Search Results - "Volkert, Wynn A"

In Vivo Imaging of Human Colorectal Cancer Using Radiolabeled Analogs of the Uroguanylin Peptide Hormone by DIJIE LIU, OVERBEY, Douglas, WATKINSON, Lisa D, DAIBES-FIGUEROA, Said, HOFFMAN, Timothy J, FORTE, Leonard R, VOLKERT, Wynn A, GIBLIN, Michael F

“…Background: Uroguanylin is an endogenous peptide agonist that binds to the guanylate cyclase C receptor (GC-C). GC-C is overexpressed in human colorectal…”
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Microimaging Characterization of a B16-F10 Melanoma Metastasis Mouse Model by Winkelmann, Christopher T., Figueroa, Said Daibes, Rold, Tammy L., Volkert, Wynn A., Hoffman, Timothy J.

“…Metastatic mouse models of melanoma have been characterized by gross necropsy examination, histopathology, and optical imaging. To determine if the time…”
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Evaluation of the Pharmacokinetic Effects of Various Linking Group Using the 111In-DOTA-X-BBN(7−14)NH2 Structural Paradigm in a Prostate Cancer Model by Garrison, Jered C, Rold, Tammy L, Sieckman, Gary L, Naz, Farah, Sublett, Samantha V, Figueroa, Said Daibes, Volkert, Wynn A, Hoffman, Timothy J

“…The high incidence of BB2 receptor (BB2r) expression in various cancers has prompted investigators to pursue the development of BB2r-targeted agents for…”
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Therapeutic Radiopharmaceuticals by Volkert, Wynn A., Hoffman, Timothy J.

“…Volkert and Hoffman discuss some of the considerations involved in identifying the radionuclides that hold potential for the development of radioactive…”
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Selective Targeting of E. coli Heat-stable Enterotoxin Analogs to Human Colon Cancer Cells by GIBLIN, Michael F, SIECKMAN, Gary L, WATKINSON, Lisa D, DAIBES-FIGUEROA, Said, HOFFMAN, Timothy J, FORTE, Leonard R, VOLKERT, Wynn A

“…Background: Radiolabeled analogs of the E. coli heat-stable enterotoxin (ST h ) are currently under study as imaging and therapeutic agents for colorectal…”
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Radiolabeled peptide conjugates for targeting of the bombesin receptor superfamily subtypes by Smith, Charles J., Volkert, Wynn A., Hoffman, Timothy J.

“…Research laboratories around the world are currently focusing their efforts toward the development of radiometallated, site-directed, diagnostic/therapeutic…”
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True radiotracers: are we approaching theoretical specific activity with Tc-99m and I-123? by Eckelman, William C, Bonardi, Mauro, Volkert, Wynn A

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Design and Synthesis of a Bombesin Peptide-Conjugated Tripodal Phosphino Dithioether Ligand Topology for the Stabilization of the fac-[M(CO)3]+ Core (M = 99 mTc or Re) by Kannan, Raghuraman, Pillarsetty, Nagavarakishore, Gali, Hariprasad, Hoffman, Timothy J, Barnes, Charles L, Jurisson, Silvia S, Smith, Charles J, Volkert, Wynn A

“…A new tumor-seeking tridentate topology consisting of a phosphino dithioether ((HOCH2)2PCH2CH2S(CH2) n CH2SR; PS2) ligand framework for the production of…”
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Radiochemical investigations of gastrin-releasing peptide receptor-specific [(99m)Tc(X)(CO)3-Dpr-Ser-Ser-Ser-Gln-Trp-Ala-Val-Gly-His-Leu-Met-(NH2)] in PC-3, tumor-bearing, rodent models: syntheses, radiolabeling, and in vitro/in vivo studies where Dpr = 2,3-diaminopropionic acid and X = H2O or P(CH2OH)3 by Smith, C Jeffrey, Sieckman, Gary L, Owen, Nellie K, Hayes, Donald L, Mazuru, Dana G, Kannan, Raghuraman, Volkert, Wynn A, Hoffman, Timothy J

“…Bombesin (BBN), a 14 amino acid peptide, is an analogue of human gastrin-releasing peptide (GRP) that binds to GRP receptors (GRPrs) with high affinity and…”
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TLD assessment of mouse dosimetry during microCT imaging by Figueroa, Said Daibes, Winkelmann, Christopher T., Miller, William H., Volkert, Wynn A., Hoffman, Timothy J.

“…Advances in laboratory animal imaging have provided new resources for noninvasive biomedical research. Among these technologies is microcomputed tomography…”
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In Vitro and In Vivo Evaluation of Alexa Fluor 680-Bombesin[7–14]NH2 Peptide Conjugate, a High-Affinity Fluorescent Probe with High Selectivity for the Gastrin-Releasing Peptide Receptor by Ma, Lixin, Yu, Ping, Veerendra, Bhadrasetty, Rold, Tammy L., Retzloff, Lauren, Prasanphanich, Adam, Sieckman, Gary, Hoffman, Timothy J., Volkert, Wynn A., Smith, Charles J.

