Search Results - "Vogt‐Weisenhorn, Daniela"

β‐catenin signaling modulates the tempo of dendritic growth of adult‐born hippocampal neurons by Heppt, Jana, Wittmann, Marie‐Theres, Schäffner, Iris, Billmann, Charlotte, Zhang, Jingzhong, Vogt‐Weisenhorn, Daniela, Prakash, Nilima, Wurst, Wolfgang, Taketo, Makoto Mark, Lie, Dieter Chichung

“…In adult hippocampal neurogenesis, stem/progenitor cells generate dentate granule neurons that contribute to hippocampal plasticity. The establishment of a…”
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Chapter 5 – “Parkinson's disease – A role of non-enzymatic posttranslational modifications in disease onset and progression?” by Schmidt, Sebastian, Vogt Weisenhorn, Daniela M., Wurst, Wolfgang

“…Parkinson's disease (PD) is a still incurable neurodegenerative disorder with a highly complex etiology. While about 10% of cases are associated with…”
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Parkinson's disease motor symptoms rescue by CRISPRa‐reprogramming astrocytes into GABAergic neurons by Giehrl‐Schwab, Jessica, Giesert, Florian, Rauser, Benedict, Lao, Chu Lan, Hembach, Sina, Lefort, Sandrine, Ibarra, Ignacio L, Koupourtidou, Christina, Luecken, Malte Daniel, Truong, Dong‐Jiunn Jeffery, Fischer‐Sternjak, Judith, Masserdotti, Giacomo, Prakash, Nilima, Ninkovic, Jovica, Hölter, Sabine M, Vogt Weisenhorn, Daniela M, Theis, Fabian J, Götz, Magdalena, Wurst, Wolfgang

“…Direct reprogramming based on genetic factors resembles a promising strategy to replace lost cells in degenerative diseases such as Parkinson's disease. For…”
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A reversible state of hypometabolism in a human cellular model of sporadic Parkinson’s disease by Schmidt, Sebastian, Stautner, Constantin, Vu, Duc Tung, Heinz, Alexander, Regensburger, Martin, Karayel, Ozge, Trümbach, Dietrich, Artati, Anna, Kaltenhäuser, Sabine, Nassef, Mohamed Zakaria, Hembach, Sina, Steinert, Letyfee, Winner, Beate, Jürgen, Winkler, Jastroch, Martin, Luecken, Malte D., Theis, Fabian J., Westmeyer, Gil Gregor, Adamski, Jerzy, Mann, Matthias, Hiller, Karsten, Giesert, Florian, Vogt Weisenhorn, Daniela M., Wurst, Wolfgang

“…Sporadic Parkinson’s Disease (sPD) is a progressive neurodegenerative disorder caused by multiple genetic and environmental factors. Mitochondrial dysfunction…”
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A WNT1-regulated developmental gene cascade prevents dopaminergic neurodegeneration in adult En1+/− mice by Zhang, Jingzhong, Götz, Sebastian, Vogt Weisenhorn, Daniela M, Simeone, Antonio, Wurst, Wolfgang, Prakash, Nilima

“…Abstract The protracted and age-dependent degeneration of dopamine (DA)-producing neurons of the Substantia nigra pars compacta (SNc) and ventral tegmental…”
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Parkinson's disease mutations in PINK1 result in decreased Complex I activity and deficient synaptic function by Morais, Vanessa A., Verstreken, Patrik, Roethig, Anne, Smet, Joél, Snellinx, An, Vanbrabant, Mieke, Haddad, Dominik, Frezza, Christian, Mandemakers, Wim, Vogt‐Weisenhorn, Daniela, Van Coster, Rudy, Wurst, Wolfgang, Scorrano, Luca, De Strooper, Bart

“…Mutations of the mitochondrial PTEN (phosphatase and tensin homologue)‐induced kinase1 (PINK1) are important causes of recessive Parkinson disease (PD)…”
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PARK7/DJ-1 deficiency impairs microglial activation in response to LPS-induced inflammation by Lind-Holm Mogensen, Frida, Sousa, Carole, Ameli, Corrado, Badanjak, Katja, Pereira, Sandro L, Muller, Arnaud, Kaoma, Tony, Coowar, Djalil, Scafidi, Andrea, Poovathingal, Suresh K, Tziortziou, Maria, Antony, Paul M A, Nicot, Nathalie, Ginolhac, Aurélien, Vogt Weisenhorn, Daniela M, Wurst, Wolfgang, Poli, Aurélie, Nazarov, Petr V, Skupin, Alexander, Grünewald, Anne, Michelucci, Alessandro

