [T1 vs. T0, − 0.49 (IG) vs. + 1.14 (CG) p = 0.039]. Discussion These results in posturography correlate with the clinical presentation with intervention group patients scoring significantly better on the Fullerton Advanced Balance Scale [37.71 ± 2.73 vs. 34.47 ± 3.98 ( p = 0.004)]. Moderate strength training successfully prevented a strength loss in the IG that was remarkable in the CG (− 1.60 vs. 0.60, p = 0.029). Concerning the psychological parameters assessed via EORTC- and MFI-questionnaires, no significant improvements were found. Conclusion Future studies should focus on the correlation of clinical and posturometry findings and subjective QOL such as the long-term-development of CIPN.
ISSN:	0171-5216 1432-1335
DOI:	10.1007/s00432-018-2686-5