“…Gastrin-releasing peptide (GRP) receptors are overexpressed on several types of human cancer cells, including breast, prostate, small cell lung, and pancreatic…”
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In Vitro and in Vivo Antitumor Properties of Tetrakis((trishydroxy- methyl)phosphine)gold(I) Chloride by Pillarsetty, Nagavarakishore, Katti, Kavita K, Hoffman, Timothy J, Volkert, Wynn A, Katti, Kattesh V, Kamei, Hideo, Koide, Tatsurou

“…A novel hydrophilic gold compound, tetrakis((trishydroxymethyl)phosphine)gold(I) chloride 1, has been investigated for its antitumor properties. In vitro…”
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Comparative Evaluation of Three 64Cu-Labeled E. coli Heat-Stable Enterotoxin Analogues for PET Imaging of Colorectal Cancer by Liu, Dijie, Overbey, Douglas, Watkinson, Lisa D, Smith, Charles J, Daibes-Figueroa, Said, Hoffman, Timothy J, Forte, Leonard R, Volkert, Wynn A, Giblin, Michael F

“…Analogues of the E. coli heat-stable enterotoxin (STh) are currently under study as both imaging and therapeutic agents for colorectal cancer. Studies have…”
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Radiochemical investigations of [188Re(H2O)(CO)3-diaminopropionic acid-SSS-bombesin(7-14)NH2]: syntheses, radiolabeling and in vitro/in vivo GRP receptor targeting studies by Smith, C Jeffrey, Sieckman, Gary L, Owen, Nellie K, Hayes, Donald L, Mazuru, Dana G, Volkert, Wynn A, Hoffman, Timothy J

“…Bombesin (BBN), a 14 amino acid peptide, is an analogue of human gastrin-releasing peptide (GRP) that binds to GRP receptors (GRPr) with high affinity and…”
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Pm-149 DOTA bombesin analogs for potential radiotherapy in vivo comparison with Sm-153 and Lu-177 labeled DO3A-amideβAla-BBN(7-14)NH2 by FANG HU, CUTLER, Cathy S, HOFFMAN, Timothy, SIECKMAN, Gary, VOLKERT, Wynn A, JURISSON, Silvia S

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Chemistry of Bifunctional Photoprobes. 6. Synthesis and Characterization of High Specific Activity Metalated Photochemical Probes: Development of Novel Rhenium Photoconjugates of Human Serum Albumin and Fab Fragments by Rajagopalan, Raghavan, Kuntz, Robert R, Sharma, Uday, Volkert, Wynn A, Pandurangi, Raghoottama S

“…Functionalization of perfluoro aryl azides by bifunctional chelating agents (BFCAs) capable of forming high specific activity complexes with 99mTc (for…”
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Chemical and Biomedical Motifs of the Reactions of Hydroxymethylphosphines with Amines, Amino Acids, and Model Peptides by Berning, Douglas E, Katti, Kattesh V, Barnes, Charles L, Volkert, Wynn A

“…The reactions of tris(hydroxymethyl)phosphine (THP, 1), 1,2-bis(bis(hydroxymethyl)phosphino)benzene (HMPB, 2), and 1,2-bis(bis(hydroxymethyl)phosphino)ethane…”
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Exceptional Kinetic Propensity of Hydroxymethyl Phosphanes toward Rh(III) Stabilization in Water by Raghuraman, Kannan, Pillarsetty, Nagavarakishore, Volkert, Wynn A, Barnes, Charles, Jurisson, Silvia, Katti, Kattesh V

“…The reactions of (HOCH2)2P(C6H4)P(CH2OH)2 (HMPB) and P(CH2OH)3 (THP) with RhCl3·xH2O in aqueous media gave water-soluble complexes…”
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In vitro and in vivo evaluation of 111In-labeled E. coli heat-stable enterotoxin analogs for specific targeting of human breast cancers by GIBLIN, Michael F, GALI, Hariprasad, SIECKMAN, Gary L, OWEN, Nellie K, HOFFMAN, Timothy J, VOLKERT, Wynn A, FORTE, Leonard R

“…Research into the interaction between the E. coli heat-stable enterotoxin (STh) and the guanylin receptor guanylate cyclase C (GC-C) has generated >100…”
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In vitro and in vivo evaluation of 177Lu- and 90Y-labeled E. coli heat-stable enterotoxin for specific targeting of uroguanylin receptors on human colon cancers by Giblin, Michael F., Sieckman, Gary L., Shelton, Tiffani D., Hoffman, Timothy J., Forte, Leonard R., Volkert, Wynn A.

“…The human E. coli heat-stable enterotoxin (ST h, amino acid sequence N 1SSNYCCELCCNPACTGCY 19) binds specifically to the guanylate cyclase C (GC-C) receptor,…”
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