“…Specific microglia responses are thought to contribute to the development and progression of neurodegenerative diseases, including Parkinson's disease (PD)…”
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The Parkinson’s disease-linked Leucine-rich repeat kinase 2 (LRRK2) is required for insulin-stimulated translocation of GLUT4 by Funk, Natalja, Munz, Marita, Ott, Thomas, Brockmann, Kathrin, Wenninger-Weinzierl, Andrea, Kühn, Ralf, Vogt-Weisenhorn, Daniela, Giesert, Florian, Wurst, Wolfgang, Gasser, Thomas, Biskup, Saskia

“…Mutations within Leucine-rich repeat kinase 2 (LRRK2) are associated with late-onset Parkinson’s disease. The physiological function of LRRK2 and molecular…”
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FGF/FGFR2 signaling regulates the generation and correct positioning of Bergmann glia cells in the developing mouse cerebellum by Meier, Florian, Giesert, Florian, Delic, Sabit, Faus-Kessler, Theresa, Matheus, Friederike, Simeone, Antonio, Hölter, Sabine M, Kühn, Ralf, Weisenhorn, Daniela M Vogt, Wurst, Wolfgang, Prakash, Nilima

“…The normal cellular organization and layering of the vertebrate cerebellum is established during embryonic and early postnatal development by the interplay of…”
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LRRK2 controls synaptic vesicle storage and mobilization within the recycling pool by Piccoli, Giovanni, Condliffe, Steven B, Bauer, Matthias, Giesert, Florian, Boldt, Karsten, De Astis, Silvia, Meixner, Andrea, Sarioglu, Hakan, Vogt-Weisenhorn, Daniela M, Wurst, Wolfgang, Gloeckner, Christian Johannes, Matteoli, Michela, Sala, Carlo, Ueffing, Marius

“…Mutations in leucine-rich repeat kinase 2 (LRRK2) are the single most common cause of inherited Parkinson's disease. Little is known about its involvement in…”
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Primary cilia and SHH signaling impairments in human and mouse models of Parkinson’s disease by Schmidt, Sebastian, Luecken, Malte D., Trümbach, Dietrich, Hembach, Sina, Niedermeier, Kristina M., Wenck, Nicole, Pflügler, Klaus, Stautner, Constantin, Böttcher, Anika, Lickert, Heiko, Ramirez-Suastegui, Ciro, Ahmad, Ruhel, Ziller, Michael J., Fitzgerald, Julia C., Ruf, Viktoria, van de Berg, Wilma D. J., Jonker, Allert J., Gasser, Thomas, Winner, Beate, Winkler, Jürgen, Vogt Weisenhorn, Daniela M., Giesert, Florian, Theis, Fabian J., Wurst, Wolfgang

“…Parkinson’s disease (PD) as a progressive neurodegenerative disorder arises from multiple genetic and environmental factors. However, underlying pathological…”
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Epigenome-wide DNA methylation profiling in Progressive Supranuclear Palsy reveals major changes at DLX1 by Weber, Axel, Schwarz, Sigrid C., Tost, Jörg, Trümbach, Dietrich, Winter, Pia, Busato, Florence, Tacik, Pawel, Windhorst, Anita C., Fagny, Maud, Arzberger, Thomas, McLean, Catriona, van Swieten, John C., Schwarz, Johannes, Vogt Weisenhorn, Daniela, Wurst, Wolfgang, Adhikary, Till, Dickson, Dennis W., Höglinger, Günter U., Müller, Ulrich

“…Genetic, epigenetic, and environmental factors contribute to the multifactorial disorder progressive supranuclear palsy (PSP). Here, we study epigenetic…”
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Pink1-deficiency in mice impairs gait, olfaction and serotonergic innervation of the olfactory bulb by Glasl, Lisa, Kloos, Karina, Giesert, Florian, Roethig, Anne, Di Benedetto, Barbara, Kühn, Ralf, Zhang, Jingzhong, Hafen, Ulrich, Zerle, Julia, Hofmann, Andreas, Hrabé de Angelis, Martin, Winklhofer, Konstanze F., Hölter, Sabine M., Vogt Weisenhorn, Daniela M., Wurst, Wolfgang

“…Parkinson's Disease (PD) is the most common neurodegenerative movement disorder. Autosomal-recessive mutations in the mitochondrial protein kinase PINK1…”
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A Wnt1-regulated genetic network controls the identity and fate of midbrain-dopaminergic progenitors in vivo by Prakash, Nilima, Brodski, Claude, Naserke, Thorsten, Puelles, Eduardo, Gogoi, Robindra, Hall, Anita, Panhuysen, Markus, Echevarria, Diego, Sussel, Lori, Weisenhorn, Daniela M Vogt, Martinez, Salvador, Arenas, Ernest, Simeone, Antonio, Wurst, Wolfgang

