Search Results - "Vollmer, T L"

Prevalence and treatment of spasticity reported by multiple sclerosis patients by Rizzo, M A, Hadjimichael, O C, Preiningerova, J, Vollmer, T L

“…The objective of this study was to characterize the population of multiple sclerosis (MS) patients suffering from spasticity and to evaluate treatment…”
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Randomized multicenter trial of natalizumab in acute MS relapses: Clinical and MRI effects by O'CONNOR, P. W, GOODMAN, A, WILLMER-HULME, A. J, LIBONATI, M. A, METZ, L, MURRAY, R. S, SHEREMATA, W. A, VOLLMER, T. L, STONE, L. A

“…Relapses in multiple sclerosis (MS) can cause significant neurologic disability. Natalizumab (Antegren) is a humanized anti-alpha4-integrin antibody that…”
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The dynamic link between the integrity of the immune system and zinc status by Fraker, P J, King, L E, Laakko, T, Vollmer, T L

“…The results of more than three decades of work indicate that zinc deficiency rapidly diminishes antibody- and cell-mediated responses in both humans and…”
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CD4+ CD25+ regulatory T cells contribute to the therapeutic effects of glatiramer acetate in experimental autoimmune encephalomyelitis by Jee, Y, Piao, W.H, Liu, R, Bai, X.F, Rhodes, S, Rodebaugh, R, Campagnolo, D.I, Shi, F.D, Vollmer, T.L

“…Abstract CD4+ CD25+ regulatory T cells (Tregs) are potent immunosuppressors that are pivotal in the maintenance of self-tolerance. The involvement of Tregs in…”
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Proposed diagnostic criteria and nosology of acute transverse myelitis

“…Acute transverse myelitis (ATM) is a focal inflammatory disorder of the spinal cord, resulting in motor, sensory, and autonomic dysfunction. A set of uniform…”
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A randomized placebo-controlled phase III trial of oral laquinimod for multiple sclerosis by Vollmer, T. L., Sorensen, P. S., Selmaj, K., Zipp, F., Havrdova, E., Cohen, J. A., Sasson, N., Gilgun-Sherki, Y., Arnold, D. L.

“…The phase III placebo-controlled BRAVO study assessed laquinimod effects in patients with relapsing-remitting MS (RRMS), and descriptively compared laquinimod…”
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A safety and pharmacokinetic study of intravenous natalizumab in patients with MS by SHEREMATA, W. A, VOLLMER, T. L, STONE, L. A, WILLMER-HULME, A. J, KOLLER, M

“…A phase 1, randomized, placebo-controlled, five-level dose escalation safety and tolerability and pharmacokinetic study of a single IV dose of natalizumab was…”
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Transplantation of Cryopreserved Adult Human Schwann Cells Enhances Axonal Conduction in Demyelinated Spinal Cord by Kohama, Ikuhide, Lankford, Karen L, Preiningerova, Jana, White, Fletcher A, Vollmer, Timothy L, Kocsis, Jeffery D

“…Schwann cells derived from human sural nerve may provide a valuable source of tissue for a cell-based therapy in multiple sclerosis. However, it is essential…”
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An open-label safety and drug interaction study of natalizumab (Antegren™) in combination with interferon-beta (Avonex®) in patients with multiple sclerosis by Vollmer, T L, Phillips, J T, Goodman, A D, Agius, M A, Libonati, M A, Giacchino, J L, Grundy, J S

“…In this open-label drug-interaction trial, we studied 38 patients with relapsing-remitting multiple sclerosis (MS) who received 3.0 or 6.0 mg/kg of natalizumab…”
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APOE epsilon 4 allele is associated with cognitive impairment in patients with multiple sclerosis by Shi, J, Zhao, C B, Vollmer, T L, Tyry, T M, Kuniyoshi, S M

“…The role of apolipoprotein E (APOE) polymorphism has been well recognized in other cognitive neurodegenerative disorders, such as Alzheimer disease. Its role…”
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APOE ε4 allele is associated with cognitive impairment in patients with multiple sclerosis by SHI, J, ZHAO, C. B, VOLLMER, T. L, TYRY, T. M, KUNIYOSHI, S. M

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Neuromuscular responses of patients with multiple sclerosis by Rice, C L, Vollmer, T L, Bigland-Ritchie, B

“…Muscle weakness, studied in 4 patients with multiple sclerosis (MS), was compared with values from normal subjects. Twitch occlusion showed that normal…”
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Glatiramer Acetate‐Specific Antibody Titres in Patients with Relapsing / Remitting Multiple Sclerosis and in Experimental Autoimmune Encephalomyelitis by Bomprezzi, R., Schaefer, R., Reese, V., Misra, A., Vollmer, T. L., Kala, M.

“…Glatiramer acetate (GA) is an immunomodulatory drug approved for the treatment of clinically isolated syndrome (CIS) and relapsing/remitting multiple sclerosis…”
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IL-21 Modulates CD4⁺ CD25⁺ Regulatory T-Cell Homeostasis in Experimental Autoimmune Encephalomyelitis by Piao, W.-H, Jee, Y.H, Liu, R.L, Coons, S.W, Kala, M, Collins, M, Young, D.A, Campagnolo, D.I, Vollmer, T.L, Bai, X.-F, La Cava, A, Shi, F.-D

“…The homeostasis of CD4 ⁺ CD25 ⁺ regulatory T cells (Tregs) depends on the cytokine interleukin (IL)-2. As IL-21 shares sequence homology with IL-2 and the…”
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Ocular myasthenia: a protean disorder by Weinberg, D A, Lesser, R L, Vollmer, T L

“…Ocular myasthenia is a localized form of myasthenia clinically involving only the extraocular, levator palpebrae superioris, and/or orbicularis oculi muscles…”
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A new EAE model of brain demyelination induced by intracerebroventricular pertussis toxin by Zhao, C.B., Coons, S.W., Cui, M., Shi, F.D., Vollmer, T.L., Ma, C.Y., Kuniyoshi, S.M., Shi, J.

“…Experimental autoimmune encephalomyelitis (EAE) is a primary animal model of multiple sclerosis (MS). MS predominantly presents with evidence of lesions in the…”
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Depletion of T-4+ lymphocytes with monoclonal antibody reactivates toxoplasmosis in the central nervous system: a model of superinfection in AIDS by Vollmer, TL, Waldor, MK, Steinman, L, Conley, FK

“…Central nervous system toxoplasmosis causes disability and death in up to 30% of patients with acquired immune deficiency syndrome (AIDS). The source of the…”
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Differential Effects of IL-21 during Initiation and Progression of Autoimmunity against Neuroantigen by Vollmer, Timothy L, Liu, Ruolan, Price, Mary, Rhodes, Susan, La Cava, Antonio, Shi, Fu-Dong

“…The cytokine IL-21 is closely related to IL-2 and IL-15, a cytokine family that uses the common gamma-chain for signaling. IL-21 is expressed by activated…”
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Lhermitte's sign in a patient with herpes zoster by Vollmer, T L, Brass, L M, Waxman, S G

“…A 34-year-old, previously healthy man developed herpes zoster (shingles) involving the C4 dermatome. This was accompanied by Lhermitte's sign, i.e. an electric…”
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Cooperation of invariant NKT cells and CD4+CD25+ T regulatory cells in the prevention of autoimmune myasthenia by Liu, R., La Cava, A., Bai, X.-F., Jee, Y., Price, M., Campagnolo, D. I., Christadoss, P., Vollmer, T. L., Van Kaer, L., Shi, F.-D.

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