New Antibacterial Chloro-Containing Polyketides from the Alga-Derived Fungus Asteromyces cruciatus KMM 4696

Six new polyketides acrucipentyns A-F ( - ) were isolated from the alga-derived fungus KMM 4696. Their structures were established based on spectroscopic methods. The absolute configurations of acrucipentyn A was assigned by the modified Mosher's method and ROESY data analysis. Acrucipentyns A-...

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Bibliographic Details
Published in:	Journal of fungi (Basel) Vol. 8; no. 5; p. 454
Main Authors:	Zhuravleva, Olesya I, Oleinikova, Galina K, Antonov, Alexandr S, Kirichuk, Natalia N, Pelageev, Dmitry N, Rasin, Anton B, Menshov, Alexander S, Popov, Roman S, Kim, Natalya Yu, Chingizova, Ekaterina A, Chingizov, Artur R, Volchkova, Olga O, von Amsberg, Gunhild, Dyshlovoy, Sergey A, Yurchenko, Ekaterina A, Guzhova, Irina V, Yurchenko, Anton N
Format:	Journal Article
Language:	English
Published:	Switzerland MDPI AG 27-04-2022 MDPI
Subjects:	Algae Antimicrobial agents Asteromyces cruciatus Bacteria Biofilms chlore-containing metabolites Chlorine Chromatography Cytotoxicity Enzymatic activity Enzymes Fungi Gram-positive bacteria Keratinocytes marine fungi Metabolism Metabolites Polyketides secondary metabolites Sortase sortase A Staphylococcus aureus Virulence Sea of Japan United States > US Japan Germany Russia antibacterial activity chlore-containing metabolites secondary metabolites sortase A marine fungi biofilm formation Asteromyces cruciatus polyketides Staphylococcus aureus
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Summary:	Six new polyketides acrucipentyns A-F ( - ) were isolated from the alga-derived fungus KMM 4696. Their structures were established based on spectroscopic methods. The absolute configurations of acrucipentyn A was assigned by the modified Mosher's method and ROESY data analysis. Acrucipentyns A-E were identified to be the very first examples of chlorine-containing asperpentyn-like compounds. The cytotoxic and antimicrobial activities of the isolated compounds were examined. Acrucipentyns A-F were found as antimicrobial agents, which inhibited sortase A enzyme activity, bacterial growth and biofilm formation of and decreased LDH release from human keratinocytes HaCaT in skin infection in an in vitro model.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	2309-608X 2309-608X
DOI:	10.3390/jof8050454