Search Results - "Vojtesek, Borivoj"

STAT3, stem cells, cancer stem cells and p63 by Galoczova, Michaela, Coates, Philip, Vojtesek, Borivoj

“…Signal Transducer and Activator of Transcription 3 (STAT3) is a transcription factor with many important functions in the biology of normal and transformed…”
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The role of the 3' untranslated region in post-transcriptional regulation of protein expression in mammalian cells by Matoulkova, Eva, Michalova, Eva, Vojtesek, Borivoj, Hrstka, Roman

“…The untranslated regions (UTRs) at the 3'end of mRNA transcripts contain important sequences that influence the fate of mRNA and thus proteosynthesis. In this…”
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In Vitro Cross-Linking MS Reveals SMG1-UPF2-SMG7 Assembly as Molecular Partners within the NMD Surveillance by Padariya, Monikaben, Vojtesek, Borivoj, Hupp, Ted, Kalathiya, Umesh

“…mRNAs containing premature stop codons are responsible for various genetic diseases as well as cancers. The truncated proteins synthesized from these aberrant…”
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Suppression of AGR2 in a TGF-β-induced Smad regulatory pathway mediates epithelial-mesenchymal transition by Sommerova, Lucia, Ondrouskova, Eva, Vojtesek, Borivoj, Hrstka, Roman

“…During cancer progression, epithelial cancer cells can be reprogrammed into mesenchymal-like cells with increased migratory potential through the process of…”
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Complex and variable regulation of ΔNp63 and TAp63 by TGFβ has implications for the dynamics of squamous cell epithelial to mesenchymal transition by Pokorná, Zuzana, Tylichová, Zuzana, Vojtesek, Borivoj, Coates, Philip J.

“…TGFβ has roles in inflammation, wound healing, epithelial to mesenchymal transition (EMT), and cancer stem cell states, and acts as a tumor suppressor gene for…”
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Direct activation of HSF1 by macromolecular crowding and misfolded proteins by Simoncik, Oliver, Tichy, Vlastimil, Durech, Michal, Hernychova, Lenka, Trcka, Filip, Uhrik, Lukas, Bardelcik, Miroslav, Coates, Philip J, Vojtesek, Borivoj, Muller, Petr

“…Stress responses play a vital role in cellular survival against environmental challenges, often exploited by cancer cells to proliferate, counteract genomic…”
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TAp63 and ΔNp63 (p40) in prostate adenocarcinomas: ΔNp63 associates with a basal-like cancer stem cell population but not with metastasis by Galoczova, Michaela, Nenutil, Rudolf, Pokorna, Zuzana, Vojtesek, Borivoj, Coates, Philip J.

“…Like other malignancies, prostate tumors are thought to contain cancer stem-like cells (CSCs) that are responsible for growth, metastasis, and therapy…”
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Resistance mechanisms to inhibitors of p53-MDM2 interactions in cancer therapy: can we overcome them? by Haronikova, Lucia, Bonczek, Ondrej, Zatloukalova, Pavlina, Kokas-Zavadil, Filip, Kucerikova, Martina, Coates, Philip J, Fahraeus, Robin, Vojtesek, Borivoj

“…Since the discovery of the first MDM2 inhibitors, we have gained deeper insights into the cellular roles of MDM2 and p53. In this review, we focus on MDM2…”
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DNA and RNA Binding Proteins: From Motifs to Roles in Cancer by Bonczek, Ondrej, Wang, Lixiao, Gnanasundram, Sivakumar Vadivel, Chen, Sa, Haronikova, Lucia, Zavadil-Kokas, Filip, Vojtesek, Borivoj

“…DNA and RNA binding proteins (DRBPs) are a broad class of molecules that regulate numerous cellular processes across all living organisms, creating intricate…”
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N-glycan profiling of tissue samples to aid breast cancer subtyping by Benesova, Iva, Nenutil, Rudolf, Urminsky, Adam, Lattova, Erika, Uhrik, Lukas, Grell, Peter, Kokas, Filip Zavadil, Halamkova, Jana, Zdrahal, Zbynek, Vojtesek, Borivoj, Novotny, Milos V., Hernychova, Lenka

“…Breast cancer is a highly heterogeneous disease. Its intrinsic subtype classification for diagnosis and choice of therapy traditionally relies on the presence…”
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The Role of IFITM Proteins in Tick-Borne Encephalitis Virus Infection by Chmielewska, Alicja M, Gómez-Herranz, Maria, Gach, Paulina, Nekulova, Marta, Bagnucka, Małgorzata A, Lipińska, Andrea D, Rychłowski, Michał, Hoffmann, Weronika, Król, Ewelina, Vojtesek, Borivoj, Sloan, Richard D, Bieńkowska-Szewczyk, Krystyna, Hupp, Ted, Ball, Kathryn

