Search Results - "Volcho, Konstantin P."

Inhibition of DNA Repair Enzymes as a Valuable Pharmaceutical Approach by Volcho, Konstantin P, Lavrik, Olga I

“…The DNA repair system plays a crucial role in maintaining the integrity of the genome [...]…”
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A New Stereoselective Approach to the Substitution of Allyl Hydroxy Group in para-Mentha-1,2-diol in the Search for New Antiparkinsonian Agents by Podturkina, Alexandra V., Ardashov, Oleg V., Volcho, Konstantin P., Salakhutdinov, Nariman F.

“…Two approaches to the synthesis of para-menthene epoxide ((1S,5S,6R)-4) are developed. The first approach includes a reaction between chlorohydrin 7 and NaH in…”
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Neuroregeneration in Parkinson's Disease: From Proteins to Small Molecules by Sidorova, Yulia A, Volcho, Konstantin P, Salakhutdinov, Nariman F

“…Background: Parkinson’s disease (PD) is the second most common neurodegenerative disorder worldwide, the lifetime risk of developing this disease is 1.5%…”
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New 5-Hydroxycoumarin-Based Tyrosyl-DNA Phosphodiesterase I Inhibitors Sensitize Tumor Cell Line to Topotecan by Khomenko, Tatyana M, Zakharenko, Alexandra L, Kornienko, Tatyana E, Chepanova, Arina A, Dyrkheeva, Nadezhda S, Artemova, Anastasia O, Korchagina, Dina V, Achara, Chigozie, Curtis, Anthony, Reynisson, Jóhannes, Volcho, Konstantin P, Salakhutdinov, Nariman F, Lavrik, Olga I

“…Tyrosyl-DNA-phosphodiesterase 1 (TDP1) is an important enzyme in the DNA repair system. The ability of the enzyme to repair DNA damage induced by a…”
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New Inhibitors of Respiratory Syncytial Virus (RSV) Replication Based on Monoterpene-Substituted Arylcoumarins by Khomenko, Tatyana M, Shtro, Anna A, Galochkina, Anastasia V, Nikolaeva, Yulia V, Garshinina, Anzhelika V, Borisevich, Sophia S, Korchagina, Dina V, Volcho, Konstantin P, Salakhutdinov, Nariman F

“…Respiratory syncytial virus (RSV) causes annual epidemics of respiratory infection. Usually harmless to adults, the RSV infection can be dangerous to children…”
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New Dual Inhibitors of Tyrosyl-DNA Phosphodiesterase 1 and 2 Based on Deoxycholic Acid: Design, Synthesis, Cytotoxicity, and Molecular Modeling by Salomatina, Oksana V, Kornienko, Tatyana E, Zakharenko, Alexandra L, Komarova, Nina I, Achara, Chigozie, Reynisson, Jóhannes, Salakhutdinov, Nariman F, Lavrik, Olga I, Volcho, Konstantin P

“…Deoxycholic acid derivatives containing various heterocyclic functional groups at C-3 on the steroid scaffold were designed and synthesized as promising dual…”
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Pharmacokinetics and Dose Proportionality Study of a Novel Antiparkinsonian Agent, a 1H-1,2,4-Triazol-3-ylthio-conjugate of Prottremine by Gorina, Daria S, Lastovka, Anastasiya V, Rogachev, Artem D, Podturkina, Alexandra V, Pavlova, Alla V, Ardashov, Oleg V, Li-Zhulanov, Nikolai S, Tolstikova, Tatyana G, Volcho, Konstantin P, Salakhutdinov, Nariman F

“…The novel antiparkinsonian agent PA-96 is the focus of our research. PA-96 supported the survival of cultured naïve dopamine neurons, alleviated motor deficits…”
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Monoterpene-Containing Substituted Coumarins as Inhibitors of Respiratory Syncytial Virus (RSV) Replication by Khomenko, Tatyana M, Shtro, Anna A, Galochkina, Anastasia V, Nikolaeva, Yulia V, Petukhova, Galina D, Borisevich, Sophia S, Korchagina, Dina V, Volcho, Konstantin P, Salakhutdinov, Nariman F