“…Midbrain neurons synthesizing the neurotransmitter dopamine play a central role in the modulation of different brain functions and are associated with major…”
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A powerful transgenic tool for fate mapping and functional analysis of newly generated neurons by Zhang, Jingzhong, Giesert, Florian, Kloos, Karina, Vogt Weisenhorn, Daniela M, Aigner, Ludwig, Wurst, Wolfgang, Couillard-Despres, Sebastien

“…Lack of appropriate tools and techniques to study fate and functional integration of newly generated neurons has so far hindered understanding of neurogenesis'…”
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Expression analysis of Lrrk1, Lrrk2 and Lrrk2 splice variants in mice by Giesert, Florian, Hofmann, Andreas, Bürger, Alexander, Zerle, Julia, Kloos, Karina, Hafen, Ulrich, Ernst, Luise, Zhang, Jingzhong, Vogt-Weisenhorn, Daniela Maria, Wurst, Wolfgang

“…Missense mutations in the leucine-rich repeat kinase 2 gene (LRRK2) are linked to autosomal dominant forms of Parkinson's disease (PD). In order to get…”
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Human Dopaminergic Neurons Lacking PINK1 Exhibit Disrupted Dopamine Metabolism Related to Vitamin B6 Co-Factors by Bus, Christine, Zizmare, Laimdota, Feldkaemper, Marita, Geisler, Sven, Zarani, Maria, Schaedler, Anna, Klose, Franziska, Admard, Jakob, Mageean, Craig J., Arena, Giuseppe, Fallier-Becker, Petra, Ugun-Klusek, Aslihan, Maruszczak, Klaudia K., Kapolou, Konstantina, Schmid, Benjamin, Rapaport, Doron, Ueffing, Marius, Casadei, Nicolas, Krüger, Rejko, Gasser, Thomas, Vogt Weisenhorn, Daniela M., Kahle, Philipp J., Trautwein, Christoph, Gloeckner, Christian J., Fitzgerald, Julia C.

“…PINK1 loss-of-function mutations cause early onset Parkinson disease. PINK1-Parkin mediated mitophagy has been well studied, but the relevance of the…”
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A brain-enriched circular RNA controls excitatory neurotransmission and restricts sensitivity to aversive stimuli by Giusti, Sebastian A, Pino, Natalia S, Pannunzio, Camila, Ogando, Mora B, Armando, Natalia G, Garrett, Lillian, Zimprich, Annemarie, Becker, Lore, Gimeno, Maria L, Lukin, Jeronimo, Merino, Florencia L, Pardi, M Belen, Pedroncini, Olivia, Di Mauro, Giuliana C, Durner, Valerie Gailus, Fuchs, Helmut, de Angelis, Martin Hrabe, Patop, Ines L, Turck, Christoph W, Deussing, Jan M, Vogt Weisenhorn, Daniela M, Jahn, Olaf, Kadener, Sebastian, Hölter, Sabine M, Brose, Nils, Giesert, Florian, Wurst, Wolfgang, Marin-Burgin, Antonia, Refojo, Damian

“…Circular RNAs (circRNAs) are a large class of noncoding RNAs. Despite the identification of thousands of circular transcripts, the biological significance of…”
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Location and Size of Dopaminergic and Serotonergic Cell Populations Are Controlled by the Position of the Midbrain-Hindbrain Organizer by Brodski, Claude, Weisenhorn, Daniela M. Vogt, Signore, Massimo, Sillaber, Inge, Oesterheld, Matthias, Broccoli, Vania, Acampora, Dario, Simeone, Antonio, Wurst, Wolfgang

“…Midbrain dopaminergic and hindbrain serotonergic neurons play an important role in the modulation of behavior and are involved in a series of neuropsychiatric…”
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Fibroblast Growth Factor Receptors Cooperate to Regulate Neural Progenitor Properties in the Developing Midbrain and Hindbrain by Saarimaki-Vire, Jonna, Peltopuro, Paula, Lahti, Laura, Naserke, Thorsten, Blak, Alexandra A, Vogt Weisenhorn, Daniela M, Yu, Kai, Ornitz, David M, Wurst, Wolfgang, Partanen, Juha

“…Fibroblast growth factors (FGFs) secreted from the midbrain-rhombomere 1 (r1) boundary instruct cell behavior in the surrounding neuroectoderm. For example, a…”
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