“…Tick-borne encephalitis virus (TBEV), of the genus , is a causative agent of severe encephalitis in regions of endemicity of northern Asia and central and…”
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Os(VI)bipy-based electrochemical assay for detection of specific microRNAs as potential cancer biomarkers by Bartosik, Martin, Trefulka, Mojmir, Hrstka, Roman, Vojtesek, Borivoj, Palecek, Emil

“…Recently, altered expression levels of microRNAs (miRNAs) – short noncoding RNA molecules which bind to mRNAs and thus regulate gene expression – were observed…”
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A global analysis of the complex landscape of isoforms and regulatory networks of p63 in human cells and tissues by Sethi, Isha, Romano, Rose-Anne, Gluck, Christian, Smalley, Kirsten, Vojtesek, Borivoj, Buck, Michael J, Sinha, Satrajit

“…The transcription factor p63 belongs to the p53/p63/p73 family and plays key functional roles during normal epithelial development and differentiation and in…”
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DNA Demethylation Switches Oncogenic ΔNp63 to Tumor Suppressive TAp63 in Squamous Cell Carcinoma by Pokorna, Zuzana, Hrabal, Vaclav, Tichy, Vlastimil, Vojtesek, Borivoj, Coates, Philip J.

“…The TP63 gene encodes two major protein variants; TAp63 contains a p53-like transcription domain and consequently has tumor suppressor activities whereas ΔNp63…”
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Impairment of carbonic anhydrase IX ectodomain cleavage reinforces tumorigenic and metastatic phenotype of cancer cells by Kajanova, Ivana, Zatovicova, Miriam, Jelenska, Lenka, Sedlakova, Olga, Barathova, Monika, Csaderova, Lucia, Debreova, Michaela, Lukacikova, Lubomira, Grossmannova, Katarina, Labudova, Martina, Golias, Tereza, Svastova, Eliska, Ludwig, Andreas, Muller, Petr, Vojtesek, Borivoj, Pastorek, Jaromir, Pastorekova, Silvia

“…Background Carbonic anhydrase IX (CA IX) is a hypoxia-induced enzyme regulating tumour pH and facilitating cell migration/invasion. It is primarily expressed…”
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Identifying pathways regulating the oncogenic p53 family member ΔNp63 provides therapeutic avenues for squamous cell carcinoma by Pokorna, Zuzana, Vyslouzil, Jan, Vojtesek, Borivoj, Coates, Philip J

“…ΔNp63 overexpression is a common event in squamous cell carcinoma (SCC) that contributes to tumorigenesis, making ΔNp63 a potential target for therapy. We…”
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Stat3 Tyrosine 705 and Serine 727 Phosphorylation Associate With Clinicopathological Characteristics and Distinct Tumor Cell Phenotypes in Triple-Negative Breast Cancer by Stenckova, Michaela, Nenutil, Rudolf, Vojtesek, Borivoj, Coates, Philip J.

“…Signal transducer and activator of transcription 3 (Stat3) is responsible for many aspects of normal development and contributes to the development and…”
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N-Glycome changes reflecting resistance to platinum-based chemotherapy in ovarian cancer by Zahradnikova, Martina, Ihnatova, Ivana, Lattova, Erika, Uhrik, Lukas, Stuchlikova, Eliska, Nenutil, Rudolf, Valik, Dalibor, Nalezinska, Monika, Chovanec, Josef, Zdrahal, Zbynek, Vojtesek, Borivoj, Hernychova, Lenka, Novotny, Milos V.

“…A number of studies have reported aberrant glycosylation in connection with malignancy. Our investigation further expands on this topic through the examination…”
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MDM2 inhibitors, nutlin-3a and navtemadelin, retain efficacy in human and mouse cancer cells cultured in hypoxia by Lerma Clavero, Ada, Boqvist, Paula Lafqvist, Ingelshed, Katrine, Bosdotter, Cecilia, Sedimbi, Saikiran, Jiang, Long, Wermeling, Fredrik, Vojtesek, Borivoj, Lane, David P., Kannan, Pavitra

“…Activation of p53 by small molecule MDM2 inhibitors can induce cell cycle arrest or death in p53 wildtype cancer cells. However, cancer cells exposed to…”
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Comparative characterization of two monoclonal antibodies targeting canine PD-1 by Kocikowski, Mikolaj, Dziubek, Katarzyna, Węgrzyn, Katarzyna, Hrabal, Vaclav, Zavadil-Kokas, Filip, Vojtesek, Borivoj, Alfaro, Javier Antonio, Hupp, Ted, Parys, Maciej

“…Monoclonal antibodies targeting immune checkpoints have revolutionized oncology. Yet, the effectiveness of these treatments varies significantly among…”
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