“…Respiratory syncytial virus (RSV) is a critical cause of infant mortality. However, there are no vaccines and adequate drugs for its treatment. We showed, for…”
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On Associations between Fear-Induced Aggression, Bdnf Transcripts, and Serotonin Receptors in the Brains of Norway Rats: An Influence of Antiaggressive Drug TC-2153 by Moskaliuk, Vitalii S, Kozhemyakina, Rimma V, Khomenko, Tatyana M, Volcho, Konstantin P, Salakhutdinov, Nariman F, Kulikov, Alexander V, Naumenko, Vladimir S, Kulikova, Elizabeth A

“…The (brain-derived neurotrophic factor) gene contains eight regulatory exons (I-VIII) alternatively spliced to the protein-coding exon IX. Only exons I, II,…”
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New Hydrazinothiazole Derivatives of Usnic Acid as Potent Tdp1 Inhibitors by Filimonov, Aleksander S, Chepanova, Arina A, Luzina, Olga A, Zakharenko, Alexandra L, Zakharova, Olga D, Ilina, Ekaterina S, Dyrkheeva, Nadezhda S, Kuprushkin, Maxim S, Kolotaev, Anton V, Khachatryan, Derenik S, Patel, Jinal, Leung, Ivanhoe K H, Chand, Raina, Ayine-Tora, Daniel M, Reynisson, Johannes, Volcho, Konstantin P, Salakhutdinov, Nariman F, Lavrik, Olga I

“…Tyrosyl-DNA phosphodiesterase 1 (Tdp1) is a promising therapeutic target in cancer therapy. Combination chemotherapy using Tdp1 inhibitors as a component can…”
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Design, Synthesis, and Biological Investigation of Novel Classes of 3-Carene-Derived Potent Inhibitors of TDP1 by Il'ina, Irina V, Dyrkheeva, Nadezhda S, Zakharenko, Alexandra L, Sidorenko, Alexander Yu, Li-Zhulanov, Nikolay S, Korchagina, Dina V, Chand, Raina, Ayine-Tora, Daniel M, Chepanova, Arina A, Zakharova, Olga D, Ilina, Ekaterina S, Reynisson, Jóhannes, Malakhova, Anastasia A, Medvedev, Sergey P, Zakian, Suren M, Volcho, Konstantin P, Salakhutdinov, Nariman F, Lavrik, Olga I

“…Two novel structural types of tyrosyl-DNA phosphodiesterase 1 (TDP1) inhibitors with hexahydroisobenzofuran and 3-oxabicyclo [3.3.1]nonane scaffolds were…”
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Promising New Inhibitors of Tyrosyl-DNA Phosphodiesterase I (Tdp 1) Combining 4-Arylcoumarin and Monoterpenoid Moieties as Components of Complex Antitumor Therapy by Khomenko, Tatyana M, Zakharenko, Alexandra L, Chepanova, Arina A, Ilina, Ekaterina S, Zakharova, Olga D, Kaledin, Vasily I, Nikolin, Valeriy P, Popova, Nelly A, Korchagina, Dina V, Reynisson, Jóhannes, Chand, Raina, Ayine-Tora, Daniel M, Patel, Jinal, Leung, Ivanhoe K H, Volcho, Konstantin P, Salakhutdinov, Nariman F, Lavrik, Olga I

“…Tyrosyl-DNA phosphodiesterase 1 (Tdp1) is an important DNA repair enzyme in humans, and a current and promising inhibition target for the development of new…”
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Novel TDP1 Inhibitors: Disubstituted Thiazolidine-2,4-Diones Containing Monoterpene Moieties by Ivankin, Dmitry I, Kornienko, Tatyana E, Mikhailova, Marina A, Dyrkheeva, Nadezhda S, Zakharenko, Alexandra L, Achara, Chigozie, Reynisson, Jóhannes, Golyshev, Victor M, Luzina, Olga A, Volcho, Konstantin P, Salakhutdinov, Nariman F, Lavrik, Olga I

“…Tyrosyl-DNA-phosphodiesterase 1 (TDP1) is a promising target for antitumor therapy; the use of TDP1 inhibitors with a topoisomerase 1 poison such as topotecan…”
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Novel Tdp1 Inhibitors Based on Adamantane Connected with Monoterpene Moieties via Heterocyclic Fragments by Munkuev, Aldar A., Mozhaitsev, Evgenii S., Chepanova, Arina A., Suslov, Evgeniy V., Korchagina, Dina V., Zakharova, Olga D., Ilina, Ekaterina S., Dyrkheeva, Nadezhda S., Zakharenko, Alexandra L., Reynisson, Jóhannes, Volcho, Konstantin P., Salakhutdinov, Nariman F., Lavrik, Olga I.

