Search Results - "Vogelstein, Bert"

The Path to Cancer — Three Strikes and You're Out by Vogelstein, Bert, Kinzler, Kenneth W

“…Focusing on driver-gene mutations and the pathways they control has rendered complex cancer-genome landscapes intelligible. In solid tumors of adults,…”
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Stem cell divisions, somatic mutations, cancer etiology, and cancer prevention by Tomasetti, Cristian, Li, Lu, Vogelstein, Bert

“…Cancers are caused by mutations that may be inherited, induced by environmental factors, or result from DNA replication errors (R). We studied the relationship…”
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Half or more of the somatic mutations in cancers of self-renewing tissues originate prior to tumor initiation by Tomasetti, Cristian, Vogelstein, Bert, Parmigiani, Giovanni

“…Although it has been hypothesized that some of the somatic mutations found in tumors may occur before tumor initiation, there is little experimental or…”
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Only three driver gene mutations are required for the development of lung and colorectal cancers by Tomasett, Cristiani, Marchionni, Luigi, Nowak, Martin A., Parmigiani, Giovanni, Vogelstein, Bert

“…Significance The number of driver events required for human tumorigenesis has remained one of the fundamental issues in cancer research since the seminal…”
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Detection and quantification of rare mutations with massively parallel sequencing by Kinde, Isaac, Wu, Jian, Papadopoulos, Nick, Kinzler, Kenneth W, Vogelstein, Bert

“…The identification of mutations that are present in a small fraction of DNA templates is essential for progress in several areas of biomedical research…”
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Minimal functional driver gene heterogeneity among untreated metastases by Reiter, Johannes G, Makohon-Moore, Alvin P, Gerold, Jeffrey M, Heyde, Alexander, Attiyeh, Marc A, Kohutek, Zachary A, Tokheim, Collin J, Brown, Alexia, DeBlasio, Rayne M, Niyazov, Juliana, Zucker, Amanda, Karchin, Rachel, Kinzler, Kenneth W, Iacobuzio-Donahue, Christine A, Vogelstein, Bert, Nowak, Martin A

“…Metastases are responsible for the majority of cancer-related deaths. Although genomic heterogeneity within primary tumors is associated with relapse,…”
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Evaluating the evaluation of cancer driver genes by Tokheim, Collin J., Papadopoulos, Nickolas, Kinzler, Kenneth W., Vogelstein, Bert, Karchin, Rachel

“…Sequencing has identified millions of somatic mutations in human cancers, but distinguishing cancer driver genes remains a major challenge. Numerous methods…”
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Circulating tumor DNA dynamics and recurrence risk in patients undergoing curative intent resection of colorectal cancer liver metastases: A prospective cohort study by Tie, Jeanne, Wang, Yuxuan, Cohen, Joshua, Li, Lu, Hong, Wei, Christie, Michael, Wong, Hui Li, Kosmider, Suzanne, Wong, Rachel, Thomson, Benjamin, Choi, Julian, Fox, Adrian, Field, Kathryn, Burge, Matthew, Shannon, Jenny, Kotasek, Dusan, Tebbutt, Niall C, Karapetis, Christos, Underhill, Craig, Haydon, Andrew, Schaeffer, Joy, Ptak, Janine, Tomasetti, Cristian, Papadopoulos, Nicholas, Kinzler, Kenneth W, Vogelstein, Bert, Gibbs, Peter

“…In patients with resectable colorectal liver metastases (CRLM), the role of pre- and postoperative systemic therapy continues to be debated. Previous studies…”
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Mutation of the TERT promoter, switch to active chromatin, and monoallelic TERT expression in multiple cancers by Stern, Josh Lewis, Theodorescu, Dan, Vogelstein, Bert, Papadopoulos, Nickolas, Cech, Thomas R

“…Somatic mutations in the promoter of the gene for telomerase reverse transcriptase (TERT) are the most common noncoding mutations in cancer. They are thought…”
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Cancer Genome Landscapes by Vogelstein, Bert, Papadopoulos, Nickolas, Velculescu, Victor E., Zhou, Shibin, Diaz, Luis A., Kinzler, Kenneth W.

“…Over the past decade, comprehensive sequencing efforts have revealed the genomic landscapes of common forms of human cancer. For most cancer types, this…”
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Circulating Tumor DNA Analysis Guiding Adjuvant Therapy in Stage II Colon Cancer by Tie, Jeanne, Cohen, Joshua D., Lahouel, Kamel, Lo, Serigne N., Wang, Yuxuan, Kosmider, Suzanne, Wong, Rachel, Shapiro, Jeremy, Lee, Margaret, Harris, Sam, Khattak, Adnan, Burge, Matthew, Harris, Marion, Lynam, James, Nott, Louise, Day, Fiona, Hayes, Theresa, McLachlan, Sue-Anne, Lee, Belinda, Ptak, Janine, Silliman, Natalie, Dobbyn, Lisa, Popoli, Maria, Hruban, Ralph, Lennon, Anne Marie, Papadopoulos, Nicholas, Kinzler, Kenneth W., Vogelstein, Bert, Tomasetti, Cristian, Gibbs, Peter

