Search Results - "Volkman, Hannah E."

Tight nuclear tethering of cGAS is essential for preventing autoreactivity by Volkman, Hannah E, Cambier, Stephanie, Gray, Elizabeth E, Stetson, Daniel B

“…cGAS is an intracellular innate immune sensor that detects double-stranded DNA. The presence of billions of base pairs of genomic DNA in all nucleated cells…”
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Intracellular Nucleic Acid Detection in Autoimmunity by Crowl, John T, Gray, Elizabeth E, Pestal, Kathleen, Volkman, Hannah E, Stetson, Daniel B

“…Protective immune responses to viral infection are initiated by innate immune sensors that survey extracellular and intracellular space for foreign nucleic…”
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Tumor Necrosis Factor Signaling Mediates Resistance to Mycobacteria by Inhibiting Bacterial Growth and Macrophage Death by Clay, Hilary, Volkman, Hannah E., Ramakrishnan, Lalita

“…Tumor necrosis factor (TNF), a key effector in controlling tuberculosis, is thought to exert protection by directing formation of granulomas, organized…”
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Mycobacterium marinum Infection of Adult Zebrafish Causes Caseating Granulomatous Tuberculosis and Is Moderated by Adaptive Immunity by Swaim, Laura E, Connolly, Lynn E, Volkman, Hannah E, Humbert, Olivier, Born, Donald E, Ramakrishnan, Lalita

“…The zebrafish, a genetically tractable model vertebrate, is naturally susceptible to tuberculosis caused by Mycobacterium marinum, a close genetic relative of…”
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Tuberculous granuloma formation is enhanced by a mycobacterium virulence determinant by Volkman, Hannah E, Clay, Hilary, Beery, Dana, Chang, Jennifer C W, Sherman, David R, Ramakrishnan, Lalita

“…Granulomas are organized host immune structures composed of tightly interposed macrophages and other cells that form in response to a variety of persistent…”
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The enemy within: endogenous retroelements and autoimmune disease by Volkman, Hannah E, Stetson, Daniel B

“…Inappropriate or chronic detection of self nucleic acids by the innate immune system underlies many human autoimmune diseases. We discuss here an unexpected…”
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Tuberculous Granuloma Induction via Interaction of a Bacterial Secreted Protein with Host Epithelium by Volkman, Hannah E, Pozos, Tamara C, Zheng, John, Davis, J. Muse, Rawls, John F, Ramakrishnan, Lalita

“…Granulomas, organized aggregates of immune cells, are a hallmark of tuberculosis and have traditionally been thought to restrict mycobacterial growth. However,…”
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Computational design of constitutively active cGAS by Dowling, Quinton M., Volkman, Hannah E., Gray, Elizabeth E., Ovchinnikov, Sergey, Cambier, Stephanie, Bera, Asim K., Sankaran, Banumathi, Johnson, Max R., Bick, Matthew J., Kang, Alex, Stetson, Daniel B., King, Neil P.

“…Cyclic GMP–AMP synthase (cGAS) is a pattern recognition receptor critical for the innate immune response to intracellular pathogens, DNA damage, tumorigenesis…”
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TNF signaling mediates resistance to mycobacteria by inhibiting bacterial growth and macrophage death but not tuberculous granuloma formation by Clay, Hilary, Volkman, Hannah E., Ramakrishnan, Lalita

“…Tumor necrosis factor (TNF), a key effector in controlling tuberculosis, is thought to exert protection by directing formation of granulomas, organized…”
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The Mycobacterium marinum RD1 locus promotes virulence and macrophage aggregation into tuberculous granulomas by enhancing induction of host matrix metalloproteinase 9 in proximal epithelial cells (133.19) by Volkman, Hannah E, Pozos, Tamara, Zheng, John, Rawls, John F, Ramakrishnan, Lalita

“…Granulomas are organized aggregates of differentiated macrophages and other immune cells that form in response to mycobacterial infection and other persistent…”
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Mycobacterium marinum Infection of Adult Zebrafish Causes Caseating Granulomatous Tuberculosis and Is Moderated by Adaptive Immunity by Swaim, Laura E., Connolly, Lynn E., Volkman, Hannah E., Humbert, Olivier, Born, Donald E., Ramakrishnan, Lalita

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Early host -pathogen interactions involved in tuberculous granuloma formation by Volkman, Hannah E

“…Tuberculosis is caused by pathogenic mycobacteria, which infect and reside within host macrophages. Pathogenesis includes recruitment of macrophages to initial…”
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Early host-pathogen interactions involved in tuberculous granuloma formation by Volkman, Hannah E

“…Tuberculosis is caused by pathogenic mycobacteria, which infect and reside within host macrophages. Pathogenesis includes recruitment of macrophages to initial…”
Get full text