“…Tyrosyl-DNA phosphodiesterase 1 (Tdp1) is a promising target for anticancer therapy due to its ability to counter the effects topoisomerase 1 (Top1) poison,…”
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Discovery of Novel Sultone Fused Berberine Derivatives as Promising Tdp1 Inhibitors by Gladkova, Elizaveta D, Chepanova, Arina A, Ilina, Ekaterina S, Zakharenko, Alexandra L, Reynisson, Jóhannes, Luzina, Olga A, Volcho, Konstantin P, Lavrik, Olga I, Salakhutdinov, Nariman F

“…A new type of berberine derivatives was obtained by the reaction of berberrubine with aliphatic sulfonyl chlorides. The new polycyclic compounds have a sultone…”
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New Deoxycholic Acid Derived Tyrosyl-DNA Phosphodiesterase 1 Inhibitors Also Inhibit Tyrosyl-DNA Phosphodiesterase 2 by Salomatina, Oksana V, Dyrkheeva, Nadezhda S, Popadyuk, Irina I, Zakharenko, Alexandra L, Ilina, Ekaterina S, Komarova, Nina I, Reynisson, Jóhannes, Salakhutdinov, Nariman F, Lavrik, Olga I, Volcho, Konstantin P

“…A series of deoxycholic acid (DCA) amides containing benzyl ether groups on the steroid core were tested against the tyrosyl-DNA phosphodiesterase 1 (TDP1) and…”
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Novel Bispidine-Monoterpene Conjugates-Synthesis and Application as Ligands for the Catalytic Ethylation of Chalcones by Suslov, Evgeniy V, Ponomarev, Konstantin Y, Patrusheva, Oxana S, Kuranov, Sergey O, Okhina, Alina A, Rogachev, Artem D, Munkuev, Aldar A, Ottenbacher, Roman V, Dalinger, Alexander I, Kalinin, Mikhail A, Vatsadze, Sergey Z, Volcho, Konstantin P, Salakhutdinov, Nariman F

“…A number of new chiral bispidines containing monoterpenoid fragments have been obtained. The bispidines were studied as ligands for Ni-catalyzed addition of…”
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A Newly Identified Monoterpenoid-Based Small Molecule Able to Support the Survival of Primary Cultured Dopamine Neurons and Alleviate MPTP-Induced Toxicity In Vivo by Kotliarova, Anastasiia, Podturkina, Alexandra V, Pavlova, Alla V, Gorina, Daria S, Lastovka, Anastasiya V, Ardashov, Oleg V, Rogachev, Artem D, Izyurov, Arseniy E, Arefieva, Alla B, Kulikov, Alexander V, Tolstikova, Tatyana G, Volcho, Konstantin P, Salakhutdinov, Nariman F, Sidorova, Yulia

“…Parkinson's disease (PD) is the most common age-related movement disorder characterized by the progressive loss of nigrostriatal dopaminergic neurons. To date,…”
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A Novel Class of Tyrosyl-DNA Phosphodiesterase 1 Inhibitors That Contains the Octahydro-2H-chromen-4-ol Scaffold by Li-Zhulanov, Nikolai, Zakharenko, Alexandra, Chepanova, Arina, Patel, Jinal, Zafar, Ayesha, Volcho, Konstantin, Salakhutdinov, Nariman, Reynisson, Jóhannes, Leung, Ivanhoe, Lavrik, Olga

“…Tyrosyl-DNA phosphodiesterase 1 (Tdp1) is a DNA repair enzyme that mends topoisomerase 1-mediated DNA damage. Tdp1 is a current inhibition target for the…”
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Identification and Study of the Action Mechanism of Small Compound That Inhibits Replication of Respiratory Syncytial Virus by Shtro, Anna A, Klabukov, Artem M, Garshinina, Anzhelika V, Galochkina, Anastasia V, Nikolaeva, Yulia V, Khomenko, Tatyana M, Bobkov, Danila E, Lozhkov, Aleksey A, Sivak, Konstantin V, Yakovlev, Kirill S, Komissarov, Andrey B, Borisevich, Sophia S, Volcho, Konstantin P, Salakhutdinov, Nariman F

“…Respiratory syncytial virus (RSV) is known to cause annual epidemics of respiratory infections; however, the lack of specific treatment options for this…”
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