“…In a randomized, controlled trial, a ctDNA-guided approach to the postsurgical treatment of stage II colon cancer reduced adjuvant chemotherapy use without…”
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Disruption of a self-amplifying catecholamine loop reduces cytokine release syndrome by Staedtke, Verena, Bai, Ren-Yuan, Kim, Kibem, Darvas, Martin, Davila, Marco L., Riggins, Gregory J., Rothman, Paul B., Papadopoulos, Nickolas, Kinzler, Kenneth W., Vogelstein, Bert, Zhou, Shibin

“…Cytokine release syndrome (CRS) is a life-threatening complication of several new immunotherapies used to treat cancers and autoimmune diseases 1 – 5 . Here we…”
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Evolutionary dynamics of cancer in response to targeted combination therapy by Bozic, Ivana, Reiter, Johannes G, Allen, Benjamin, Antal, Tibor, Chatterjee, Krishnendu, Shah, Preya, Moon, Yo Sup, Yaqubie, Amin, Kelly, Nicole, Le, Dung T, Lipson, Evan J, Chapman, Paul B, Diaz, Jr, Luis A, Vogelstein, Bert, Nowak, Martin A

“…In solid tumors, targeted treatments can lead to dramatic regressions, but responses are often short-lived because resistant cancer cells arise. The major…”
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Cancer prevention: Molecular and epidemiologic consensus by Song, Mingyang, Vogelstein, Bert, Giovannucci, Edward L, Willett, Walter C, Tomasetti, Cristian

“…Research in many fields emphasizes the value of prevention Prevention of any disease can occur at two levels: (i) avoiding or reducing risk factors coupled…”
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An analysis of genetic heterogeneity in untreated cancers by Reiter, Johannes G., Baretti, Marina, Gerold, Jeffrey M., Makohon-Moore, Alvin P., Daud, Adil, Iacobuzio-Donahue, Christine A., Azad, Nilofer S., Kinzler, Kenneth W., Nowak, Martin A., Vogelstein, Bert

“…Genetic intratumoural heterogeneity is a natural consequence of imperfect DNA replication. Any two randomly selected cells, whether normal or cancerous, are…”
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Eradication of metastatic mouse cancers resistant to immune checkpoint blockade by suppression of myeloid-derived cells by Kim, KiBem, Skora, Andrew D., Li, Zhaobo, Liu, Qiang, Tam, Ada J., Blosser, Richard L., Diaz, Luis A., Papadopoulos, Nickolas, Kinzler, Kenneth W., Vogelstein, Bert, Zhou, Shibin

“…Impressive responses have been observed in patients treated with checkpoint inhibitory anti–programmed cell death-1 (PD-1) or anti–cytotoxic…”
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On the slope of the regression between stem cell divisions and cancer risk, and the lack of correlation between stem cell divisions and environmental factors-associated cancer risk by Tomasetti, Cristian, Vogelstein, Bert

“…Little et al. [1] misrepresent our findings [2] by making incorrect statements that are similar to those previously found in some media. The problem with these…”
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Presence of Somatic Mutations in Most Early-Stage Pancreatic Intraepithelial Neoplasia by Kanda, Mitsuro, Matthaei, Hanno, Wu, Jian, Hong, Seung–Mo, Yu, Jun, Borges, Michael, Hruban, Ralph H, Maitra, Anirban, Kinzler, Kenneth, Vogelstein, Bert, Goggins, Michael

“…More information is needed about genetic factors that initiate development of pancreatic intraepithelial neoplasms—the most common precursors of pancreatic…”
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The molecular evolution of acquired resistance to targeted EGFR blockade in colorectal cancers by Diaz Jr, Luis A., Williams, Richard T., Wu, Jian, Kinde, Isaac, Hecht, J. Randolph, Berlin, Jordan, Allen, Benjamin, Bozic, Ivana, Reiter, Johannes G., Nowak, Martin A., Kinzler, Kenneth W., Oliner, Kelly S., Vogelstein, Bert

“…This work on colorectal cancer shows that secondary mutations in KRAS that confer resistance to panitumumab, an anti-EGFR monoclonal antibody, are already…”
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Genome-wide quantification of rare somatic mutations in normal human tissues using massively parallel sequencing by Hoang, Margaret L., Kinde, Isaac, Tomasetti, Cristian, McMahon, K. Wyatt, Rosenquist, Thomas A., Grollman, Arthur P., Kinzler, Kenneth W., Vogelstein, Bert, Papadopoulos, Nickolas

“…We present the bottleneck sequencing system (BotSeqS), a next-generation sequencing method that simultaneously quantifies rare somatic point mutations across…”
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